DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and grik2

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	XP_017949808.1	Gene:	grik2 / 100495093	XenbaseID:	XB-GENE-5902331	Length:	913	Species:	Xenopus tropicalis

Alignment Length:	884	Identity:	313/884 - (35%)
Similarity:	485/884 - (54%)	Gaps:	86/884 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 WAQYE-------NFGGYDNYQSLESVPIGLLTDQNTEQMNIVFDHAIDVANQE----VGTSLTSL 74
            |..|.       .|||...|  :||.|.|      .|:  :.|..|::..|:.    ..|:||..
Frog    30 WIGYTQGTTHVLRFGGIFEY--VESGPFG------AEE--LAFRFAVNTINRNRTLLPNTTLTYD 84

  Fly    75 KEEVNYGDAYQSYGKLCRMLETGIAGVFGPSSRHTAVHLMSICDAMDIPHIYS----YMSENAEG 135
            .:.:|..|::::..|.|..|..|:|.:||||...:|..:.|||:|:.:|||.:    .:|:|.:.
Frog    85 TQRINLYDSFEASRKACEQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDS 149

  Fly   136 F--NLHPHPADLAKALYSLITEFNWTRFIFLYESAEYLNILNELTTMLGKSGTVITVLRYDMQL- 197
            |  :|:|..:.|::|:..|:..|.|......|:.:..|..|.||         :....||:::|
Frog   150 FYVSLYPDFSSLSRAILDLVQFFKWKTVTIAYDDSTGLIRLQEL---------IKAPSRYNLRLK 205

  Fly   198 -------NGNYKQVLRRVRKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIGNLDFHSFD 255
                   ..:.|.:|:.:::..:..::...|.:.....|.||..:|::.|.|.||...||..:.|
Frog   206 IRQLPIDTKDAKPLLKEMKRGKEFHVIFDCSHDMAAGILKQALAMGMMTEYYHYIFTTLDLFALD 270

  Fly   256 LEEYKYSEANITGLRLFSPEKMAVKELLMK-----LGYPTDQDE-FRNGSCPITVEMALTYDAVQ 314
            :|.|:||..|:||.|:.:.|...|..::.|     |..|...|. ..:|.  :|.:.||.||||.
Frog   271 VEPYRYSGVNMTGFRILNIENSQVLSIIEKWSMERLQAPPKPDSGLLDGF--MTTDAALMYDAVH 333

  Fly   315 LFAQTLKNLPFKPMPQNCSQRTESVRDDGSSFKNYMRTLRLTDRLLTGPIYFE--GNVRKGYHLD 377
            :.:..::..|...:......|.:..| .|:.|.:.::......  |||.|.|.  ..:|..:.||
Frog   334 VVSVAVQQFPQMTVSSLQCNRHKPWR-FGARFISLIKEAHWEG--LTGRITFNKTNGLRTDFDLD 395

  Fly   378 VIELQPSGIVKVGTWD--------EDRQYRPQRLAPTTAQFDSVDNSLANKTFIILLSVPNKPYA 434
            ||.|:..|:.|:||||        |:::.:|.          ::.:||:|:: :|:.::..:||.
Frog   396 VISLKEEGLEKIGTWDPTSGLNMTENQKGKPA----------NITDSLSNRS-LIVTTILEEPYV 449

  Fly   435 QLVETYKQLEGNSQYEGYGVDLIKELADKLGFNF--TFVNGGNDYGSYNKSTNESTGMLREIMTG 497
            ...::.|.|.|.:::|||.:||:::|:..|||.:  ..|..|. ||:.:.:|.:..||:||:|..
Frog   450 MFKKSDKPLYGKARFEGYCIDLLEKLSKILGFEYEVRLVEDGK-YGAKDDTTQQWNGMVRELMDH 513

  Fly   498 RADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLGFSFLG 562
            :||||:..|.||..|||.:|||.|||.|||:|||.||....|.:|:|::|.|.::|.::..::||
Frog   514 KADLAVAPLAITYVREQVIDFTKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLG 578

  Fly   563 VSLSFFILGRLSPSEWDNPYPCIEEPEELENQFTLGNSIWFTTGALLQQGSEIGPKALSTRTVAS 627
            ||...|::.|.||.||.||:||..:.:.:||.|||.||.||..|||:|||||:.|||||||.|..
Frog   579 VSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGG 643

  Fly   628 FWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVYGAKKTGSTRNFFMTSAEERY 692
            .|||||||::||||||||||||:|:.:|.|:|.|||| .:..:.|||.:.|:|..||..|....|
Frog   644 IWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLA-KQTKIEYGAVQDGATMTFFKKSRIPTY 707

  Fly   693 KKMNKFMSENPQ-YLTEDNMEGVNRVKTNTHYAFLMESTSIEYNTKRECNLKKIGDALDEKGYGI 756
            :||..||:...| .|.::|.||:.||.| :.||||||||:||:.|:|.|||.:||..:|.||||:
Frog   708 EKMWAFMNSRSQSVLVKNNEEGIQRVLT-SDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGV 771

  Fly   757 AMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTGICATKEDAPDATPLDMNNLEGVFFVL 821
            ......|:|.|...|:|:|||:|||..||.|||.  |.|  ..:|::.:|:.|.:.|:.|:|.||
Frog   772 GTPMGSPYRDKITIAILQLQEEGVLHMMKEKWWR--GNG--CPEEESKEASALGVQNIGGIFIVL 832

  Fly   822 LVGSCCALLYGIISWVLFVMKKAHHYRVPLRDALKEEFQ 860
            ..|...::...:..::....|.|...:.....|:.||.:
Frog   833 AAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELR 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	104/387 (27%)
		ANF_receptor	51..382	CDD:279440	94/356 (26%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	180/373 (48%)
		Lig_chan	551..824	CDD:278489	136/273 (50%)
grik2	XP_017949808.1	PBP1_iGluR_Kainate	42..419	CDD:380605	110/400 (28%)
grik2	XP_017949808.1	Periplasmic_Binding_Protein_Type_2	435..805	CDD:419667	180/373 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010