Protein Alignment GluRIIE and Grin2b

DIOPT Version :10

• Sequence 1: NP_001036733.1
• Gene: GluRIIE / 318623
• FlyBaseID: FBgn0051201
• Length: 897
• Species: Drosophila melanogaster
• Sequence 2: NP_032197.3
• Gene: Grin2b / 14812
• MGIID: 95821
• Length: 1482
• Species: Mus musculus
• Alignment Length: 898
• Identity: 203/898 - (22%)
• Similarity: 369/898 - (41%)
• Gaps: 189/898 - (21%)

  Fly    31 DNYQSLESVP-IGLLTDQNTEQMNIVFDHAIDVANQEVGTSLTSLKEE------VNYGDAYQSYG 88
            |::..|..|| :.|:....|:..:|:             |.:..|..:      |...|..|.
Mouse    57 DDFHHLSVVPRVELVAMNETDPKSII-------------TRICDLMSDRKIQGVVFADDTDQE-- 106

  Fly    89 KLCRMLE-------TGIAGVFGPSSRHTAVHLMSICDAMDIPHIYSYMSENAEGFNLHPHPADLA 146
            .:.::|:       |.|.|:.|.||       |.:.|          ..|::..|...|.....|
Mouse   107 AIAQILDFISAQTLTPILGIHGGSS-------MIMAD----------KDESSMFFQFGPSIEQQA 154

  Fly   147 KALYSLITEFNWTRFIFLYESA---EYLNILNELTTMLGKS---GTVITVLRYDMQLNGNYKQVL 205
            ..:.:::.|::|  :||...:.   .|.:.:|::.:.:..|   ..:..||..||.|:....::.
Mouse   155 SVMLNIMEEYDW--YIFSIVTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQ 217

  Fly   206 RRVRKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIGNLDFHSFDLEEYKYSEANITGLR 270
            .:::|.....|::..:.|........|..||:....|.:|:.:|.....|....::.    |||.
Mouse   218 NQLKKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPSEFP----TGLI 278

  Fly   271 LFSPEKMAVKELLMKLGYPTDQDEFRNGSCPITVEMALTYDAVQLFAQTLKNLPFKPMPQNCSQR 335
            ..|.::       ...|.|.   ..|:|...||...          :..|....|.|.|::....
Mouse   279 SVSYDE-------WDYGLPA---RVRDGIAIITTAA----------SDMLSEHSFIPEPKSSCYN 323

  Fly   336 TESVRDDGSSFKNYMRTLRLTDRLLTGPIYFEGNVRKGYHLDVIELQPSGIV----------KVG 390
            |...|...|:..|         |.|.. :.|||. ...:..|..::.|..::          :||
Mouse   324 THEKRIYQSNMLN---------RYLIN-VTFEGR-NLSFSEDGYQMHPKLVIILLNKERKWERVG 377

  Fly   391 TWDED----RQYRPQRLAPTTAQFDSVDNSLANKTFIILLSVPNKPYAQLVETYKQLEGNSQ--- 448
            .|.:.    :.|...|:.|.|.:.:  |:.|:      ::::...|:. :||:...|.|...
Mouse   378 KWKDKSLQMKYYVWPRMCPETEEQE--DDHLS------IVTLEEAPFV-IVESVDPLSGTCMRNT 433

  Fly   449 -----------------------YEGYGVDLIKELADKLGFNFTFVNGGNDYGSYNKSTNES-TG 489
                                   .:|:.:|::|:::..:.|.:......|  |.:.|..|.: .|
Mouse   434 VPCQKRIISENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTN--GKHGKKINGTWNG 496

  Fly   490 MLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWW 554
            |:.|::..||.:|:..|||..||.:.:||::||:..||::: :.....|.....|::|||.:||.
Mouse   497 MIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVM-VSRSNGTVSPSAFLEPFSADVWV 560

  Fly   555 FLGFSFLGVS-LSFFILGRLSPSEWDNPYPCIEEPEELEN-QFTLGNSIWFTTGALLQQGSEI-G 616
            .:....|.|| ::.|:....||..::.   |:.:..|... .||:|.:||...|.:......: .
Mouse   561 MMFVMLLIVSAVAVFVFEYFSPVGYNR---CLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQN 622

  Fly   617 PKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNK--------DGVVYG 673
            ||..:::.:.|.|.||.:|.::|||||||||:..|:   .::.|..|:|.|        ....:|
Mouse   623 PKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEE---YVDQVSGLSDKKFQRPNDFSPPFRFG 684

  Fly   674 AKKTGSTRNFFMTSAEERYKKMNKFMSENPQYLTEDNMEGVN----RVKTNTHYAFLMESTSIEY 734
            ....|||......:..|.:..|.||           |..||:    .:||....||:.::..:.|
Mouse   685 TVPNGSTERNIRNNYAEMHAYMGKF-----------NQRGVDDALLSLKTGKLDAFIYDAAVLNY 738

  Fly   735 NTKRE--CNLKKIGD--ALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTG 795
            ...|:  |.|..||.  .....|||||::||...:.:.:.|:|:|...|.:|:::..|.    ||
Mouse   739 MAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWL----TG 799

  Fly   796 ICATKEDAPDATPLDMNNLEGVFFVLLVGSCCALLYGIISWVLFVMKKAHHYR 848
            ||..:::...::.||::|:.|||::|  |:..||     |.:.|:.:...:::
Mouse   800 ICHNEKNEVMSSQLDIDNMAGVFYML--GAAMAL-----SLITFICEHLFYWQ 845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	40..402	CDD:380605	73/395 (18%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	106/416 (25%)
		Lig_chan	551..824	CDD:459656	82/291 (28%)
Grin2b	NP_032197.3	PBP1_iGluR_NMDA_NR2	33..388	CDD:380601	75/399 (19%)
		PBP2_iGluR_NMDA_Nr2	403..803	CDD:270436	112/430 (26%)
		NMDAR2_C	840..1482	CDD:463148	0/6 (0%)