Protein Alignment GluRIIE and Gria1

DIOPT Version :10

• Sequence 1: NP_001036733.1
• Gene: GluRIIE / 318623
• FlyBaseID: FBgn0051201
• Length: 897
• Species: Drosophila melanogaster
• Sequence 2: NP_032191.2
• Gene: Gria1 / 14799
• MGIID: 95808
• Length: 907
• Species: Mus musculus
• Alignment Length: 861
• Identity: 291/861 - (33%)
• Similarity: 444/861 - (51%)
• Gaps: 90/861 - (10%)

  Fly    17 ISVNWAQYENFGG-YDNYQSLESVPIGLLTDQNTEQMNIVFDHAIDVANQEVGTSLTSLKEEVNY 80
            :..|:......|| :.|.||.|.........|.||...::  ..||:               ||.
Mouse    17 VGANFPNNIQIGGLFPNQQSQEHAAFRFALSQLTEPPKLL--PQIDI---------------VNI 64

  Fly    81 GDAYQSYGKLCRMLETGIAGVFGPSSRHTAVHLMSICDAMDIPHIY-SYMSENAEGFNLHPHPAD 144
            .|:::...:.|.....|:..:||...|.|...|.|.|.|:.:..|. |:..:.:..|.|...| :
Mouse    65 SDSFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTSNQFVLQLRP-E 128

  Fly   145 LAKALYSLITEFNWTRFIFLYESAEYLNILNELTTMLGKSGTVITVLRYDMQLNGNYKQVLRRVR 209
            |.:||.|:|..:.|..|:::|::...|::|..:.....:....:|.:.........|:.:.:.:.
Mouse   129 LQEALISIIDHYKWQTFVYIYDADRGLSVLQRVLDTAAEKNWQVTAVNILTTTEEGYRMLFQDLE 193

  Fly   210 KSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIGNLDFHSFDLEEYKYSEANITGLRLFSP 274
            |..:..:||...||.:...|.|..::......|.||:.||.|...||.::|.|.||:||.:|.:.
Mouse   194 KKKERLVVVDCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVNY 258

  Fly   275 EKMAVKELLMKLGYPTDQDEFRNGSCPITVEMALTYDAVQLFAQTLKNL---------------- 323
            .......::.:......:|..|..........|||||.|::.|:..::|
Mouse   259 TDTIPARIMQQWRTSDARDHTRVDWKRPKYTSALTYDGVKVMAEAFQSLRRQRIDISRRGNAGDC 323

  Fly   324 ---PFKPMPQNCS-QRT-ESVRDDGSSFKNYMRTLRLTDRLLTGPIYF-EGNVRKGYHLDVIELQ 382
               |..|..|... ||. :.||.:|                |||.:.| |...|..|.|.|||::
Mouse   324 LANPAVPWGQGIDIQRALQQVRFEG----------------LTGNVQFNEKGRRTNYTLHVIEMK 372

  Fly   383 PSGIVKVGTWDEDRQYRPQRLAPTTAQFDSVDNSLANKTFIILLSVPNKPYAQLVETYKQLEGNS 447
            ..||.|:|.|:||.::.|   |.|.||....::|:.|:|:|: .::...||..|.:...|.|||.
Mouse   373 HDGIRKIGYWNEDDKFVP---AATDAQAGGDNSSVQNRTYIV-TTILEDPYVMLKKNANQFEGND 433

  Fly   448 QYEGYGVDLIKELADKLGFNF--TFVNGGNDYGSYNKSTNESTGMLREIMTGRADLAITDLTITS 510
            :||||.|:|..|:|..:|:::  ..|:.|. ||:.:..|....||:.|::.||||:|:..||||.
Mouse   434 RYEGYCVELAAEIAKHVGYSYRLEIVSDGK-YGARDPDTKAWNGMVGELVYGRADVAVAPLTITL 497

  Fly   511 EREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLGFSFLGVSLSFFILGRLSP 575
            .||:.:||:.|||:|||:|:..||||:.|.:|:|:||.:.|:|..:.|:::|||:..|::.|.||
Mouse   498 VREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSP 562

  Fly   576 SEWDNPYPCIEEPEE--------LENQFTLGNSIWFTTGALLQQGSEIGPKALSTRTVASFWWFF 632
            .||.:     ||.||        ..|:|.:.||:||:.||.:|||.:|.|::||.|.|...||||
Mouse   563 YEWHS-----EEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFF 622

  Fly   633 TLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVYGAKKTGSTRNFFMTSAEERYKKMNK 697
            |||::||||||||||||:|:..|.|.|.:|||...: :.||..:.|||:.||..|....::||..
Mouse   623 TLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTE-IAYGTLEAGSTKEFFRRSKIAVFEKMWT 686

  Fly   698 FM-SENPQYLTEDNMEGVNRV-KTNTHYAFLMESTSIEYNTKRE-CNLKKIGDALDEKGYGIAMR 759
            :| |..|........||:.|| |:...||:|:|||..||..:|: |:..|:|..||.||||||..
Mouse   687 YMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATP 751

  Fly   760 KDWPHRGKFNNALLELQEQGVLEKMKNKWW---NEVGTGICATKEDAPDAT-PLDMNNLEGVFFV 820
            |....|...|.|:|:|.|||:|:|:|||||   .|.|:|    ..|:.|.| .|.::|:.|||::
Mouse   752 KGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKGECGSG----GGDSKDKTSALSLSNVAGVFYI 812

  Fly   821 LLVGSCCALLYGIISW 836
            |:.|...|:|..:|.:
Mouse   813 LIGGLGLAMLVALIEF 828

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	40..402	CDD:380605	94/384 (24%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	169/386 (44%)
		Lig_chan	551..824	CDD:459656	125/287 (44%)
Gria1	NP_032191.2	PBP1_iGluR_AMPA_GluR1	26..392	CDD:380613	100/402 (25%)
		PBP2_iGluR_AMPA_GluR1	406..787	CDD:270447	169/388 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	857..881
		PDZ-binding	904..907