Protein Alignment GluRIIE and Grin2a

DIOPT Version :9

• Sequence 1: NP_001036733.1
• Gene: GluRIIE / 318623
• FlyBaseID: FBgn0051201
• Length: 897
• Species: Drosophila melanogaster
• Sequence 2: NP_032196.2
• Gene: Grin2a / 14811
• MGIID: 95820
• Length: 1464
• Species: Mus musculus
• Alignment Length: 992
• Identity: 228/992 - (22%)
• Similarity: 397/992 - (40%)
• Gaps: 248/992 - (25%)

  Fly    46 DQNTEQMNI--VFDHAIDVANQEVGT-----SLTSLKEEVNY-------GDAYQSYGKLCRMLE- 95
            ::.|..:||  :..|:.||..:|:..     ..|.|..:||.       .|.......:|.::.
Mouse    28 EKGTPALNIAVLLGHSHDVTERELRNLWGPEQATGLPLDVNVVALLMNRTDPKSLITHVCDLMSG 92

  Fly    96 TGIAG-VFGPSSRHTAVHLM--SICDAMDIP----H-----IYSYMSENAEGFNLHPHPADLAKA 148
            ..|.| |||..:...||..|  .|.....||    |     |.:.....:..|.........|..
Mouse    93 ARIHGLVFGDDTDQEAVAQMLDFISSQTFIPILGIHGGASMIMADKDPTSTFFQFGASIQQQATV 157

  Fly   149 LYSLITEFNWTRF-----IFLYESAEYLNILNELTTMLGKSGTVITVLRYDMQ----LNGNYKQV 204
            :..::.:::|..|     ||    ..|.:.::.:.|.:..|     .:.:|||    |:.:::..
Mouse   158 MLKIMQDYDWHVFSLVTTIF----PGYRDFISFIKTTVDNS-----FVGWDMQNVITLDTSFEDA 213

  Fly   205 -----LRRVRKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYII-----GNLD--------- 250
                 |:::..||   |::..|.:.....|::|:.:|:...|:.:|:     ||.:
Mouse   214 KTQVQLKKIHSSV---ILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSG 275

  Fly   251 FHSFDLEEYKYS-EANI-TGLRLFSPEKMAVKELLMKLGYPTDQDEFRNGSCPITVEMALTYDAV 313
            ..|...:::.|| ||.: .||.:.:   .|...:|.|..|..:    ...||
Mouse   276 LISVSYDDWDYSLEARVRDGLGILT---TAASSMLEKFSYIPE----AKASC------------- 320

  Fly   314 QLFAQTLKNLPFKPMPQNCSQRTESVRDDGSSFKNYMRTLRLTDRLLTGPIYFEGNVRKGYHLDV 378
              :.||.|  |..|: ....|...:|..||       :.|..|:              :||
Mouse   321 --YGQTEK--PETPL-HTLHQFMVNVTWDG-------KDLSFTE--------------EGY---- 355

  Fly   379 IELQPSGIV----------KVGTWDEDRQYRPQRLAPTTAQFDSV---DNSLANKT-----FIIL 425
             ::.|..:|          |||.|:.........:.|....|...   ||.|:..|     |:|:
Mouse   356 -QVHPRLVVIVLNKDREWEKVGKWENQTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIV 419

  Fly   426 ------------LSVPNKPYAQLVETYKQLEGNSQYE---------GYGVDLIKELADKLGFNFT 469
                        .:||.:.:.::        .||..|         |:.:|::|:|:..:.|.:.
Mouse   420 EDIDPLTETCVRNTVPCRKFVKI--------NNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYD 476

  Fly   470 FVNGGNDYGSYNKSTNES-TGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLK 533
            .....|  |.:.|..|.. .||:.|::..||.:|:..|||..||.:.:||::||:..||::: :.
Mouse   477 LYLVTN--GKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVM-VS 538

  Fly   534 PQKATPELFTFMDPFSEEVWWFLGFSFLGVS-LSFFILGRLSPSEWDNPYPCIEEPEELENQFTL 597
            ....|.....|::|||..||..:....|.|| ::.|:....||..::......:.|.  ...||:
Mouse   539 RSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPH--GPSFTI 601

  Fly   598 GNSIWFTTGALLQQGSEI-GPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVD 661
            |.:||...|.:......: .||..:::.:.|.|.||.:|.::|||||||||:..|:   .::.|.
Mouse   602 GKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEE---FVDQVT 663

  Fly   662 DLADNK--------DGVVYGAKKTGST-RNFFMTSAEERYKKMNKFMSENPQYLTEDNMEGVN-- 715
            .|:|.|        ....:|....||| ||.     ...|..|:       ||:|:.|..||.
Mouse   664 GLSDKKFQRPHDYSPPFRFGTVPNGSTERNI-----RNNYPYMH-------QYMTKFNQRGVEDA 716

  Fly   716 --RVKTNTHYAFLMESTSIEYNTKRE--CNLKKIGDA--LDEKGYGIAMRKDWPHRGKFNNALLE 774
              .:||....||:.::..:.|...|:  |.|..||..  ....|||||::|..|.:.:.:.|||:
Mouse   717 LVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQ 781

  Fly   775 LQEQGVLEKMKNKWWNEVGTGICATKEDAPDATPLDMNNLEGVFFVLLVGSCCALL--------- 830
            ....|.:|:::..|.    ||||..:::...::.||::|:.|||::|......:|:
Mouse   782 FVGDGEMEELETLWL----TGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFY 842

  Fly   831 -------YGIIS---WVLFVMKKA-----HHYRVPLRDALKEEFQFVIDFN------NYVRVLKN 874
                   .|:.|   .:||.:.:.     |...:       ||.:...|||      |.:::|::
Mouse   843 WKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHI-------EEKKKSPDFNLTGSQSNMLKLLRS 900

  Fly   875 SASIYSRSRQSSMSVAS 891
            :.:|.:.|..:|..:.|
Mouse   901 AKNISNMSNMNSSRMDS 917

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	83/416 (20%)
		ANF_receptor	51..382	CDD:279440	76/387 (20%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	112/416 (27%)
		Lig_chan	551..824	CDD:278489	84/291 (29%)
Grin2a	NP_032196.2	PBP1_iGluR_NMDA_NR2	32..392	CDD:107373	82/422 (19%)
		PBP2_iGluR_NMDA_Nr2	403..802	CDD:270436	119/430 (28%)
		HisJ	<458..>541	CDD:223904	26/85 (31%)
		Lig_chan	556..828	CDD:278489	84/292 (29%)
		NMDAR2_C	839..1464	CDD:287527	16/86 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846376
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840