Protein Alignment GluRIIE and glr-4

DIOPT Version :10

• Sequence 1: NP_001036733.1
• Gene: GluRIIE / 318623
• FlyBaseID: FBgn0051201
• Length: 897
• Species: Drosophila melanogaster
• Sequence 2: NP_001254126.1
• Gene: glr-4 / 174258
• WormBaseID: WBGene00001615
• Length: 951
• Species: Caenorhabditis elegans
• Alignment Length: 937
• Identity: 275/937 - (29%)
• Similarity: 445/937 - (47%)
• Gaps: 126/937 - (13%)

  Fly     6 FVILWSLFSIHISVNWAQYENFGGYDNYQSLESVPIGLLTDQNTEQMNIVFDH---AIDVANQEV 67
            |.||..:|.|   .|.|..:.|            .||.:.::.    :..::|   |||..|.|.
 Worm    11 FSILLVIFYI---ANSAADDRF------------HIGTIANRG----SFAYEHLRYAIDRWNTEH 56

  Fly    68 GTSLT---SLKEEVNYGDAYQSYGKLCRMLETGIAGVF--GPSSRHTAVHLMSICDAMDIPHI-- 125
            |....   |:...:.|.:.|:.  ::|.:::.||..|.  ...|...:..:.|:|...:||.:
 Worm    57 GAHTQIKFSIVSPIRYDNNYEE--RMCEIMQQGIVAVVLSNEESEQDSQLIKSMCHYFNIPCLSL 119

  Fly   126 -YSYMSENAEGF--NLHPHPADLAKALYSLITEFNWTRFIFLYE---SAEYLNILNELTTMLGKS 184
             .:.:.::...|  .|.|.....|:|....:....||.|:..|:   ..|.|:.|.:...::...
 Worm   120 QSTSLRDSVSDFVTLLGPSRGAGARATSEFLDSMRWTGFLLAYQHGSDLEDLSPLMQYKQIVDTG 184

  Fly   185 GTVITV-LRYDMQLNGNYKQVLRRVRKSVDNRIVVVGSSE--TMPEFLNQAQQVGIINEDYKYII 246
            |..|.: :|.......:|:..|:.|:..:....:::.|:.  .:...|.||:.:.:....:.|:.
 Worm   185 GRRIHIKIRRLPNNTDDYEPFLKYVKTRLKQTNIIIHSNNITVLYNLLQQARGLNMAEPPFSYVF 249

  Fly   247 GNLDFHSFDLEEYKYS------EANITGLRLFSPEKMAVKELLMKLGYPTDQDEFRNGSCPITVE 305
            .|.|...  ||::..:      ..|||||:|...:.|      ||                  .:
 Worm   250 TNTDLSL--LEDFLNNMYGASFHCNITGLQLVKNDPM------MK------------------TQ 288

  Fly   306 MALTYDAVQLFAQT---LKNLPFKPMPQNCSQRTESVRDDGSSFKNYMRTLRLTDRLLTGPIYFE 367
            :|||.:||.:...:   ::.|...|...:....:..:..||......:|.|:|.:: |||.:.|:
 Worm   289 LALTSEAVYVVGMSIYRMRELGHAPRQSSIMCDSHDIWSDGRIMNEGIRKLKLRNQ-LTGDVQFK 352

  Fly   368 GNVRKG---YHLDVIELQPSGIVKVGTWDEDRQYRPQRLAPTTAQF----DSVDNSLANKTFIIL 425
            .|..:.   || .|..:. |..||:|.|.|.|.:..........:|    ||.|....:...::.
 Worm   353 SNGERDDIMYH-GVGRIN-SQFVKLGNWSEKRGWNFDSRYANRWEFDIDPDSEDLEGLHLRVVVY 415

  Fly   426 LSVPNKPYAQLVETYKQLEGNSQYEGYGVDLIKELADKLGFNFTFVN-GGNDYGSYNKSTNESTG 489
            |..|     .:::|     |.:||||:.:||:.|:...|.||:|.:. ....||..::| ....|
 Worm   416 LEEP-----FVIKT-----GENQYEGFCIDLLNEMTQVLKFNYTIIEVQDGTYGIEDES-GRWNG 469

  Fly   490 MLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPE--LFTFMDPFSEEV 552
            ::..:....|||:::.:|||..|.:.:|||:|||:|||:||..:..:.|.:  |:||::|.|..|
 Worm   470 IIGALQRHEADLSLSAVTITYSRAEVVDFTLPFMHLGISILLARTSEETDKGSLWTFLEPLSLTV 534

  Fly   553 WWFLGFSFLGVSLSFFILGRLSPSEWDNPYPCIEEPEELE--------NQFTLGNSIWFTTGALL 609
            |..|..|:..||.|..||.:.||.||.|    :|..:|.:        ||||:.||.|||.|:|:
 Worm   535 WISLLISYCIVSYSMHILAKFSPYEWYN----LERIDERDFENIKNQKNQFTVLNSFWFTMGSLM 595

  Fly   610 QQGSEIGPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVYGA 674
            ||||::.|:|.:||.:|..||.||.|::|||||.||||||:|:..:.|.|..||| |:..:.||.
 Worm   596 QQGSDVIPRAAATRLIAVVWWMFTQIIISSYTAQLAAFLTVERMSTPIESTQDLA-NQQKIRYGV 659

  Fly   675 KKTGSTRNFFMTSAEERYKKMNKFM-SENPQYLTEDNMEGVNRVKTNTHYAFLMESTSIEYNTKR 738
            .|:|||.:||..|....|::|...| |.:|......:.||:.|||:. .||::|||:.:||..:|
 Worm   660 LKSGSTMDFFRESKIPMYERMWSVMESSSPGVFVNSSREGIARVKSG-GYAYMMESSMLEYYLER 723

  Fly   739 ECNLKKIGDALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTGICATKEDA 803
            :|.|:.||..||.||||||:.|..|.|...:..:|:|||:.:||.:|||||.:...|.......:
 Worm   724 DCELQSIGGLLDSKGYGIALPKGSPLRDILSRTVLQLQERTILEALKNKWWRDRREGPSCGPPPS 788

  Fly   804 PDATPLDMNNLEGVFFVLLVGSCCALLYGIISWVLFVMKKAHHYRVPLRDALKEEFQFVIDFNNY 868
            ..||.....|:.|:|:|||.|...|.|.....:.:    ::.|      :|.:.:...|..|.::
 Worm   789 EKATNSKPQNIFGIFYVLLTGLIVAFLLACGEYCI----ESRH------EAFRLKLTIVGKFMDW 843

  Fly   869 VRVLKNSASIYSRSRQSSMSVASVAQE 895
            .|  .||.....||:..:|.:.:..||
 Worm   844 YR--GNSNDSKQRSKLRNMQLDTAGQE 868

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	40..402	CDD:380605	84/392 (21%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	154/382 (40%)
		Lig_chan	551..824	CDD:459656	121/281 (43%)
glr-4	NP_001254126.1	Periplasmic_Binding_Protein_type1	30..385	CDD:471960	84/389 (22%)
		Periplasmic_Binding_Protein_Type_2	410..775	CDD:473866	154/381 (40%)