Protein Alignment GluRIIE and grik3

DIOPT Version :10

• Sequence 1: NP_001036733.1
• Gene: GluRIIE / 318623
• FlyBaseID: FBgn0051201
• Length: 897
• Species: Drosophila melanogaster
• Sequence 2: XP_031752773.1
• Gene: grik3 / 100498426
• XenbaseID: XB-GENE-6050069
• Length: 919
• Species: Xenopus tropicalis
• Alignment Length: 911
• Identity: 306/911 - (33%)
• Similarity: 488/911 - (53%)
• Gaps: 76/911 - (8%)

  Fly    10 WSLFSIHISVNWAQ-------YENFGGYDNYQSLESVPIGLLTDQNTEQMNIVFDHAIDVANQEV 67
            |:::..:|.  |.|       ....||.  ::.||. |.|.|.  :.|:....|..:|...|:.:
 Frog    16 WAVWFCYIF--WLQSCQGMPHVIRIGGI--FEHLEG-PTGQLV--SAEEQAFRFSASIINRNRTL 73

  Fly    68 --GTSLTSLKEEVNYGDAYQSYGKLCRMLETGIAGVFGPSSRHTAVHLMSICDAMDIPHIY---- 126
              .|:||...:.:|..|::::..|.|..|..|:..:||||...::..:.|||:|:::|||.
 Frog    74 LPNTTLTYDIQRINLYDSFEANRKACDQLALGVVAIFGPSHSSSSNAVQSICNALEVPHIQVRWK 138

  Fly   127 SYMSENAEGF--NLHPHPADLAKALYSLITEFNWTRFIFLYESAEYLNILNELTTMLGKSGTVIT 189
            .:..:|.:.|  ||:|..|.|:.|:..|:....|.....:|:.:..|..|.||         ::.
 Frog   139 HHPLDNRDSFYVNLYPDYASLSHAILDLVQFLKWRSATVVYDDSTGLIRLQEL---------IMA 194

  Fly   190 VLRYDMQL--------NGNYKQVLRRVRKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYII 246
            ..||:::|        :.:.:.:|:.:::..:.||:...|.....:.|.||..:|::.|.|.||.
 Frog   195 PARYNIRLKIRQLPPESEDARPLLKEMKRGREFRIIFDCSHTMAAQILRQAMAMGMMTEYYHYIF 259

  Fly   247 GNLDFHSFDLEEYKYSEANITGLRLFSPEKMAVKELLMKLGY------PTDQDEFRNGSCPITVE 305
            ..||.::.|||.|:||..|:||.|:.:.:...|..::.|...      |..:....:|.  :|.:
 Frog   260 TTLDLYALDLEPYRYSGVNLTGFRILNVDNPYVSSIVDKWSMERHQATPKPESGLLDGI--MTTD 322

  Fly   306 MALTYDAVQLFAQTLKNLPFKPMPQNCSQ--RTESVRDDGSSFKNYMRTLRLTDRLLTGPIYFE- 367
            .|||||||.:.:...:..|  .|..|..|  |.::.| .||.|.|:::..:...  |||.|.|.
 Frog   323 AALTYDAVHIVSVCYQRAP--QMTVNSLQCHRHKAWR-FGSRFMNFIKEAQWEG--LTGRIVFNK 382

  Fly   368 -GNVRKGYHLDVIELQPSGIVKVGTWDEDRQYRPQRLAPTTAQFDSVDNSLANKTFIILLSVPNK 431
             ..:|..:.||:|.|:..|:.|||||:..........|  ..:..::..||.|:| :|:.:|..:
 Frog   383 TSGLRTDFDLDIISLKEDGLEKVGTWNPSDGLNITETA--RGRGPNISESLTNRT-LIVTTVLEE 444

  Fly   432 PYAQLVETYKQLEGNSQYEGYGVDLIKELADKLGFNF--TFVNGGNDYGSYNKSTNESTGMLREI 494
            ||.....:...|.|..::||:.:||:|::|:.|||::  ..|.... |||.::. .:..|:::|:
 Frog   445 PYVMFKRSDTPLFGKDRFEGFCIDLLKKIAEILGFDYDIRLVEDAK-YGSQDEK-GQWNGLVKEL 507

  Fly   495 MTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLGFS 559
            :..:||||:..||||..||:.:||:.|||.|||:|||.|.....|.:|:|::|.|.::|.::..:
 Frog   508 IDHKADLAVAPLTITHVREKVIDFSKPFMTLGISILYRKANGTAPSVFSFLNPLSPDIWMYILLA 572

  Fly   560 FLGVSLSFFILGRLSPSEWDNPYPCIEEPEELENQFTLGNSIWFTTGALLQQGSEIGPKALSTRT 624
            :||||...|::.|.||.||.:.:||....:.:||.|||.||.||..|||:|||||:.|||||||.
 Frog   573 YLGVSCVLFVIARFSPYEWYDAHPCNPGTDVVENNFTLLNSFWFAVGALMQQGSELMPKALSTRI 637

  Fly   625 VASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVYGAKKTGSTRNFFMTSAE 689
            :...|||||||::||||||||||||:|:.:|.|:|.|||| .:..:.|||...|:|.|||..|..
 Frog   638 IGGIWWFFTLIIISSYTANLAAFLTVERMESAIDSADDLA-KQTKIEYGAVVDGATMNFFKKSHI 701

  Fly   690 ERYKKMNKFMSENPQYLTEDNMEGVNRVKTNTHYAFLMESTSIEYNTKRECNLKKIGDALDEKGY 754
            ..::||..|||..|..|.:.|.||:.|| .:..||.|||||:|||.|:|.|||.:||..:|.|||
 Frog   702 STFEKMWAFMSSRPSALVKSNEEGIQRV-LSADYALLMESTAIEYITQRNCNLTQIGGLIDSKGY 765

  Fly   755 GIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTGICATKEDAPDATPLDMNNLEGVFF 819
            ||......|:|.:.:.|:|:|||...:.|||.:||...|    ..:|...:|:.|.:.|:.|:|.
 Frog   766 GIGTPMGSPYRDRISIAILQLQEADEIHKMKERWWRSGG----CPEEKNKEASALGIQNMGGIFI 826

  Fly   820 VLLVGSCCALLYGIISWVLFVMKKAHHYRVPLRDALKEEFQFVIDFNNYVR-------VLKNSAS 877
            ||..|...:::..:..:|..:.|.|...:......:.:|.:..:.....|:       ::|:.|.
 Frog   827 VLAGGLILSVVVAMAEFVYKLRKTAEREQRSFCSTMADEIRLSLTCQRRVKHKPQPPVMVKSDAV 891

  Fly   878 I 878
            |
 Frog   892 I 892

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	40..402	CDD:380605	107/387 (28%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	169/372 (45%)
		Lig_chan	551..824	CDD:459656	129/272 (47%)
grik3	XP_031752773.1	PBP1_iGluR_Kainate	37..417	CDD:380605	111/400 (28%)
		Periplasmic_Binding_Protein_Type_2	433..801	CDD:473866	169/372 (45%)