DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and gria3a

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	XP_005165152.1	Gene:	gria3a / 170452	ZFINID:	ZDB-GENE-020125-5	Length:	903	Species:	Danio rerio

Alignment Length:	933	Identity:	297/933 - (31%)
Similarity:	465/933 - (49%)	Gaps:	121/933 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 HISV---NWAQYENFGGYDNYQSLESVPIGLLTDQNTEQMNIVFDHAIDVANQEVGTSLTSLKEE 77
            |.||   .|...:...|:.|     .:.||.|..::|.|.:..|..|:.:.|  ...::|.....
Zfish     6 HASVLLLPWLVLQTQAGFPN-----QINIGGLFMRSTVQEHSAFRFAVQLYN--TNQNITEKPFH 63

  Fly    78 VNY-------GDAYQSYGKLCRMLETGIAGVFGPSSRHTAVHLMSICDAMDIPHIY-SYMSENAE 134
            :||       .:::......|.....|:..:||...|.:...|.|.|.|:....|. |:.::...
Zfish    64 LNYNVDNLESSNSFSVTHAFCSQFSRGVYAIFGFYDRRSMNTLTSFCGALHTSFITPSFPTDTDV 128

  Fly   135 GFNLHPHPADLAKALYSLITEFNWTRFIFLYESAEYLNIL---------NELTTMLGKSGTVITV 190
            .|.|...|: |..||.||:..:.|.:|::||::....:||         |.........|.::..
Zfish   129 QFVLQMRPS-LRGALLSLLAHYKWEKFVYLYDTDRGFSILQAIMESAVMNNWQVTARSVGNIVDP 192

  Fly   191 LRYDMQLNGNYKQVLRRVRKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIGNLDFHSFD 255
            |        .|::::..:.:..:.|.::....|.:...|.|....|..:..|.||:.||.|.:..
Zfish   193 L--------EYRRIIEEMDRRQEKRFLIDCEVERINSILEQVVIAGKNSRGYHYILANLGFTNMS 249

  Fly   256 LEEYKYSEANITGLRLFSPEKMAVKELLMKLGYPTDQDEF-RNGSCPITVEMALTYDAVQLFAQT 319
            |::.....|||||.::.:|:...|::.|.: ....|:.|| .:.|.|:....|||:||:.:.|:.
Zfish   250 LDKVFSGGANITGFQIINPDSPIVQQFLQR-WERLDEREFPESRSSPLKYTSALTHDAILVIAEA 313

  Fly   320 LKNLPFKPMPQNCSQRTESVR--DDGSSFKN----------YMRTLRLTD-RLLTGPIYFEG-NV 370
            .:.|.        .||.:..|  ..|....|          ..|.|::.. :.:||.|.|:. ..
Zfish   314 FRYLR--------RQRVDISRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDSFGR 370

  Fly   371 RKGYHLDVIELQPSGIVKVGTWDEDRQYRPQRLAPTTAQFDSVDNSLANKTFIILLSVPNKPYAQ 435
            |..|.:||.|::|.|..|:|.|:|..::    :.....|..:..:|:.|:| |::.::...||..
Zfish   371 RSNYTVDVYEMKPGGARKIGYWNEFEKF----VYIVEQQVTNESSSVENRT-IVVTTIMEAPYVM 430

  Fly   436 LVETYKQLEGNSQYEGYGVDLIKELADKLG--FNFTFVNGGNDYGSYNKSTNESTGMLREIMTGR 498
            ....|.|||||.:||||.|||..|:|..:|  :..:.|..|. ||:.:..|....||:.|::.||
Zfish   431 YKRNYMQLEGNDRYEGYCVDLASEIAKHVGIKYKLSIVADGK-YGARDPETKTWNGMVGELVYGR 494

  Fly   499 ADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLGFSFLGV 563
            ||:|:..||||..||:.:||:.|||:|||:|:..||||:.|.:|:|:||.:.|:|..:.|:::||
Zfish   495 ADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGV 559

  Fly   564 SLSFFILGRLSPSEW---DNPYPCIEE------PEELENQFTLGNSIWFTTGALLQQGSEIGPKA 619
            |:..|::.|.||.||   ||     ||      |.:..|.|.:.||:||:.||.:|||.:|.|::
Zfish   560 SVVLFLVSRFSPYEWHLDDN-----EETKDPQTPPDPPNDFGIFNSLWFSLGAFMQQGCDISPRS 619

  Fly   620 LSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVYGAKKTGSTRNFF 684
            ||.|.|...|||||||::||||||||||||:|:..|.|.|.:|||...: :.||...:|||:.||
Zfish   620 LSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTE-IAYGTLDSGSTKEFF 683

  Fly   685 MTSAEERYKKMNKFM-SENPQYLTEDNMEGVNRV-KTNTHYAFLMESTSIEYNTKRE-CNLKKIG 746
            ..|....|:||..:| |..|....:...:||.|| |:...:|||:|||..||..:|: |:..|:|
Zfish   684 RRSKIAVYEKMWSYMKSAEPSVFVKTTPDGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVG 748

  Fly   747 DALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTGICATKEDAPDA----- 806
            ..||.||||:|..|....|...|.|:|:|.|||:|:|:|||||.:.|.  |.||:.....
Zfish   749 GNLDSKGYGVATPKGSALRTPVNLAVLKLSEQGILDKLKNKWWYDKGE--CGTKDSGSKVSLLTH 811

  Fly   807 -TPLDMN-----------NLEGVFF---VLLVGSCC-ALLYGII--SWVLFVMKK------AHHY 847
             |.|..|           .:.|..|   :.::.:|. |:::.::  |..|.:|::      :|..
Zfish   812 LTVLPTNISIYHKHHNEFPVAGFTFFWPLFILFTCAQAIMHHVVRKSQPLALMRQHNRCTHSHRR 876

  Fly   848 RVPLRDALKEEFQ-FVIDFNNYV 869
            |.   |.|.:..| |:|.:.|.|
Zfish   877 RC---DMLTKHLQVFIIHYFNDV 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	93/385 (24%)
		ANF_receptor	51..382	CDD:279440	84/362 (23%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	171/384 (45%)
		Lig_chan	551..824	CDD:278489	123/304 (40%)
gria3a	XP_005165152.1	PBP1_iGluR_AMPA_GluR3	28..399	CDD:107382	94/394 (24%)
		ANF_receptor	39..382	CDD:279440	84/362 (23%)
		PBP2_iGluR_AMPA	415..797	CDD:270433	173/391 (44%)
		Lig_chan	547..810	CDD:278489	118/270 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591346
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.750