DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and Grik1

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	XP_006522977.1	Gene:	Grik1 / 14805	MGIID:	95814	Length:	949	Species:	Mus musculus

Alignment Length:	944	Identity:	329/944 - (34%)
Similarity:	491/944 - (52%)	Gaps:	127/944 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 QYENFGGYDNYQSLESVPIGLLTDQNTEQMNIVFDHAIDVANQE----VGTSLTSLKEEVNYGDA 83
            |....||.  ::::|:.|:      |.|:  :.|..|:...|:.    ..|:||...:.:|..|:
Mouse    35 QVLRIGGI--FETVENEPV------NVEE--LAFKFAVTSINRNRTLMPNTTLTYDIQRINLFDS 89

  Fly    84 YQSYGKLCRMLETGIAGVFGPSSRHTAVHLMSICDAMDIPHIYSYMS----ENAEGF--NLHPHP 142
            :::..:.|..|..|:|.:||||...:...:.|||:|:::|||.:...    :|.:.|  ||:|..
Mouse    90 FEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNRDLFYINLYPDY 154

  Fly   143 ADLAKALYSLITEFNWTRFIFLYESAEYLNILNELTTMLGKSGTVITVLRYDMQL--------NG 199
            |.:::|:..|:..:||.....:||.:..|..|.||         :....||::::        |.
Mouse   155 AAISRAVLDLVLYYNWKTVTVVYEDSTGLIRLQEL---------IKAPSRYNIKIKIRQLPSGNK 210

  Fly   200 NYKQVLRRVRKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIGNLDFHSFDLEEYKYSEA 264
            :.|.:|:.::|..:..::...|.||..|.|.|...:|::.|.|.|....||..:.|||.|:||..
Mouse   211 DAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGV 275

  Fly   265 NITGLRLFSPEKMAVKELLMKLGY------PTDQDEFRNGSCPITVEMALTYDAV---------- 313
            |:||.||.:.:...|..::.|...      |..:....:|  .:|.|.||.||||
Mouse   276 NMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDG--VMTTEAALMYDAVYMVAIASHRA 338

  Fly   314 -QLFAQTLKNLPFKPMPQNCSQRTESVRDDGSSFKNYMRTLRLTDRLLTGPIYFE--GNVRKGYH 375
             ||...:|:....||...            |..|.|.::..|...  |||.|.|.  ..:||.:.
Mouse   339 SQLTVSSLQCHRHKPWRL------------GPRFMNLIKEARWDG--LTGRITFNKTDGLRKDFD 389

  Fly   376 LDVIELQPSGI---------------VKVGTWDEDRQYRPQRLAPTTAQFD---SVDNSLANKTF 422
            ||:|.|:..|.               .|:|.|:.:     ..|..|....|   ::.:||||:|
Mouse   390 LDIISLKEEGTEKASGEVSKHLYKVWKKIGIWNSN-----SGLNMTDGNRDRSNNITDSLANRT- 448

  Fly   423 IILLSVPNKPYAQLVETYKQLEGNSQYEGYGVDLIKELADKLGF--NFTFVNGGNDYGSYNKSTN 485
            :|:.::..:||....::.|.|.||.::|||.:||:|||::.|||  :...|..|. ||:.| ...
Mouse   449 LIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGK-YGAQN-DKG 511

  Fly   486 ESTGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSE 550
            |..||::|::..|||||:..||||..||:.:||:.|||.|||:|||.||....|.:|:|::|.|.
Mouse   512 EWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSP 576

  Fly   551 EVWWFLGFSFLGVSLSFFILGRLSPSEWDNPYPCIEEPEELENQFTLGNSIWFTTGALLQQGSEI 615
            ::|.::..:.||||...|::.|.:|.||.||:||..:.:.:||.|||.||.||..|||:|||||:
Mouse   577 DIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSEL 641

  Fly   616 GPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVYGAKKTGST 680
            .|||||||.|...|||||||::||||||||||||:|:.:|.|:|.|||| .:..:.|||.:.|||
Mouse   642 MPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLA-KQTKIEYGAVRDGST 705

  Fly   681 RNFFMTSAEERYKKMNKFMSENPQ-YLTEDNMEGVNRVKTNTHYAFLMESTSIEYNTKRECNLKK 744
            ..||..|....|:||..|||...| .|.:::.||:.||.| |.||.|||||||||.|:|.|||.:
Mouse   706 MTFFKKSKISTYEKMWAFMSSRQQSALVKNSDEGIQRVLT-TDYALLMESTSIEYVTQRNCNLTQ 769

  Fly   745 IGDALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTGICATKEDAPDATPL 809
            ||..:|.||||:......|:|.|...|:|:|||:|.|..||.|||.  |.|  ..:||:.:|:.|
Mouse   770 IGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWR--GNG--CPEEDSKEASAL 830

  Fly   810 DMNNLEGVFFVLLVGSCCALLYGIISWVLFVMK--------KAHHYRVPLRDAL-----KEE--- 858
            .:.|:.|:|.||..|...::...|..::....|        |:...|...|:.:     |.|
Mouse   831 GVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNNDIEQKGKSSRLRFYFRNKVRFHGSKTESLG 895

  Fly   859 FQFVIDFNNYVR----VLKNSASIYSRSRQSSMS 888
            .:..:.||..:.    .|||...:..:||....|
Mouse   896 VEKCLSFNAIMEELGISLKNQKKLKKKSRTKGKS 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	106/405 (26%)
		ANF_receptor	51..382	CDD:279440	99/367 (27%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	184/373 (49%)
		Lig_chan	551..824	CDD:278489	138/273 (51%)
Grik1	XP_006522977.1	PBP1_iGluR_Kainate	38..431	CDD:380605	111/432 (26%)
Grik1	XP_006522977.1	Periplasmic_Binding_Protein_Type_2	446..815	CDD:389745	184/373 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846388
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.660