Protein Alignment GluRIIE and grik4

DIOPT Version :10

• Sequence 1: NP_001036733.1
• Gene: GluRIIE / 318623
• FlyBaseID: FBgn0051201
• Length: 897
• Species: Drosophila melanogaster
• Sequence 2: XP_031761990.1
• Gene: grik4 / 100490768
• XenbaseID: XB-GENE-1011875
• Length: 962
• Species: Xenopus tropicalis
• Alignment Length: 878
• Identity: 290/878 - (33%)
• Similarity: 446/878 - (50%)
• Gaps: 85/878 - (9%)

  Fly    39 VPIGLLTDQNTEQMNI--VFDHAIDVANQEVGTSLTSLKEEVN-----YGDA------------- 83
            |.:.|:....:..:.|  :.|..::.:..| ..|:|..|..:|     .|.|
 Frog    11 VLLWLMKSAGSPSLRIAAILDDPMECSRGE-RLSITLAKNRINRAPERQGKARLEVDIFELLKDS 74

  Fly    84 -YQSYGKLCRMLETGIAGVFGPSSRHTAVHLMS-ICDAMDIPHI-------YSYMSENAEGFNLH 139
             |::...:|::|..|:.||.|||...::..::| ||...::|||       ..:..:.....|||
 Frog    75 EYETAETMCQILPKGVLGVLGPSYSPSSSSIISNICGEKEVPHIKVSTEEFLRFQYQRFTTLNLH 139

  Fly   140 PHPADLAKALYSLITEFNWTRFIFLYESAEYLNILNELTTMLGKSGTVITVLRYDMQLNGNYKQV 204
            |...|::.|:.:|:..||.|....:...||.|..|.:|......|...::|...|...:..  .:
 Frog   140 PSNTDISAAVATLLRFFNSTTACLICAKAECLLNLEKLLRQFLISKDCLSVRMLDDTWDPT--PL 202

  Fly   205 LRRVRKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIGNLDFHSFDLEEYKYSEANITGL 269
            |:.:|....:.|:|..::......|.:|.::|::...|.||..||:|.....|.......||.|.
 Frog   203 LKEIRDDKTSTIIVHANASMSHTILMKAAELGMVTAYYTYIFTNLEFVLQRFESPLDDRVNILGF 267

  Fly   270 RLFSPEKMAVKELLMKLGYPTDQDEFRNGSC---PIT---VEMALTYDAVQLFAQTLKNL----- 323
            .:|:......||....|....::      :|   |.|   :..||.:|||......::.|
 Frog   268 SMFNQSHSYFKEFAHTLQQSWEE------NCDHSPFTGPALSAALLFDAVYGIVSAVQELNRSQE 326

  Fly   324 -PFKPMPQNCSQRTESVRDDGSSFKNYMRTLRLTDRLLTGPIYFEG-NVRKGYHLDVIELQPSGI 386
             ..||:....||    :...|:|..||:|.:.|..  |||.:.|.. ..|..|.:.:::...:|.
 Frog   327 IGVKPLSCGSSQ----IWQHGTSLMNYLRMVELEG--LTGHVEFNSKGQRSNYDMKIMQYTKTGF 385

  Fly   387 VKVGTW------DEDRQYRPQRLAPTTAQFDSVDNSLANKTFI---ILLSVPNKPYAQLVETYKQ 442
            .::|.|      :.|::|    .:|      :..::|.|||.|   ||..:...||..|...:::
 Frog   386 QEIGQWHVTNGLNMDKRY----FSP------NASDTLVNKTLIVTTILFFLQENPYLMLKANHQE 440

  Fly   443 LEGNSQYEGYGVDLIKELADKLGFNFTFVNGGNDYGSYNKSTNESTGMLREIMTGRADLAITDLT 507
            ||||.:|||:.||::||||..|.||:......:......:.....|||:.|:::.:||||:..||
 Frog   441 LEGNDRYEGFCVDMLKELAAILRFNYKIRLVADGVYGVPELNGTWTGMVGELISRKADLAVAGLT 505

  Fly   508 ITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLGFSFLGVSLSFFILGR 572
            ||:|||:.:||:.|||.|||:|||.......|..|:|:||||..||.|:..::|.||...|::.|
 Frog   506 ITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVAR 570

  Fly   573 LSPSEWDNPYPCIE-EPEELENQFTLGNSIWFTTGALLQQGSEIGPKALSTRTVASFWWFFTLIV 636
            |:|.||.:|:||.: ....|.||::||||:||..|..:||||.|.|:|||||.|:..||.||||:
 Frog   571 LTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLII 635

  Fly   637 VSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVYGAKKTGSTRNFFMTSAEERYKKMNKFM-S 700
            :||||||||||||:::....|.||||||| :..:.||....||:..||..|..:.|::|..:| |
 Frog   636 ISSYTANLAAFLTVQRMDVPIESVDDLAD-QTTIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMHS 699

  Fly   701 ENPQYLTEDNMEGVNRVKTNTHYAFLMESTSIEYNTKRECNLKKIGDALDEKGYGIAMRKDWPHR 765
            :.|....:...||:.|| .|::||||:|||..||..:|.|||.::|..||.|||||.|......|
 Frog   700 KQPSVFVKSTEEGIARV-LNSNYAFLLESTMNEYYRQRNCNLTQVGGLLDTKGYGIGMPVGSAFR 763

  Fly   766 GKFNNALLELQEQGVLEKMKNKWWNEVGTGICATKEDAPDATPLDMNNLEGVFFVLLVGSCCALL 830
            .:|:.|:|:|||...||.:|.|||:   .|.|..:|| ..|..|.|.|:.|:|.||:.|...|:|
 Frog   764 DEFDLAILQLQENNCLEDLKRKWWD---GGKCPKEED-HRAKGLGMENIGGIFVVLICGLIVAIL 824

  Fly   831 YGIISWVLFVMKKAHHYRVPLRDALKEEFQFVI 863
            ..::.: |:.::.|....|.:...:..|...:|
 Frog   825 IAMLEF-LWTVRNAEDSEVSVCQEMASELSSII 856

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	40..402	CDD:380605	94/409 (23%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	172/375 (46%)
		Lig_chan	551..824	CDD:459656	127/274 (46%)
grik4	XP_031761990.1	Periplasmic_Binding_Protein_type1	23..400	CDD:471960	91/391 (23%)
		PBP2_iGluR_kainate_KA1	414..788	CDD:270442	172/375 (46%)