DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and Grin3b

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_579842.2	Gene:	Grin3b / 170796	RGDID:	621705	Length:	1002	Species:	Rattus norvegicus

Alignment Length:	604	Identity:	141/604 - (23%)
Similarity:	242/604 - (40%)	Gaps:	109/604 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   307 ALTYDAVQLFAQTLKNL-------PFKPMPQNCSQ-RTESVRDDGSSFKNYMRTLRLTDRLLTGP 363
            |:.:|.|:|.||.|.::       ...|...||.. :|......|.:...::.......|  ||.
  Rat   291 AVVHDMVELVAQALSSMALVHPERALLPAVVNCDDLKTGGSEATGRTLARFLGNTSFQGR--TGA 353

  Fly   364 IYFEGN--VRKGYHLDVIELQ--PSGI---VKVGTWDEDR------------------QYRPQRL 403
            ::..|:  |....|..|..|:  |.|.   ..||:|.:.:                  |.||:..
  Rat   354 VWVTGSSQVHVSRHFKVWSLRRDPLGAPAWATVGSWQDGQLDFQPGAAALRVPSPSGTQARPKLR 418

  Fly   404 APTTAQFDSV-----------------------DNSLANKTFIILL--SVPNKPYAQLVETYKQL 443
            ..|..:...|                       |::..:..|..|:  |||        .|.::.
  Rat   419 VVTLVEHPFVFTRESDEDGQCPAGQLCLDPGTNDSARLDALFAALVNGSVP--------RTLRRC 475

  Fly   444 EGNSQYEGYGVDLIKELADKLGFNF-TFVNGGNDYGSYNKSTNESTGMLREIMTGRADLAITDLT 507
                 ..||.:||::.||:.|.|:| .::.|...||:..  ....||::.:::.|||.:|:|..:
  Rat   476 -----CYGYCIDLLERLAEDLAFDFELYIVGDGKYGALR--DGRWTGLVGDLLAGRAHMAVTSFS 533

  Fly   508 ITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLG-FSFLGVSLSFFILG 571
            |.|.|.|.:|||.||.:..:.|:......|:| :..||.|....:|  :| |:.|.::..|..|
  Rat   534 INSARSQVVDFTSPFFSTSLGIMVRTRDTASP-IGAFMWPLHWSMW--VGVFAALHLTALFLTL- 594

  Fly   572 RLSPSEWDNPYPCIEEPEELENQFTLGNSIWFTTGALL-QQGSEIGPKALSTRTVASFWWFFTLI 635
                .||.:||............|:..:::......|. :..|...||..:.|.:.:.|..|.|:
  Rat   595 ----YEWRSPYGLTPRGRNRGTVFSYSSALNLCYAILFGRTVSSKTPKCPTGRFLMNLWAIFCLL 655

  Fly   636 VVSSYTANLAAFLTIEKPQSLINSVDD--LADNKDGVVYGAKKTGSTRNFFMTSAEERYKKMNKF 698
            |:|||||||||.:..:|....::.:.|  |.....|..:|.....|...:...|..|.:..|.:.
  Rat   656 VLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPSQGFRFGTVWESSAEAYIKASFPEMHAHMRRH 720

  Fly   699 MSENPQY----LTEDNMEGVNRVKTNTHYAFLMESTSIEYNTK--RECNLKKIGDALDEKGYGIA 757
            .:....:    ||.|      ..|.|   ||:|:.:.::|...  .:|.|..:|.....:||||.
  Rat   721 SAPTTPHGVAMLTSD------PPKLN---AFIMDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIG 776

  Fly   758 MRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEV--GTGICATKEDAPDATPLDMNNLEGVFFV 820
            :.::.|.....:..:...:..|.::.:.:||:..|  |..:.|..|    ...:.:.:..|:|.:
  Rat   777 LPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVFAVTE----TLQMGVYHFSGLFVL 837

  Fly   821 LLVGSCCALLYGIISWVLF 839
            |.:|...|||..:...|.:
  Rat   838 LCLGLGSALLTSLGEHVFY 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	25/103 (24%)
		ANF_receptor	51..382	CDD:279440	19/84 (23%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	98/383 (26%)
		Lig_chan	551..824	CDD:278489	65/284 (23%)
Grin3b	NP_579842.2	PBP1_iGluR_NMDA_NR3	21..405	CDD:107372	25/115 (22%)
		PBP2_iGluR_NMDA_Nr3	414..808	CDD:270438	102/425 (24%)
		Lig_chan	576..842	CDD:278489	65/285 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	882..910
		Involved in the trafficking and surface expression of NMDARs. /evidence=ECO:0000250	951..984
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349884
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840