Protein Alignment GluRIIE and Grik1

DIOPT Version :10

• Sequence 1: NP_001036733.1
• Gene: GluRIIE / 318623
• FlyBaseID: FBgn0051201
• Length: 897
• Species: Drosophila melanogaster
• Sequence 2: NP_001391957.1
• Gene: Grik1 / 14805
• MGIID: 95814
• Length: 949
• Species: Mus musculus
• Alignment Length: 944
• Identity: 329/944 - (34%)
• Similarity: 491/944 - (52%)
• Gaps: 127/944 - (13%)

  Fly    23 QYENFGGYDNYQSLESVPIGLLTDQNTEQMNIVFDHAIDVANQE----VGTSLTSLKEEVNYGDA 83
            |....||.  ::::|:.|:      |.|:  :.|..|:...|:.    ..|:||...:.:|..|:
Mouse    35 QVLRIGGI--FETVENEPV------NVEE--LAFKFAVTSINRNRTLMPNTTLTYDIQRINLFDS 89

  Fly    84 YQSYGKLCRMLETGIAGVFGPSSRHTAVHLMSICDAMDIPHIYSYMS----ENAEGF--NLHPHP 142
            :::..:.|..|..|:|.:||||...:...:.|||:|:::|||.:...    :|.:.|  ||:|..
Mouse    90 FEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNRDLFYINLYPDY 154

  Fly   143 ADLAKALYSLITEFNWTRFIFLYESAEYLNILNELTTMLGKSGTVITVLRYDMQL--------NG 199
            |.:::|:..|:..:||.....:||.:..|..|.||         :....||::::        |.
Mouse   155 AAISRAVLDLVLYYNWKTVTVVYEDSTGLIRLQEL---------IKAPSRYNIKIKIRQLPSGNK 210

  Fly   200 NYKQVLRRVRKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIGNLDFHSFDLEEYKYSEA 264
            :.|.:|:.::|..:..::...|.||..|.|.|...:|::.|.|.|....||..:.|||.|:||..
Mouse   211 DAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGV 275

  Fly   265 NITGLRLFSPEKMAVKELLMKLGY------PTDQDEFRNGSCPITVEMALTYDAV---------- 313
            |:||.||.:.:...|..::.|...      |..:....:|  .:|.|.||.||||
Mouse   276 NMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDG--VMTTEAALMYDAVYMVAIASHRA 338

  Fly   314 -QLFAQTLKNLPFKPMPQNCSQRTESVRDDGSSFKNYMRTLRLTDRLLTGPIYFE--GNVRKGYH 375
             ||...:|:....||...            |..|.|.::..|...  |||.|.|.  ..:||.:.
Mouse   339 SQLTVSSLQCHRHKPWRL------------GPRFMNLIKEARWDG--LTGRITFNKTDGLRKDFD 389

  Fly   376 LDVIELQPSGI---------------VKVGTWDEDRQYRPQRLAPTTAQFD---SVDNSLANKTF 422
            ||:|.|:..|.               .|:|.|:.:     ..|..|....|   ::.:||||:|
Mouse   390 LDIISLKEEGTEKASGEVSKHLYKVWKKIGIWNSN-----SGLNMTDGNRDRSNNITDSLANRT- 448

  Fly   423 IILLSVPNKPYAQLVETYKQLEGNSQYEGYGVDLIKELADKLGF--NFTFVNGGNDYGSYNKSTN 485
            :|:.::..:||....::.|.|.||.::|||.:||:|||::.|||  :...|..|. ||:.| ...
Mouse   449 LIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGK-YGAQN-DKG 511

  Fly   486 ESTGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSE 550
            |..||::|::..|||||:..||||..||:.:||:.|||.|||:|||.||....|.:|:|::|.|.
Mouse   512 EWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSP 576

  Fly   551 EVWWFLGFSFLGVSLSFFILGRLSPSEWDNPYPCIEEPEELENQFTLGNSIWFTTGALLQQGSEI 615
            ::|.::..:.||||...|::.|.:|.||.||:||..:.:.:||.|||.||.||..|||:|||||:
Mouse   577 DIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSEL 641

  Fly   616 GPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVYGAKKTGST 680
            .|||||||.|...|||||||::||||||||||||:|:.:|.|:|.|||| .:..:.|||.:.|||
Mouse   642 MPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLA-KQTKIEYGAVRDGST 705

  Fly   681 RNFFMTSAEERYKKMNKFMSENPQ-YLTEDNMEGVNRVKTNTHYAFLMESTSIEYNTKRECNLKK 744
            ..||..|....|:||..|||...| .|.:::.||:.||.| |.||.|||||||||.|:|.|||.:
Mouse   706 MTFFKKSKISTYEKMWAFMSSRQQSALVKNSDEGIQRVLT-TDYALLMESTSIEYVTQRNCNLTQ 769

  Fly   745 IGDALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTGICATKEDAPDATPL 809
            ||..:|.||||:......|:|.|...|:|:|||:|.|..||.|||.  |.|  ..:||:.:|:.|
Mouse   770 IGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWR--GNG--CPEEDSKEASAL 830

  Fly   810 DMNNLEGVFFVLLVGSCCALLYGIISWVLFVMK--------KAHHYRVPLRDAL-----KEE--- 858
            .:.|:.|:|.||..|...::...|..::....|        |:...|...|:.:     |.|
Mouse   831 GVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNNDIEQKGKSSRLRFYFRNKVRFHGSKTESLG 895

  Fly   859 FQFVIDFNNYVR----VLKNSASIYSRSRQSSMS 888
            .:..:.||..:.    .|||...:..:||....|
Mouse   896 VEKCLSFNAIMEELGISLKNQKKLKKKSRTKGKS 929

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	40..402	CDD:380605	107/413 (26%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	184/373 (49%)
		Lig_chan	551..824	CDD:459656	138/273 (51%)
Grik1	NP_001391957.1	PBP1_iGluR_Kainate	38..431	CDD:380605	111/432 (26%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:473866	184/373 (49%)