Protein Alignment GluRIIE and GRIN3B

DIOPT Version :9

• Sequence 1: NP_001036733.1
• Gene: GluRIIE / 318623
• FlyBaseID: FBgn0051201
• Length: 897
• Species: Drosophila melanogaster
• Sequence 2: NP_619635.1
• Gene: GRIN3B / 116444
• HGNCID: 16768
• Length: 1043
• Species: Homo sapiens
• Alignment Length: 601
• Identity: 144/601 - (23%)
• Similarity: 236/601 - (39%)
• Gaps: 121/601 - (20%)

  Fly   307 ALTYDAVQLFAQTLKNL-------PFKPMPQNCSQ-RTESVRDDGSSFKNYMRTLRLTDRLLTGP 363
            |..:|.|||.|:.|.:.       ...|.|.||.. :.......|.....::.......|  |||
Human   291 AAIHDIVQLVARALGSAAQVQPKRALLPAPVNCGDLQPAGPESPGRFLARFLANTSFQGR--TGP 353

  Fly   364 IYFEGN--VRKGYHLDVIELQ--PSGI---VKVGTW----------------------------- 392
            ::..|:  |....|..|..|:  |.|.   ..||:|
Human   354 VWVTGSSQVHMSRHFKVWSLRRDPRGAPAWATVGSWRDGQLDLEPGGASARPPPPQGAQVWPKLR 418

  Fly   393 ---------------DEDRQYRPQRLA--PTT---AQFDSVDNSLANKTFIILLSVPNKPYAQLV 437
                           |||.|....:|.  |.|   |..|::..:|||         .:.|.|...
Human   419 VVTLLEHPFVFARDPDEDGQCPAGQLCLDPGTNDSATLDALFAALAN---------GSAPRALRK 474

  Fly   438 ETYKQLEGNSQYEGYGVDLIKELADKLGFNF-TFVNGGNDYGSYNKSTNESTGMLREIMTGRADL 501
            ..|          ||.:||::.||:...|:| .::.|...||:..  ....||::.:::.|||.:
Human   475 CCY----------GYCIDLLERLAEDTPFDFELYLVGDGKYGALR--DGRWTGLVGDLLAGRAHM 527

  Fly   502 AITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLG-FSFLGVSL 565
            |:|..:|.|.|.|.:|||.||.:..:.|:......|:| :..||.|.....|  || |:.|.::.
Human   528 AVTSFSINSARSQVVDFTSPFFSTSLGIMVRARDTASP-IGAFMWPLHWSTW--LGVFAALHLTA 589

  Fly   566 SFFILGRLSPSEWDNPYPCIEEPEELENQFTLGNSIWFTTGALLQQG-SEIGPKALSTRTVASFW 629
            .|     |:..||.:||............|:..:::......|.::. |...||..:.|.:.:.|
Human   590 LF-----LTVYEWRSPYGLTPRGRNRSTVFSYSSALNLCYAILFRRTVSSKTPKCPTGRLLMNLW 649

  Fly   630 WFFTLIVVSSYTANLAAFLTIEKPQSLINSVDD--LADNKDGVVYGAKKTGSTRNFFMTSAEERY 692
            ..|.|:|:|||||||||.:..:|....::.:.|  |.....|..:|.....|...:...|..:.:
Human   650 AIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWESSAEAYIKKSFPDMH 714

  Fly   693 KKMNKFMS-ENPQ---YLTEDNMEGVNRVKTNTHYAFLMESTSIEYNTK--RECNLKKIGDALDE 751
            ..|.:..: ..|:   .||.|      ..|.|   ||:|:.:.::|...  .:|.|..:|.....
Human   715 AHMRRHSAPTTPRGVAMLTSD------PPKLN---AFIMDKSLLDYEVSIDADCKLLTVGKPFAI 770

  Fly   752 KGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEV--GTGICATKEDAPDATPLDMNNL 814
            :||||.:.::.|.....:..:...:..|.::.:.:||:..|  |..:.|..|    ...:.:.:.
Human   771 EGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVFAVTE----TLQMSIYHF 831

  Fly   815 EGVFFVLLVGSCCALL 830
            .|:|.:|.:|...|||
Human   832 AGLFVLLCLGLGSALL 847

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	28/147 (19%)
		ANF_receptor	51..382	CDD:279440	20/84 (24%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	96/381 (25%)
		Lig_chan	551..824	CDD:278489	66/284 (23%)
GRIN3B	NP_619635.1	PBP1_iGluR_NMDA_NR3	19..405	CDD:107372	26/115 (23%)
		PBP2_iGluR_NMDA_Nr3	415..808	CDD:270438	106/430 (25%)
		Lig_chan	576..842	CDD:278489	66/285 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155967
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740