DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and Grin2b

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_001350679.1	Gene:	Grin2b / 14812	MGIID:	95821	Length:	1482	Species:	Mus musculus

Alignment Length:	898	Identity:	203/898 - (22%)
Similarity:	369/898 - (41%)	Gaps:	189/898 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 DNYQSLESVP-IGLLTDQNTEQMNIVFDHAIDVANQEVGTSLTSLKEE------VNYGDAYQSYG 88
            |::..|..|| :.|:....|:..:|:             |.:..|..:      |...|..|.
Mouse    57 DDFHHLSVVPRVELVAMNETDPKSII-------------TRICDLMSDRKIQGVVFADDTDQE-- 106

  Fly    89 KLCRMLE-------TGIAGVFGPSSRHTAVHLMSICDAMDIPHIYSYMSENAEGFNLHPHPADLA 146
            .:.::|:       |.|.|:.|.||       |.:.|          ..|::..|...|.....|
Mouse   107 AIAQILDFISAQTLTPILGIHGGSS-------MIMAD----------KDESSMFFQFGPSIEQQA 154

  Fly   147 KALYSLITEFNWTRFIFLYESA---EYLNILNELTTMLGKS---GTVITVLRYDMQLNGNYKQVL 205
            ..:.:::.|::|  :||...:.   .|.:.:|::.:.:..|   ..:..||..||.|:....::.
Mouse   155 SVMLNIMEEYDW--YIFSIVTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQ 217

  Fly   206 RRVRKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIGNLDFHSFDLEEYKYSEANITGLR 270
            .:::|.....|::..:.|........|..||:....|.:|:.:|.....|....::.    |||.
Mouse   218 NQLKKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPSEFP----TGLI 278

  Fly   271 LFSPEKMAVKELLMKLGYPTDQDEFRNGSCPITVEMALTYDAVQLFAQTLKNLPFKPMPQNCSQR 335
            ..|.::       ...|.|.   ..|:|...||...          :..|....|.|.|::....
Mouse   279 SVSYDE-------WDYGLPA---RVRDGIAIITTAA----------SDMLSEHSFIPEPKSSCYN 323

  Fly   336 TESVRDDGSSFKNYMRTLRLTDRLLTGPIYFEGNVRKGYHLDVIELQPSGIV----------KVG 390
            |...|...|:..|         |.|.. :.|||. ...:..|..::.|..::          :||
Mouse   324 THEKRIYQSNMLN---------RYLIN-VTFEGR-NLSFSEDGYQMHPKLVIILLNKERKWERVG 377

  Fly   391 TWDED----RQYRPQRLAPTTAQFDSVDNSLANKTFIILLSVPNKPYAQLVETYKQLEGNSQ--- 448
            .|.:.    :.|...|:.|.|.:.:  |:.|:      ::::...|:. :||:...|.|...
Mouse   378 KWKDKSLQMKYYVWPRMCPETEEQE--DDHLS------IVTLEEAPFV-IVESVDPLSGTCMRNT 433

  Fly   449 -----------------------YEGYGVDLIKELADKLGFNFTFVNGGNDYGSYNKSTNES-TG 489
                                   .:|:.:|::|:::..:.|.:......|  |.:.|..|.: .|
Mouse   434 VPCQKRIISENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTN--GKHGKKINGTWNG 496

  Fly   490 MLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWW 554
            |:.|::..||.:|:..|||..||.:.:||::||:..||::: :.....|.....|::|||.:||.
Mouse   497 MIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVM-VSRSNGTVSPSAFLEPFSADVWV 560

  Fly   555 FLGFSFLGVS-LSFFILGRLSPSEWDNPYPCIEEPEELEN-QFTLGNSIWFTTGALLQQGSEI-G 616
            .:....|.|| ::.|:....||..::.   |:.:..|... .||:|.:||...|.:......: .
Mouse   561 MMFVMLLIVSAVAVFVFEYFSPVGYNR---CLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQN 622

  Fly   617 PKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNK--------DGVVYG 673
            ||..:::.:.|.|.||.:|.::|||||||||:..|:   .::.|..|:|.|        ....:|
Mouse   623 PKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEE---YVDQVSGLSDKKFQRPNDFSPPFRFG 684

  Fly   674 AKKTGSTRNFFMTSAEERYKKMNKFMSENPQYLTEDNMEGVN----RVKTNTHYAFLMESTSIEY 734
            ....|||......:..|.:..|.||           |..||:    .:||....||:.::..:.|
Mouse   685 TVPNGSTERNIRNNYAEMHAYMGKF-----------NQRGVDDALLSLKTGKLDAFIYDAAVLNY 738

  Fly   735 NTKRE--CNLKKIGD--ALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTG 795
            ...|:  |.|..||.  .....|||||::||...:.:.:.|:|:|...|.:|:::..|.    ||
Mouse   739 MAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWL----TG 799

  Fly   796 ICATKEDAPDATPLDMNNLEGVFFVLLVGSCCALLYGIISWVLFVMKKAHHYR 848
            ||..:::...::.||::|:.|||::|  |:..||     |.:.|:.:...:::
Mouse   800 ICHNEKNEVMSSQLDIDNMAGVFYML--GAAMAL-----SLITFICEHLFYWQ 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	71/386 (18%)
		ANF_receptor	51..382	CDD:279440	65/349 (19%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	106/416 (25%)
		Lig_chan	551..824	CDD:278489	82/291 (28%)
Grin2b	NP_001350679.1	PBP1_iGluR_NMDA_NR2	33..388	CDD:380601	75/399 (19%)
		PBP2_iGluR_NMDA_Nr2	403..803	CDD:270436	112/430 (26%)
		NMDAR2_C	840..1482	CDD:402274	0/6 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846373
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840