Protein Alignment GluRIIE and Grin2a

DIOPT Version :10

• Sequence 1: NP_001036733.1
• Gene: GluRIIE / 318623
• FlyBaseID: FBgn0051201
• Length: 897
• Species: Drosophila melanogaster
• Sequence 2: NP_032196.2
• Gene: Grin2a / 14811
• MGIID: 95820
• Length: 1464
• Species: Mus musculus
• Alignment Length: 992
• Identity: 228/992 - (22%)
• Similarity: 397/992 - (40%)
• Gaps: 248/992 - (25%)

  Fly    46 DQNTEQMNI--VFDHAIDVANQEVGT-----SLTSLKEEVNY-------GDAYQSYGKLCRMLE- 95
            ::.|..:||  :..|:.||..:|:..     ..|.|..:||.       .|.......:|.::.
Mouse    28 EKGTPALNIAVLLGHSHDVTERELRNLWGPEQATGLPLDVNVVALLMNRTDPKSLITHVCDLMSG 92

  Fly    96 TGIAG-VFGPSSRHTAVHLM--SICDAMDIP----H-----IYSYMSENAEGFNLHPHPADLAKA 148
            ..|.| |||..:...||..|  .|.....||    |     |.:.....:..|.........|..
Mouse    93 ARIHGLVFGDDTDQEAVAQMLDFISSQTFIPILGIHGGASMIMADKDPTSTFFQFGASIQQQATV 157

  Fly   149 LYSLITEFNWTRF-----IFLYESAEYLNILNELTTMLGKSGTVITVLRYDMQ----LNGNYKQV 204
            :..::.:::|..|     ||    ..|.:.::.:.|.:..|     .:.:|||    |:.:::..
Mouse   158 MLKIMQDYDWHVFSLVTTIF----PGYRDFISFIKTTVDNS-----FVGWDMQNVITLDTSFEDA 213

  Fly   205 -----LRRVRKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYII-----GNLD--------- 250
                 |:::..||   |::..|.:.....|::|:.:|:...|:.:|:     ||.:
Mouse   214 KTQVQLKKIHSSV---ILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSG 275

  Fly   251 FHSFDLEEYKYS-EANI-TGLRLFSPEKMAVKELLMKLGYPTDQDEFRNGSCPITVEMALTYDAV 313
            ..|...:::.|| ||.: .||.:.:   .|...:|.|..|..:    ...||
Mouse   276 LISVSYDDWDYSLEARVRDGLGILT---TAASSMLEKFSYIPE----AKASC------------- 320

  Fly   314 QLFAQTLKNLPFKPMPQNCSQRTESVRDDGSSFKNYMRTLRLTDRLLTGPIYFEGNVRKGYHLDV 378
              :.||.|  |..|: ....|...:|..||       :.|..|:              :||
Mouse   321 --YGQTEK--PETPL-HTLHQFMVNVTWDG-------KDLSFTE--------------EGY---- 355

  Fly   379 IELQPSGIV----------KVGTWDEDRQYRPQRLAPTTAQFDSV---DNSLANKT-----FIIL 425
             ::.|..:|          |||.|:.........:.|....|...   ||.|:..|     |:|:
Mouse   356 -QVHPRLVVIVLNKDREWEKVGKWENQTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIV 419

  Fly   426 ------------LSVPNKPYAQLVETYKQLEGNSQYE---------GYGVDLIKELADKLGFNFT 469
                        .:||.:.:.::        .||..|         |:.:|::|:|:..:.|.:.
Mouse   420 EDIDPLTETCVRNTVPCRKFVKI--------NNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYD 476

  Fly   470 FVNGGNDYGSYNKSTNES-TGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLK 533
            .....|  |.:.|..|.. .||:.|::..||.:|:..|||..||.:.:||::||:..||::: :.
Mouse   477 LYLVTN--GKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVM-VS 538

  Fly   534 PQKATPELFTFMDPFSEEVWWFLGFSFLGVS-LSFFILGRLSPSEWDNPYPCIEEPEELENQFTL 597
            ....|.....|::|||..||..:....|.|| ::.|:....||..::......:.|.  ...||:
Mouse   539 RSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPH--GPSFTI 601

  Fly   598 GNSIWFTTGALLQQGSEI-GPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVD 661
            |.:||...|.:......: .||..:::.:.|.|.||.:|.::|||||||||:..|:   .::.|.
Mouse   602 GKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEE---FVDQVT 663

  Fly   662 DLADNK--------DGVVYGAKKTGST-RNFFMTSAEERYKKMNKFMSENPQYLTEDNMEGVN-- 715
            .|:|.|        ....:|....||| ||.     ...|..|:       ||:|:.|..||.
Mouse   664 GLSDKKFQRPHDYSPPFRFGTVPNGSTERNI-----RNNYPYMH-------QYMTKFNQRGVEDA 716

  Fly   716 --RVKTNTHYAFLMESTSIEYNTKRE--CNLKKIGDA--LDEKGYGIAMRKDWPHRGKFNNALLE 774
              .:||....||:.::..:.|...|:  |.|..||..  ....|||||::|..|.:.:.:.|||:
Mouse   717 LVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQ 781

  Fly   775 LQEQGVLEKMKNKWWNEVGTGICATKEDAPDATPLDMNNLEGVFFVLLVGSCCALL--------- 830
            ....|.:|:::..|.    ||||..:::...::.||::|:.|||::|......:|:
Mouse   782 FVGDGEMEELETLWL----TGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFY 842

  Fly   831 -------YGIIS---WVLFVMKKA-----HHYRVPLRDALKEEFQFVIDFN------NYVRVLKN 874
                   .|:.|   .:||.:.:.     |...:       ||.:...|||      |.:::|::
Mouse   843 WKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHI-------EEKKKSPDFNLTGSQSNMLKLLRS 900

  Fly   875 SASIYSRSRQSSMSVAS 891
            :.:|.:.|..:|..:.|
Mouse   901 AKNISNMSNMNSSRMDS 917

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	40..402	CDD:380605	83/422 (20%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	112/416 (27%)
		Lig_chan	551..824	CDD:459656	84/291 (29%)
Grin2a	NP_032196.2	PBP1_iGluR_NMDA_NR2	32..387	CDD:380601	82/417 (20%)
		PBP2_iGluR_NMDA_Nr2	403..802	CDD:270436	119/430 (28%)
		NMDAR2_C	839..1464	CDD:463148	16/86 (19%)