DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and GRIN3A

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_597702.2	Gene:	GRIN3A / 116443	HGNCID:	16767	Length:	1115	Species:	Homo sapiens

Alignment Length:	844	Identity:	170/844 - (20%)
Similarity:	326/844 - (38%)	Gaps:	149/844 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 DAYQSYGKLCR-MLETGIAGVFG-PSSRHTAVHLMSICDAMDIP------HIYSYMSENAEGFNL 138
            |.:.....:|. ::..|::.:.. |.|:...:.|..:...:.||      |.:...|:|.    |
Human   176 DPFSFLQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSLVLHIPVISIVRHEFPRESQNP----L 236

  Fly   139 H---------PHPADLAKALYSLITEFNWTRFIFLYESAEYLNILNELTTMLGKS----GTVITV 190
            |         ...||:.   .|::|..||..|..|....:: ||.:.|......|    |::|.:
Human   237 HLQLSLENSLSSDADVT---VSILTMNNWYNFSLLLCQEDW-NITDFLLLTQNNSKFHLGSIINI 297

  Fly   191 ---LRYDMQLNGNYKQVLRRVRKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIGNLDFH 252
               |.....|....:..|..::.|....::.....|::........|.|::..:.::::|:
Human   298 TANLPSTQDLLSFLQIQLESIKNSTPTVVMFGCDMESIRRIFEITTQFGVMPPELRWVLGD---- 358

  Fly   253 SFDLEEYKYSEANITGLRLFSPEKMAVKELLMKLGYPTDQDEFRNGSCPITVEMALTYDAVQLFA 317
            |.::||.: :|....||                         ..:|....:|......||::|.|
Human   359 SQNVEELR-TEGLPLGL-------------------------IAHGKTTQSVFEHYVQDAMELVA 397

  Fly   318 QTL-------KNLPFKPMPQNCSQRTESVRDDGSSFKNYMRTLRLTDRLLTGPIYFEGNV----R 371
            :.:       ..|...|...||.:...:....|.....::  ...|.|.|:|.|..:|:.    .
Human   398 RAVATATMIQPELALIPSTMNCMEVETTNLTSGQYLSRFL--ANTTFRGLSGSIRVKGSTIVSSE 460

  Fly   372 KGYHLDVIELQPSG---------------IVKVGTWDEDRQ-YRPQRLAPTTAQFDSVDNSLANK 420
            ..:.:..::..|.|               ::..|.|.|..| ::.....|:......|  :|...
Human   461 NNFFIWNLQHDPMGKPMWTRLGSWQGGKIVMDYGIWPEQAQRHKTHFQHPSKLHLRVV--TLIEH 523

  Fly   421 TFIILLSVPNK---PYAQLV------------ETYKQLEGNSQ----------YEGYGVDLIKEL 460
            .|:....|.::   |..||.            ..:..|..::.          | ||.:||::::
Human   524 PFVFTREVDDEGLCPAGQLCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCY-GYCIDLLEKI 587

  Fly   461 ADKLGFNF-TFVNGGNDYGSYNKSTNESTGMLREIMTGRADLAITDLTITSEREQALDFTIPFMN 524
            |:.:.|:| .::.|...||::  .....||::.:::.|.|.:|:|..:|.:.|.|.:|||.||.:
Human   588 AEDMNFDFDLYIVGDGKYGAW--KNGHWTGLVGDLLRGTAHMAVTSFSINTARSQVIDFTSPFFS 650

  Fly   525 LGIAILYLKPQKATPELFTFMDPFSEEVWWFLG-FSFLGVSLSFFILGRLSPSEWDNPYPCIEEP 588
            ..:.||......|.| :..||.|....:|  || |..|.::..|..|     .||.:|:....:.
Human   651 TSLGILVRTRDTAAP-IGAFMWPLHWTMW--LGIFVALHITAVFLTL-----YEWKSPFGLTPKG 707

  Fly   589 EELENQFTLGNSIWFTTGALLQQGSEI-GPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEK 652
            ......|:..:::......|..:...| .||..:.|.:.:.|..|.:..:|:|||||||.:..||
Human   708 RNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEK 772

  Fly   653 PQSLINSVDD--LADNKDGVVYGAKKTGSTRNFFMTSAEERYKKMNKFMSENPQYLTEDNMEGVN 715
            ....::.:.|  |.....|..:|..:..|..::...|..|.::.|.:       |......:||.
Human   773 IYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRR-------YNVPATPDGVE 830

  Fly   716 RVKTNTHY--AFLMESTSIEYNTK--RECNLKKIGDALDEKGYGIAMRKDWPHRGKFNNALLELQ 776
            .:|.:...  ||:|:...::|...  .:|.|..:|.....:||||.:..:.|.....:..:.:.:
Human   831 YLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYK 895

  Fly   777 EQGVLEKMKNKWWNEVGTGICATKEDAPDAT-PLDMNNLEGVFFVLLVGSCCALLYGIISWVLF 839
            ..|.::.:.:||:..|.   |..:..|...| .:.:.:..|:|.:|.:|...::|..|...:::
Human   896 SHGFMDMLHDKWYRVVP---CGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVY 956

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	63/363 (17%)
		ANF_receptor	51..382	CDD:279440	58/334 (17%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	93/404 (23%)
		Lig_chan	551..824	CDD:278489	62/281 (22%)
GRIN3A	NP_597702.2	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	61/360 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	59..118
		ANF_receptor	127..469	CDD:279440	58/332 (17%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	94/415 (23%)
		Lig_chan	676..942	CDD:278489	62/282 (22%)
		PPP2CB binding site. /evidence=ECO:0000250	951..987		0/6 (0%)
		GIT1-binding. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	1062..1095
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155952
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740