Protein Alignment GluRIIE and glr-1

DIOPT Version :10

• Sequence 1: NP_001036733.1
• Gene: GluRIIE / 318623
• FlyBaseID: FBgn0051201
• Length: 897
• Species: Drosophila melanogaster
• Sequence 2: NP_498887.2
• Gene: glr-1 / 176204
• WormBaseID: WBGene00001612
• Length: 962
• Species: Caenorhabditis elegans
• Alignment Length: 977
• Identity: 263/977 - (26%)
• Similarity: 458/977 - (46%)
• Gaps: 146/977 - (14%)

  Fly     2 FFNHFVILWSLFSIHISVNWAQYENFGGYDNYQSLESVPIGLLTDQNTEQMN--------IVFDH 58
            |.|.|.:|:::|::.:...:..:.....:.|.:.:..|.:..: :..::.:|        :.|||
 Worm     7 FLNMFGVLFTVFNLTVVQPYPSHIIIKSFGNNEEVSRVALKAM-EYTSDHINSRDDVPFKLAFDH 70

  Fly    59 AIDVANQEVGTSLTSLKEEVNYGDAYQSYGKLCRMLETGIAGVFGPSSRHTAVHLMSICDAMDIP 123
            .:    .|.|.::           ::.....:|..|:.|...:...........:..:.||:::|
 Worm    71 RV----VEEGAAV-----------SWNMVNAVCDELKEGAMALLSSVDGKGREGIRGVSDALEMP 120

  Fly   124 HIYSYMSENAEG--------FNLHPHPADLAKALYSLITEFNWTRFIFL----YESAEYLNILNE 176
            .:......|.:.        |.:...| .:::.|...|....|...:.|    :.|....::...
 Worm   121 LVSLTALSNDDHQQQQFGNLFEVSVRP-PISELLADFIVHKGWGEVLVLIDPVHASLHLPSLWRH 184

  Fly   177 LTTMLGKSGTVITVLRYDMQLNGN----YKQVLRRVRKSVDNRIVV-VGSSETMPEFLNQAQQVG 236
            |.|   ::.|.:....:|:..:..    |......:|.:..|||:: ..|.:.:.:.|...:...
 Worm   185 LRT---RTNTSVKASMFDLPADEKQFEAYLMQFNMMRNNETNRILIDCASPKRLKKLLINIRSAQ 246

  Fly   237 IINEDYKYIIGNLDFHSFDLEEYKYSEANITGLRLFSP---EKMAVKELL---MKLGYPTDQDEF 295
            ....:|.|::.|.||..:|.|.::....||:|..:.:.   |..::|:.|   ..||
 Worm   247 FNQANYHYVLANYDFLPYDQEMFQNGNINISGFNIINKDGREYWSLKKHLKTSSSLG-------- 303

  Fly   296 RNGSCPITVEMALTYDAV---------------QLFAQTLKNLPF---------------KPMPQ 330
              |...::||.|:.:||:               .||..|.::..|               :..|.
 Worm   304 --GGDDVSVEAAVGHDAMLVTWHGFAKCLQANDSLFHGTFRHRRFFNRGFPGIYCDPLSDRSHPN 366

  Fly   331 NCSQRTESVRDDGSSFKNYMRTLRLTDRLLTGPIYFE--GNVRKGYHLDVIELQPS-----GIVK 388
            ......|..:..|.:|:|  ..:...:..|||.|.|:  || ||.:.:.:::|..:     ...:
 Worm   367 RPFSSFEHGKTIGVAFRN--MKIGHKEGTLTGNIEFDRFGN-RKNFDVSIVDLVSNTKATFNSKE 428

  Fly   389 VGTWDEDRQYRPQRLAPTTAQF------DSVDNSLANKTFIILLSVPNKPYAQLVETYKQLEGNS 447
            |..|.:...:...|   |.||.      |..||.:...|.::...|..|.....:....:.:||:
 Worm   429 VLAWRQGVGFFSNR---TVAQHSRKSQNDHKDNQVIVLTNLVAPFVMIKRECLEMANLTECQGNN 490

  Fly   448 QYEGYGVDLIKELADKL-GFNFTFVNGGNDYGSYNKSTNESTGMLREIMTGRADLAITDLTITSE 511
            ::||:.:||:|.||||: .||:. :..|...|| .::.....||:.|:::|||...:..|||..|
 Worm   491 KFEGFCIDLLKLLADKIEEFNYE-IKLGTKAGS-KQADGSWDGMIGELLSGRAHAVVASLTINQE 553

  Fly   512 REQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLGFSFLGVSLSFFILGRLSPS 576
            ||:.:||:.|||..||:|:..||.|....:|:||.|.|.|:|.::.|:::|||:..|::.|.||.
 Worm   554 RERVVDFSKPFMTTGISIMIKKPDKQEFSVFSFMQPLSTEIWMYIIFAYIGVSVVIFLVSRFSPY 618

  Fly   577 EWDNPYPCIEEPEE----LENQFTLGNSIWFTTGALLQQGSEIGPKALSTRTVASFWWFFTLIVV 637
            ||.     :||...    :.|.|::.|.:|||..|.:|||::|.|:::|.|..:|.|||||:|:|
 Worm   619 EWR-----VEETSRGGFTISNDFSVYNCLWFTLAAFMQQGTDILPRSISGRIASSAWWFFTMIIV 678

  Fly   638 SSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVYGAKKTGSTRNFFMTSAEERYKKMNKFM-SE 701
            ||||||||||||:||.|:.|.||:||| .:..:.||.:..|||.:||..|:.:.|::|.::| |:
 Worm   679 SSYTANLAAFLTLEKMQAPIESVEDLA-KQSKIKYGIQGGGSTASFFKYSSVQIYQRMWRYMESQ 742

  Fly   702 NPQYLTEDNMEGVNRVKTNT-HYAFLMESTSIEY-NTKRECNLKKIGDALDEKGYGIA--MRKDW 762
            .|........||:.||:::. .||||:|:|:.|| ||::.|:..|:|..|:..|||||  ...||
 Worm   743 VPPVFVASYAEGIERVRSHKGRYAFLLEATANEYENTRKPCDTMKVGANLNSIGYGIATPFGSDW 807

  Fly   763 PHRGKFNNALLELQEQGVLEKMKNKWWNEVGTGICATKEDAPDATPLDMNNLEGVFFVLLVGSCC 827
              :...|.|:|.|||:|.|:|::||||.:.|........|...|: |:::.:.|:|::|:.|...
 Worm   808 --KDHINLAILALQERGELKKLENKWWYDRGQCDAGITVDGSSAS-LNLSKVAGIFYILMGGMVI 869

  Fly   828 ALLYGIISWVLFVMKKAHHYRVPLRDALKEEFQFVIDFNNYVRVLKNSASIYSRSRQSSMSVASV 892
            ::|..:..::         ||..:..........|.:|      .||..|..|...:.|:...:|
 Worm   870 SMLAALGEFL---------YRSRIEARKSNSNSMVANF------AKNLKSALSSQLRLSVEGGAV 919

  Fly   893 AQ 894
            ||
 Worm   920 AQ 921

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	40..402	CDD:380605	73/429 (17%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	154/380 (41%)
		Lig_chan	551..824	CDD:459656	115/281 (41%)
glr-1	NP_498887.2	PBP1_iGluR_AMPA	32..442	CDD:380603	75/442 (17%)
		Periplasmic_Binding_Protein_Type_2	457..832	CDD:473866	155/384 (40%)