DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and grik1

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	XP_004912220.1	Gene:	grik1 / 100493949	XenbaseID:	XB-GENE-957124	Length:	928	Species:	Xenopus tropicalis

Alignment Length:	927	Identity:	324/927 - (34%)
Similarity:	492/927 - (53%)	Gaps:	118/927 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 QYENFGGYDNYQSLESVPIGLLTDQNTEQMNIVFDHAIDVANQE----VGTSLTSLKEEVNYGDA 83
            |....||.  ::::|:.||      |.|:  :.|..|:...|:.    ..|:||...:.:|..|:
Frog    43 QVLRIGGI--FETVENEPI------NVEE--LAFKFAVTNINRNRTLMPNTTLTYDIQRINLFDS 97

  Fly    84 YQSYGKLCRMLETGIAGVFGPSSRHTAVHLMSICDAMDIPHIYSYMS----ENAEGF--NLHPHP 142
            :::..:.|..|..|:|.:||||...:...:.|||:|:::|||.:...    :|.:.|  ||||..
Frog    98 FEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNKDSFFINLHPDY 162

  Fly   143 ADLAKALYSLITEFNWTRFIFLYESAEYLNILNELTTMLGKSGTVITVLRYDMQL--------NG 199
            |.:::|:..|:..::|.....:||.:..|..|.||         :....||::::        |.
Frog   163 AAISRAVLELVLHYSWKTVTVVYEDSTGLIRLQEL---------IKAPSRYNIKIKIRQLPSGNK 218

  Fly   200 NYKQVLRRVRKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIGNLDFHSFDLEEYKYSEA 264
            :.:.:|:.::||.:..::...|.||..|.|.|...:|::.|.|.|....:|..:.|||.|:||..
Frog   219 DARTLLKEMKKSREFYVIFDCSHETAAEILKQILSMGMMTEYYHYFFTTMDLFALDLEPYRYSGV 283

  Fly   265 NITGLRLFSPEKMAVKELLMKLGY------PTDQDEFRNGSCPITVEMALTYDAVQLFA------ 317
            |:||.||.:.:...|..::.|...      |..:....:|.  :|.:.||.||||.:.|
Frog   284 NMTGFRLLNIDNPQVSSVVEKWSMERLQAPPKPETGLLDGM--MTTDAALMYDAVYMVAVATQRA 346

  Fly   318 --------QTLKNLPFKPMPQNCSQRTESVRDDGSSFKNYMRTLRLTDRLLTGPIYFE--GNVRK 372
                    |..::.|::..|:..|...|: |.||                |||.|.|.  ..:|:
Frog   347 TQMTVSSLQCHRHKPWRFGPRFMSLIKEA-RWDG----------------LTGRITFNRTDGLRR 394

  Fly   373 GYHLDVIELQPSGI---------------VKVGTWDEDRQYRPQRLAPTTAQFD---SVDNSLAN 419
            .:.:|:|.|:..|:               .|||.|:.:     ..|..|....|   ::.:||||
Frog   395 DFDMDIISLKEDGMEKAAGETVNHLNKVWKKVGVWNSN-----TGLNMTDNLKDKSTNITDSLAN 454

  Fly   420 KTFIILLSVPNKPYAQLVETYKQLEGNSQYEGYGVDLIKELADKLGFNF---TFVNGGNDYGSYN 481
            :| :|:.::...||....::.|.|.||.::|||.:||:|||::.|||.:   ..|:|  .||:.|
Frog   455 RT-LIVTTILEDPYVMFRKSDKPLYGNDRFEGYCLDLLKELSNILGFTYEVRLVVDG--KYGAQN 516

  Fly   482 KSTNESTGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMD 546
             ...|..||:||::..:||||:..||||..||:.:||:.|||.|||:|||.||....|.:|:|::
Frog   517 -DKGEWNGMVRELIDHKADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLN 580

  Fly   547 PFSEEVWWFLGFSFLGVSLSFFILGRLSPSEWDNPYPCIEEPEELENQFTLGNSIWFTTGALLQQ 611
            |.|.::|.::..:.||||...|::.|.:|.||.||:||..:.:.:||.|||.||.||..|||:||
Frog   581 PLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQ 645

  Fly   612 GSEIGPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVYGAKK 676
            |||:.|||||||.|...|||||||::||||||||||||:|:.:|.|:|.|||| .:..:.|||.:
Frog   646 GSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLA-KQTKIEYGAVR 709

  Fly   677 TGSTRNFFMTSAEERYKKMNKFMSENPQ-YLTEDNMEGVNRVKTNTHYAFLMESTSIEYNTKREC 740
            .|||..||..|....|:||..|||...| .|.::|.||:.||.| |.||.|||||||||.|:|.|
Frog   710 DGSTMTFFKKSKISTYEKMWAFMSSRQQTALVKNNDEGIQRVLT-TDYALLMESTSIEYVTQRNC 773

  Fly   741 NLKKIGDALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTGICATKEDAPD 805
            ||.:||..:|.||||:......|:|.|...|:|:|||:|.|..||.|||.  |.|  ..:||:.:
Frog   774 NLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWR--GNG--CPEEDSKE 834

  Fly   806 ATPLDMNNLEGVFFVLLVGSCCALLYGIISWVLFVMKKAHHYRVPLRDALKEEFQFVIDFNNYVR 870
            |:.|.:.|:.|:|.||..|...::...|..::....|.:...:....:|:.||....:   .:.:
Frog   835 ASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNSDIEQCLSFNAIMEELGISL---KHPK 896

  Fly   871 VLKNSASIYSRSRQSSM 887
            .||.......||..:||
Frog   897 RLKKKPKAKGRSSFTSM 913

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	103/408 (25%)
		ANF_receptor	51..382	CDD:279440	95/370 (26%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	185/374 (49%)
		Lig_chan	551..824	CDD:278489	139/273 (51%)
grik1	XP_004912220.1	Periplasmic_Binding_Protein_Type_1	43..438	CDD:299141	110/437 (25%)
		ANF_receptor	61..404	CDD:279440	96/372 (26%)
		Periplasmic_Binding_Protein_Type_2	454..823	CDD:304360	185/374 (49%)
		Lig_chan	585..854	CDD:278489	139/274 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010