DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIIE and Grid2

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_032193.1	Gene:	Grid2 / 14804	MGIID:	95813	Length:	1007	Species:	Mus musculus

Alignment Length:	969	Identity:	240/969 - (24%)
Similarity:	431/969 - (44%)	Gaps:	167/969 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 IHISVNWAQYENFGGYDNYQSLESVPIGLLTDQNTEQMNIVFDHAIDVANQ--------EVGTSL 71
            :.:|..|::..:....|:.     :.||.:.|::.::.:.||..|:...||        ::..|:
Mouse     8 LFLSFCWSRTWDLATADSI-----IHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTEKITFSV 67

  Fly    72 TSLKEEVNYGDAYQSYGKLCRMLETGIAGVFGPSSRHTAVHLMSICDAMDIPHIYSYMSENAEG- 135
            |.    |:..:.:|:..:.|.::..||..:.......:|..|.|:.|||.|||:  ::..:..|
Mouse    68 TF----VDGNNPFQAVQEACELMNQGILALVSSIGCTSAGSLQSLADAMHIPHL--FIQRSTAGT 126

  Fly   136 -----------------FNLHPHPADLAKALYSLITEFNWTRFIFLYESAEYLNILNELTTMLGK 183
                             .::.| |..|.:.:..::||:.|.:||..|:|...:..:.|....:.:
Mouse   127 PRSGCGLTRSNRNDDYTLSVRP-PVYLNEVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQ 190

  Fly   184 SGTVITVLRYDMQLN---------------GNYKQVLRRVRKSVDNRIVVVGSSETMPEFLNQAQ 233
            .|..:.:.:.:..:|               ..|:..|||.        ::|.:..|...|:::..
Mouse   191 QGMDVALQKVENNINKMITTLFDTMRIEELNRYRDTLRRA--------ILVMNPATAKSFISEVV 247

  Fly   234 QVGIINEDYKYIIGNLDFHSFDLEE-YKYSEANITGLRLFSPEKMAVKE--------LLMKLGYP 289
            :..::..|..:||.|.:.:..|::| .:.|...:|.:|...|....:.:        :...|..|
Mouse   248 ETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSSLCDP 312

  Fly   290 TDQDEFRNGSCPITVEMALT----YDAVQL----FAQTLKNLPFKPMPQ-NCSQRTESVRDDGSS 345
            .|         |....|.::    ||.|.|    |.:.|::..:..|.. :|.::.......|.|
Mouse   313 KD---------PFAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRKNSKPWQGGRS 368

  Fly   346 FKNYMRTLRLTDRLLTGPIYF-EGNVRKGYHLDVI-----ELQPSGIVKVGTWDEDRQYRPQRLA 404
            ....::...:..  |||.:.| |.......|.:::     |....|:.|:|.|:
Mouse   369 MLETIKKGGVNG--LTGDLEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWN----------- 420

  Fly   405 PTTAQFDSV-DNSLANK---TFIILLSVPNKPYAQLVETYKQLEGNSQYEGYGVDLIKELADKLG 465
            |.|....|: |..|.|.   ..:.:::|..:|:..:.|..  |....:|:|:.:|::..|::.||
Mouse   421 PVTGLNGSLTDKKLENNMRGVVLRVVTVLEEPFVMVSENV--LGKPKKYQGFSIDVLDALSNYLG 483

  Fly   466 FNF-TFVNGGNDYGSYNKSTNESTGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAI 529
            ||: .:|...:.||| .:......|::.|::..|||:.|:.||||.:||..:|||..:|:..:.:
Mouse   484 FNYEIYVAPDHKYGS-PQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGV 547

  Fly   530 LYLKPQKATPELFTFMDPFSEEVWWFLGFSFLGVSLSFFILGRLSPSEWDNPYPCIEEPEELENQ 594
            |..:.:| |.::|..:.||...:|..:..:.|.|.|..::|      .|.|| |.::.......
Mouse   548 LLRRAEK-TVDMFACLAPFDLSLWACIAGTVLLVGLLVYLL------NWLNP-PRLQMGSMTST- 603

  Fly   595 FTLGNSIWFTTGALLQQGSEIGPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINS 659
             ||.||:||..|:.:|||.|:....|:||.:...||.|.|||:|||||||||||||.:.:|.|.|
Mouse   604 -TLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQS 667

  Fly   660 VDDLADNKDGVVYGAKKTGSTRNFFMTSA---EERYKKMNKFMSE----------NPQYLTEDNM 711
            :.||:...| :.||.         .:.||   ..|.|.:|.|..:          |....:|:|:
Mouse   668 LQDLSKQTD-IPYGT---------VLDSAVYQHVRMKGLNPFERDSMYSQMWRMINRSNGSENNV 722

  Fly   712 ----EGVNRVKTNTHYAFLMESTSIEY--NTKRECNLKKIGDALDEKGYGIAMRKDWPHRGKFNN 770
                .|:.:||.. :|||:.::..:||  ....:|:...:|:.:.::|||||::...|:|..|:.
Mouse   723 LESQAGIQKVKYG-NYAFVWDAAVLEYVAINDPDCSFYTVGNTVADRGYGIALQHGSPYRDVFSQ 786

  Fly   771 ALLELQEQGVLEKMKNKWWNEVGTGICATKEDAPD-ATPLDMNNLEGVFFVLLVGSCCALLYGII 834
            .:||||:.|.::.:|:|||.:.|.....:..||.. ...||:.:|.|||.:|..|...:.|..::
Mouse   787 RILELQQSGDMDILKHKWWPKNGQCDLYSSVDAKQKGGALDIKSLAGVFCILAAGIVLSCLIAVL 851

  Fly   835 -SWVLFVMKKAHHYRVPLRDALKEEFQFVIDFNNYVRVLKNSASIYSRSRQSSMSVASV 892
             :|    ..:....|||.::..||     ||..:..|.: ||......|.....|.:|:
Mouse   852 ETW----WSRRKGSRVPSKEDDKE-----IDLEHLHRRV-NSLCTDDDSPHKQFSTSSI 900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	80/418 (19%)
		ANF_receptor	51..382	CDD:279440	74/395 (19%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	124/393 (32%)
		Lig_chan	551..824	CDD:278489	96/292 (33%)
Grid2	NP_032193.1	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250\|UniProtKB:O43424	24..345		67/349 (19%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:385651	83/437 (19%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	123/389 (32%)
		Interaction with AP4M1. /evidence=ECO:0000250\|UniProtKB:Q63226	921..991
		PDZ-binding	1005..1007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846382
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740