DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIIE and Gria2

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_001344853.2	Gene:	Gria2 / 14800	MGIID:	95809	Length:	901	Species:	Mus musculus

Alignment Length:	900	Identity:	283/900 - (31%)
Similarity:	461/900 - (51%)	Gaps:	95/900 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ILWSLFSIHISVNWAQYENFGGYDNYQSLESVPIGLLTDQNTEQMNIVFDHAIDVANQEVGTS-- 70
            :||.|.             ||...|     |:.||.|..:..:|....|    .|...:..||
Mouse    14 VLWGLI-------------FGVSSN-----SIQIGGLFPRGADQEYSAF----RVGMVQFSTSEF 56

  Fly    71 -LTSLKEEVNYGDAYQSYGKLCRMLETGIAGVFGPSSRHTAVHLMSICDAMDIPHIY-SYMSENA 133
             ||...:.:...:::......|.....|:..:||...:.:...:.|.|..:.:..|. |:.::..
Mouse    57 RLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGT 121

  Fly   134 EGFNLHPHPADLAKALYSLITEFNWTRFIFLYESAEYLNILNELTTMLGKSGTVITVLRYDMQLN 198
            ..|.:...| ||..||.|||..:.|.:|.:||:|...|:.|..:.....:....:|.:... .:|
Mouse   122 HPFVIQMRP-DLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVG-NIN 184

  Fly   199 GN-----YKQVLRRVRKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIGNLDFHSFDLEE 258
            .:     |:.:.:.:....:.|:::....:.:.:.::|...:|...:.|.|||.||.|...||.:
Mouse   185 NDKKDETYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLK 249

  Fly   259 YKYSEANITGLRLFSPEKMAVKELLMKLGYPTDQDEFRNGSCPITVE--MALTYDAVQLFAQTLK 321
            .::..||::|.::...:...|.:.:.:  :.|.:::...|:...|::  .||||||||:..:..:
Mouse   250 IQFGGANVSGFQIVDYDDSLVSKFIER--WSTLEEKEYPGAHTATIKYTSALTYDAVQVMTEAFR 312

  Fly   322 NLPFKPMPQNCSQRTESVR---------------DDGSSFKNYMRTLRLTDRLLTGPIYFEGNVR 371
            ||.        .||.|..|               ..|...:..::.:::..  |:|.|.|:.|.:
Mouse   313 NLR--------KQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEG--LSGNIKFDQNGK 367

  Fly   372 K-GYHLDVIELQPSGIVKVGTWDEDRQYRPQRLAPTTAQFDSVDNS--LANKTFIILLSVPNKPY 433
            : .|.::::||:.:|..|:|.|.|     ..::..|..:..|.:::  |.||| :::.::...||
Mouse   368 RINYTINIMELKTNGPRKIGYWSE-----VDKMVVTLTELPSGNDTSGLENKT-VVVTTILESPY 426

  Fly   434 AQLVETYKQLEGNSQYEGYGVDLIKELADKLGFNF--TFVNGGNDYGSYNKSTNESTGMLREIMT 496
            ..:.:.::.||||.:||||.|||..|:|...||.:  |.|..|. ||:.:..|....||:.|::.
Mouse   427 VMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGK-YGARDADTKIWNGMVGELVY 490

  Fly   497 GRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLGFSFL 561
            |:||:||..||||..||:.:||:.|||:|||:|:..||||:.|.:|:|:||.:.|:|..:.|:::
Mouse   491 GKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYI 555

  Fly   562 GVSLSFFILGRLSPSEWDNPYPCIEEPE--------ELENQFTLGNSIWFTTGALLQQGSEIGPK 618
            |||:..|::.|.||.||..     ||.|        |..|:|.:.||:||:.||.:|||.:|.|:
Mouse   556 GVSVVLFLVSRFSPYEWHT-----EEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPR 615

  Fly   619 ALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVYGAKKTGSTRNF 683
            :||.|.|...|||||||::||||||||||||:|:..|.|.|.:||:...: :.||...:|||:.|
Mouse   616 SLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTE-IAYGTLDSGSTKEF 679

  Fly   684 FMTSAEERYKKMNKFM-SENPQYLTEDNMEGVNRV-KTNTHYAFLMESTSIEYNTKRE-CNLKKI 745
            |..|....:.||..:| |..|........|||.|| |:...||:|:|||..||..:|: |:..|:
Mouse   680 FRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKV 744

  Fly   746 GDALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTGICATKEDA--PDATP 808
            |..||.||||||..|....|...|.|:|:|.|||||:|:|||||.:.|.  |..|:..  ...:.
Mouse   745 GGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGE--CGAKDSGSKEKTSA 807

  Fly   809 LDMNNLEGVFFVLLVGSCCALLYGIISWVLFVMKKAHHYRVPLRDALKEEFQFVI 863
            |.::|:.|||::|:.|...|:|..:|.:......:|...::.|..|.:.:.:..|
Mouse   808 LSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKMTLSAATRNKARLSI 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	83/380 (22%)
		ANF_receptor	51..382	CDD:279440	75/357 (21%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	171/383 (45%)
		Lig_chan	551..824	CDD:278489	123/285 (43%)
Gria2	NP_001344853.2	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	84/392 (21%)
Gria2	NP_001344853.2	PBP2_iGluR_AMPA	413..794	CDD:270433	173/390 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846409
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.750