DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and glr-7

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_001337310.1	Gene:	glr-7 / 180547	WormBaseID:	WBGene00001618	Length:	885	Species:	Caenorhabditis elegans

Alignment Length:	927	Identity:	219/927 - (23%)
Similarity:	397/927 - (42%)	Gaps:	183/927 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 DNYQSLESVPIGLLTDQNTEQMNIVFDHAIDVANQEVG--------TSLTSLKEEVNYGDAYQSY 87
            :.|...:|..|..|.||   .:|:.|..::..:|..:.        :.:.:::.::||.....::
Worm    15 ERYDFNDSSDINSLCDQ---MVNVSFVISVCRSNDSISLVAELARISQVPTIQVDLNYWSLPLNF 76

  Fly    88 GKLCRMLETGIAGVFGPSSRHTAVHLMSICDAMDIPHIYSYMSENAEGFNLHPHPADLAKALYSL 152
            .      .|.:..:..||  :|.:.|.::.....|..|::       ..|:.|:...|...:|.
Worm    77 N------GTSVPTISSPS--YTTMVLSTLVFQNVITDIFA-------DLNITPNSTVLYDNMYP- 125

  Fly   153 ITEFNWTRFIFLYESAEYLNILNELTTMLGKSGTVITVLRYDMQLNGNYKQVLRRVRKSVDNRIV 217
             .:|...|..|        ::|..:..:..::    ||||...|:.        ::|.:..|.::
Worm   126 -PDFTAWRDAF--------SVLPGIRFVPMET----TVLRMRAQIT--------QLRMASINSLI 169

  Fly   218 VVGSSETMPEFLNQAQQVGIINEDYKYIIGNLDFHSFDLEEYKYSEANITGLRLFSPEK-MAVKE 281
            :|..:|.:..|..:|... |....:...:...|..:|..:..:  .|.:..||.|...| |.:::
Worm   170 LVAKTENVERFTLEAADF-IEQRVFNTYVLTKDITAFKCDSCE--SAFMFWLRPFPVGKLMEIRD 231

  Fly   282 LLMKLGYPTDQDEFRNGSCPITVEMALT-----------YDAVQLFA-QTLK--NLPFKPMPQNC 332
            |        |...|||   .|.:|:..:           |..|..:| :|::  |..|..:|...
Worm   232 L--------DDYLFRN---EIGLELDYSINGWDSLNVAFYMNVMGYAFETIRTMNATFDVLPTFT 285

  Fly   333 SQRTESVRDDGSSFKNYMRTLRLTDRLLTGPIYFEGN-VRKGYHLDVIELQPSGIVKVGTWDEDR 396
            .|       .|.|..|...|:|  |.:|..|.:..|| ...|.::...:::    |::...|.||
Worm   286 CQ-------TGPSEPNITTTVR--DIILNDPAHEYGNYTEAGLNMFFQDVE----VRIYKIDRDR 337

  Fly   397 QYRP----------QRLAPTTAQFDSVDNSLANKTFIILLSVPNKPYAQLVETYKQLEGNSQYEG 451
            .:..          ..::..:..:.::...:.|.....::::...|:.|     :..:.::.|||
Worm   338 DHEDALFNKEVGVWSPISKLSVMYGTLQVDVRNLNIFRVVTLIQPPFVQ-----RTGDPDTPYEG 397

  Fly   452 YGVDLIKELADKLGFNFTF--VNGG-----NDYGSYNKSTNESTGMLREIMTGRADLAITDLTIT 509
            |.:|||..:..::.|.:|.  |..|     :|.|::|       |::..:::|.||:|:..|::.
Worm   398 YCIDLINMIQVEVNFTYTIYEVEDGSFGTMDDNGNWN-------GLIGALVSGSADIALAPLSVM 455

  Fly   510 SEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLGFSFLGVSLSFFILGRLS 574
            :|||..:|||:|:.:|....:.:|.......||.||......||..:..::|..|:..:|..|.|
Worm   456 AERENDVDFTVPYYDLVGTTILMKKADVEYSLFKFMKVLEWPVWLCIVAAYLFTSILLWIFDRFS 520

  Fly   575 PSEWDNPYPCIEEPEELEN-----QFTLGNSIWFTTGALLQQGSEIGPKALSTRTVASFWWFFTL 634
            |..:.|      ..|..:|     ||:|...:||...:|..||....||.:|.|.||:.||.|..
Worm   521 PYSFTN------NKERYQNDIEKRQFSLKECLWFCMTSLTPQGGGEAPKNISGRLVAATWWLFGF 579

  Fly   635 IVVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVYGAKKTGSTRNFF--MTSAEERYKKMNK 697
            |:::|||||||||||:.:.:..|:|:|||| .:..:.|...|..::..:|  |...||.:..|.|
Worm   580 IIIASYTANLAAFLTVSRLEQPISSLDDLA-KQYKIEYAPIKGSASETYFRRMAEIEETFYNMWK 643

  Fly   698 FMSENP-------------------------QYLTED----NME-GVNRVKTNTH-YAFLMESTS 731
            .||.|.                         :|:.|.    ||: .|:||..:.. :||:.::|.
Worm   644 EMSLNESMSPRDRAKLAVWDYPVSDKFTNMWRYMQESKLPVNMDTAVDRVLNSVDGFAFIGDATE 708

  Fly   732 IEYNTKRECNLKKIGDALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWW----NEV 792
            |:|.....|||:::|.....|.|.||::.....:.|.::|:|.|..:..||.:|.|||    |:|
Worm   709 IKYAALTNCNLQQVGTEFSRKPYAIAVQSGHILKDKISSAILMLLNERRLETLKEKWWTDNPNKV 773

  Fly   793 GTGICATKEDAPDATPLDMNNLEGVFFVLLVGSCCALLYGIISWVLFVMKKAHHYRVPLRDALKE 857
            .   |....|..|.  :.:.|:.|||.|:|.        ||...::.:..:.::|:...|.|.::
Worm   774 S---CPDSSDESDG--ISIQNIGGVFIVILA--------GIALSIVTLAFEYYYYKRKARKAAEK 825

  Fly   858 EFQFVIDFNNYVRVLKN 874
            | |..::.....:|:.|
Worm   826 E-QEELEMKQSQQVVPN 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	71/377 (19%)
		ANF_receptor	51..382	CDD:279440	66/354 (19%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	123/419 (29%)
		Lig_chan	551..824	CDD:278489	98/314 (31%)
glr-7	NP_001337310.1	Periplasmic_Binding_Protein_Type_1	<102..>220	CDD:324556	26/149 (17%)
glr-7	NP_001337310.1	PBP2_iGluR_putative	373..767	CDD:270435	121/412 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810