DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and Gria4

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	XP_006509904.1	Gene:	Gria4 / 14802	MGIID:	95811	Length:	912	Species:	Mus musculus

Alignment Length:	832	Identity:	291/832 - (34%)
Similarity:	447/832 - (53%)	Gaps:	54/832 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SVPIGLLTDQNTEQMNIVFDHAIDVAN-----QEVGTSLTSLKEEVNYGDAYQSYGKLCRMLETG 97
            ||.||.|..:||:|....|..||.:.|     .|...:|....:.:...:::......|.....|
Mouse    26 SVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVDNIETANSFAVTNAFCSQYSRG 90

  Fly    98 IAGVFGPSSRHTAVHLMSICDAMDIPHIY-SYMSENAEGFNLHPHPADLAKALYSLITEFNWTRF 161
            :..:||...:.:...|.|.|.|:.|..|. |:.:|....|.|...|: |..||.||:..:.|..|
Mouse    91 VFAIFGLYDKRSVHTLTSFCSALHISLITPSFPTEGESQFVLQLRPS-LRGALLSLLDHYEWNCF 154

  Fly   162 IFLYESAEYLNILNELTTMLGKSGTVITVLRYDMQLNGNYKQVLRRVRKSVDNRIVVVGSSETMP 226
            :|||::....:||..:....|::|..::.:..:...:.:|:|:|..:.:..:.:.|:....|.:.
Mouse   155 VFLYDTDRGYSILQAIMEKAGQNGWHVSAICVENFNDVSYRQLLEELDRRQEKKFVIDCEIERLQ 219

  Fly   227 EFLNQAQQVGIINEDYKYIIGNLDFHSFDLEEYKYSEANITGLRLFSPEKMAVKELL---MKLGY 288
            ..|.|...||...:.|.|||.||.|....||.:.:..||:||.:|.......|.:|:   .||
Mouse   220 NILEQIVSVGKHVKGYHYIIANLGFKDISLERFIHGGANVTGFQLVDFNTPMVTKLMDRWKKL-- 282

  Fly   289 PTDQDEFRNGSCPITVEMALTYDAVQLFAQTLKNLPFKPM-------PQNCSQRTESVRDDGSSF 346
              ||.|:.....|.....|||||.|.:.|:|.::|..:.:       ..:|.....:....|...
Mouse   283 --DQREYPGSETPPKYTSALTYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDM 345

  Fly   347 KNYMRTLRLTDRLLTGPIYFEGNVRK-GYHLDVIELQPSGIVKVGTW-DEDRQYRPQRLAPTTAQ 409
            :..::.:|:..  |||.:.|:...|: .|.:||.||:.:|..|||.| |.|:....|. |||...
Mouse   346 ERTLKQVRIQG--LTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQD-APTLGN 407

  Fly   410 FDSVDNSLANKTFIILLSVPNKPYAQLVETYKQLEGNSQYEGYGVDLIKELADKLG--FNFTFVN 472
             |:.  ::.|:| :::.::...||....:.::..|||.:||||.|||..|:|..:|  :....|.
Mouse   408 -DTA--AIENRT-VVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVP 468

  Fly   473 GGNDYGSYNKSTNESTGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKA 537
            .|. ||:.:..|....||:.|::.|:|::||..||||..||:.:||:.|||:|||:|:..||||:
Mouse   469 DGK-YGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKS 532

  Fly   538 TPELFTFMDPFSEEVWWFLGFSFLGVSLSFFILGRLSPSEWDNPYPCIEEPEELE--------NQ 594
            .|.:|:|:||.:.|:|..:.|:::|||:..|::.|.||.||..     ||||:.:        |:
Mouse   533 KPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHT-----EEPEDGKEGPSDQPPNE 592

  Fly   595 FTLGNSIWFTTGALLQQGSEIGPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINS 659
            |.:.||:||:.||.:|||.:|.|::||.|.|...|||||||::||||||||||||:|:..|.|.|
Mouse   593 FGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIES 657

  Fly   660 VDDLADNKDGVVYGAKKTGSTRNFFMTSAEERYKKMNKFM-SENPQYLTEDNMEGVNRV-KTNTH 722
            .:|||...: :.||...:|||:.||..|....|:||..:| |..|...|....|||.|| |:...
Mouse   658 AEDLAKQTE-IAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGK 721

  Fly   723 YAFLMESTSIEYNTKRE-CNLKKIGDALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKN 786
            :|||:|||..||..:|: |:..|:|..||.||||:|..|....|...|.|:|:|.|.|||:|:||
Mouse   722 FAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAGVLDKLKN 786

  Fly   787 KWWNEVGTGICATKED-APDAT-PLDMNNLEGVFFVLLVGSCCALLYGIISW 836
            |||.:.|.  |..|:. :.|.| .|.::|:.|||::|:.|...|:|..:|.:
Mouse   787 KWWYDKGE--CGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEF 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	99/371 (27%)
		ANF_receptor	51..382	CDD:279440	88/347 (25%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	167/383 (44%)
		Lig_chan	551..824	CDD:278489	126/285 (44%)
Gria4	XP_006509904.1	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	101/378 (27%)
Gria4	XP_006509904.1	PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	169/390 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846394
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.750