DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and grik5

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	XP_002936446.1	Gene:	grik5 / 100497490	XenbaseID:	XB-GENE-953974	Length:	995	Species:	Xenopus tropicalis

Alignment Length:	892	Identity:	293/892 - (32%)
Similarity:	439/892 - (49%)	Gaps:	94/892 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LESVPIGLLTDQNT--------------EQMNIVFDHAIDVANQEVGTSLTSLKEEVNYGDAYQS 86
            |.|:.:..:.|..|              |.:|   .|....|:..|...:..|:::    ..|::
Frog    25 LSSLRVAAILDDQTVCGRGERLALALAREHIN---SHTQGSASGRVEVEIFELQKD----SQYET 82

  Fly    87 YGKLCRMLETGIAGVFGPSSRHTAVHLMS-ICDAMDIPHIYSYMSENAE-------GFNLHPHPA 143
            ...:|::|..|:..|.|||:...:...:| ||...:||||.....|..:       ..:|:|...
Frog    83 TDTMCQILPKGVVSVLGPSTSPASASTVSHICGEKEIPHIKVGPEEAPKLQYLRFASVSLYPSNE 147

  Fly   144 DLAKALYSLITEFNWTRFIFLYESAEYLNILNELTTMLGKSGTVITVLRYDMQLNGNYKQVLRRV 208
            |::.|:..::..|:......:...||.|..|.||......|...::|...|.  :.:...:|:.:
Frog   148 DISLAVSHILKSFHNPSTSLICAKAECLLRLEELVRQFLISKDTLSVRMLDE--SNDPTPLLKEI 210

  Fly   209 RKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIGNLDFHSFDLEEYKYSEANITGLRLFS 273
            |....:.|::..::......|.:|.::|:.:..||||:..:||....||.....::||.|..:::
Frog   211 RDDKVSTIIIDANATVSHLILKKASELGMTSAHYKYILTTMDFPLLSLEGIVSDQSNILGFSMYN 275

  Fly   274 PEKMAVKELLMKLGYPTDQDEFRNGSCPIT------VEMALTYDAVQLFAQTLKNLPFKPMPQNC 332
            .......|.|..|.....:      :|.::      :..||.:|||.:....::.|       |.
Frog   276 SSHPFYLEFLRSLNMSWRE------NCELSTYLGPALSAALMFDAVHVVVSAVREL-------NR 327

  Fly   333 SQR---------TESVRDDGSSFKNYMRTLRLTDRLLTGPIYFEG-NVRKGYHLDVIELQPSGIV 387
            ||.         |..:...|:|..||:|.:....  |||.:.|.. ..|..|.|.::|....|..
Frog   328 SQEIGVKQLSCSTSQIWQHGTSLMNYLRMVEYDG--LTGRVEFNSKGQRTNYTLRILEKAGDGHR 390

  Fly   388 KVGTWDEDRQYRPQRLAPTTAQFD-SVDNSLANKTFIILLSVPNKPYAQLVETYKQLEGNSQYEG 451
            ::|.|     |..:.||......| |...:|.|||.::...:.| ||......|:.|.||.||||
Frog   391 EIGVW-----YSNRTLAMNATSLDLSTSETLENKTLVVTTILEN-PYMMRKSNYRSLSGNDQYEG 449

  Fly   452 YGVDLIKELADKLGFNF--TFVNGGNDYGSYNKSTNES-TGMLREIMTGRADLAITDLTITSERE 513
            :..:::.|||..|.||:  ..|..|. ||:  ...|.| |||:.|::..:||||:...|||:|||
Frog   450 FCAEMLMELAALLRFNYKIKLVEDGL-YGA--PEPNGSWTGMVGELINRKADLAVAAFTITAERE 511

  Fly   514 QALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLGFSFLGVSLSFFILGRLSPSEW 578
            :.:||:.|||.|||:|||.......|..|:|:||||..||.|:..::|.||...|:..||||.||
Frog   512 KVIDFSKPFMTLGISILYRVQMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEW 576

  Fly   579 DNPYPCIEEPEE-LENQFTLGNSIWFTTGALLQQGSEIGPKALSTRTVASFWWFFTLIVVSSYTA 642
            .||:||:.|... ||||:|||||:||..|..:|||||:.|:|||||.|:..||.||||::|||||
Frog   577 YNPHPCLRERHHILENQYTLGNSLWFPVGGFMQQGSEVMPRALSTRCVSGVWWAFTLIIISSYTA 641

  Fly   643 NLAAFLTIEKPQSLINSVDDLADNKDGVVYGAKKTGSTRNFFMTSAEERYKKMNKFM-SENPQYL 706
            |||||||:::.:..|.|.||||| :..:.||....|||..||..|..:.|::|..:| |:.|...
Frog   642 NLAAFLTVQRMEVPIESADDLAD-QTNIEYGTIHGGSTMTFFQNSRYQTYQRMWNYMNSKQPSVF 705

  Fly   707 TEDNMEGVNRVKTNTHYAFLMESTSIEYNTKRECNLKKIGDALDEKGYGIAMRKDWPHRGKFNNA 771
            .:...||:.|| .|:.||||:|||..||:.:..|||.:||..||.|||||.|....|:|.:...|
Frog   706 VKSTEEGIARV-LNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPYRDEITLA 769

  Fly   772 LLELQEQGVLEKMKNKWWNEVGTGICATKEDAPDATPLDMNNLEGVFFVLLVGSCCALLYGIISW 836
            :|:|||...||.:|.|||.   .|.|..:|| ..|..|.|.|:.|:|.||:.|...|:...|:.:
Frog   770 ILQLQENNRLEILKRKWWE---GGKCPKEED-HRAKGLGMENIGGIFVVLICGLIIAVFVAIMEF 830

  Fly   837 VLFVMKKAHHYRVPLRDALKEEFQFVIDFNNYVRVLKNSASIYSRSR 883
            |....:...:..:.:...:..|.:..:           |....||||
Frog   831 VWSTRRSVDNEEISVCQEMLSELRSAV-----------SCKKTSRSR 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	85/391 (22%)
		ANF_receptor	51..382	CDD:279440	79/354 (22%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	177/375 (47%)
		Lig_chan	551..824	CDD:278489	132/274 (48%)
grik5	XP_002936446.1	PBP1_iGluR_Kainate_KA1_2	27..405	CDD:380616	89/406 (22%)
grik5	XP_002936446.1	Periplasmic_Binding_Protein_Type_2	418..788	CDD:389745	177/375 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.930