DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and grik3

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	XP_031752773.1	Gene:	grik3 / 100498426	XenbaseID:	XB-GENE-6050069	Length:	919	Species:	Xenopus tropicalis

Alignment Length:	911	Identity:	306/911 - (33%)
Similarity:	488/911 - (53%)	Gaps:	76/911 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 WSLFSIHISVNWAQ-------YENFGGYDNYQSLESVPIGLLTDQNTEQMNIVFDHAIDVANQEV 67
            |:::..:|.  |.|       ....||.  ::.||. |.|.|.  :.|:....|..:|...|:.:
Frog    16 WAVWFCYIF--WLQSCQGMPHVIRIGGI--FEHLEG-PTGQLV--SAEEQAFRFSASIINRNRTL 73

  Fly    68 --GTSLTSLKEEVNYGDAYQSYGKLCRMLETGIAGVFGPSSRHTAVHLMSICDAMDIPHIY---- 126
              .|:||...:.:|..|::::..|.|..|..|:..:||||...::..:.|||:|:::|||.
Frog    74 LPNTTLTYDIQRINLYDSFEANRKACDQLALGVVAIFGPSHSSSSNAVQSICNALEVPHIQVRWK 138

  Fly   127 SYMSENAEGF--NLHPHPADLAKALYSLITEFNWTRFIFLYESAEYLNILNELTTMLGKSGTVIT 189
            .:..:|.:.|  ||:|..|.|:.|:..|:....|.....:|:.:..|..|.||         ::.
Frog   139 HHPLDNRDSFYVNLYPDYASLSHAILDLVQFLKWRSATVVYDDSTGLIRLQEL---------IMA 194

  Fly   190 VLRYDMQL--------NGNYKQVLRRVRKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYII 246
            ..||:::|        :.:.:.:|:.:::..:.||:...|.....:.|.||..:|::.|.|.||.
Frog   195 PARYNIRLKIRQLPPESEDARPLLKEMKRGREFRIIFDCSHTMAAQILRQAMAMGMMTEYYHYIF 259

  Fly   247 GNLDFHSFDLEEYKYSEANITGLRLFSPEKMAVKELLMKLGY------PTDQDEFRNGSCPITVE 305
            ..||.::.|||.|:||..|:||.|:.:.:...|..::.|...      |..:....:|.  :|.:
Frog   260 TTLDLYALDLEPYRYSGVNLTGFRILNVDNPYVSSIVDKWSMERHQATPKPESGLLDGI--MTTD 322

  Fly   306 MALTYDAVQLFAQTLKNLPFKPMPQNCSQ--RTESVRDDGSSFKNYMRTLRLTDRLLTGPIYFE- 367
            .|||||||.:.:...:..|  .|..|..|  |.::.| .||.|.|:::..:...  |||.|.|.
Frog   323 AALTYDAVHIVSVCYQRAP--QMTVNSLQCHRHKAWR-FGSRFMNFIKEAQWEG--LTGRIVFNK 382

  Fly   368 -GNVRKGYHLDVIELQPSGIVKVGTWDEDRQYRPQRLAPTTAQFDSVDNSLANKTFIILLSVPNK 431
             ..:|..:.||:|.|:..|:.|||||:..........|  ..:..::..||.|:| :|:.:|..:
Frog   383 TSGLRTDFDLDIISLKEDGLEKVGTWNPSDGLNITETA--RGRGPNISESLTNRT-LIVTTVLEE 444

  Fly   432 PYAQLVETYKQLEGNSQYEGYGVDLIKELADKLGFNF--TFVNGGNDYGSYNKSTNESTGMLREI 494
            ||.....:...|.|..::||:.:||:|::|:.|||::  ..|.... |||.::. .:..|:::|:
Frog   445 PYVMFKRSDTPLFGKDRFEGFCIDLLKKIAEILGFDYDIRLVEDAK-YGSQDEK-GQWNGLVKEL 507

  Fly   495 MTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLGFS 559
            :..:||||:..||||..||:.:||:.|||.|||:|||.|.....|.:|:|::|.|.::|.::..:
Frog   508 IDHKADLAVAPLTITHVREKVIDFSKPFMTLGISILYRKANGTAPSVFSFLNPLSPDIWMYILLA 572

  Fly   560 FLGVSLSFFILGRLSPSEWDNPYPCIEEPEELENQFTLGNSIWFTTGALLQQGSEIGPKALSTRT 624
            :||||...|::.|.||.||.:.:||....:.:||.|||.||.||..|||:|||||:.|||||||.
Frog   573 YLGVSCVLFVIARFSPYEWYDAHPCNPGTDVVENNFTLLNSFWFAVGALMQQGSELMPKALSTRI 637

  Fly   625 VASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVYGAKKTGSTRNFFMTSAE 689
            :...|||||||::||||||||||||:|:.:|.|:|.|||| .:..:.|||...|:|.|||..|..
Frog   638 IGGIWWFFTLIIISSYTANLAAFLTVERMESAIDSADDLA-KQTKIEYGAVVDGATMNFFKKSHI 701

  Fly   690 ERYKKMNKFMSENPQYLTEDNMEGVNRVKTNTHYAFLMESTSIEYNTKRECNLKKIGDALDEKGY 754
            ..::||..|||..|..|.:.|.||:.|| .:..||.|||||:|||.|:|.|||.:||..:|.|||
Frog   702 STFEKMWAFMSSRPSALVKSNEEGIQRV-LSADYALLMESTAIEYITQRNCNLTQIGGLIDSKGY 765

  Fly   755 GIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTGICATKEDAPDATPLDMNNLEGVFF 819
            ||......|:|.:.:.|:|:|||...:.|||.:||...|    ..:|...:|:.|.:.|:.|:|.
Frog   766 GIGTPMGSPYRDRISIAILQLQEADEIHKMKERWWRSGG----CPEEKNKEASALGIQNMGGIFI 826

  Fly   820 VLLVGSCCALLYGIISWVLFVMKKAHHYRVPLRDALKEEFQFVIDFNNYVR-------VLKNSAS 877
            ||..|...:::..:..:|..:.|.|...:......:.:|.:..:.....|:       ::|:.|.
Frog   827 VLAGGLILSVVVAMAEFVYKLRKTAEREQRSFCSTMADEIRLSLTCQRRVKHKPQPPVMVKSDAV 891

  Fly   878 I 878
            |
Frog   892 I 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	106/379 (28%)
		ANF_receptor	51..382	CDD:279440	96/356 (27%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	169/372 (45%)
		Lig_chan	551..824	CDD:278489	129/272 (47%)
grik3	XP_031752773.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.930