Protein Alignment GluRIIE and grin2b

DIOPT Version :9

• Sequence 1: NP_001036733.1
• Gene: GluRIIE / 318623
• FlyBaseID: FBgn0051201
• Length: 897
• Species: Drosophila melanogaster
• Sequence 2: XP_017948700.2
• Gene: grin2b / 100490580
• XenbaseID: XB-GENE-949327
• Length: 1449
• Species: Xenopus tropicalis
• Alignment Length: 947
• Identity: 216/947 - (22%)
• Similarity: 387/947 - (40%)
• Gaps: 189/947 - (19%)

  Fly    31 DNYQSLESVP-IGLLTDQNTEQMNIVFDHAIDVANQEVGTSLTSLKEE-----VNYGDAYQSYGK 89
            |::..|...| :.|:|...::..:|:             |.:..|..:     |.:||......
 Frog    52 DDFHHLPVTPRVALVTMNESDPKSII-------------TRICDLMSDKKVQGVVFGDDTDQEA- 102

  Fly    90 LCRMLE-------TGIAGVFGPSSRHTAVHLMSICDAMDIPHIYSYMSENAEGFNLHPHPADLAK 147
            :.::|:       |.|.|:.|.||       |.:.|          ..|.:..|...|.....|.
 Frog   103 IAQILDFISVQTLTPILGIHGGSS-------MIMAD----------KEEASMFFQFGPSIEQQAS 150

  Fly   148 ALYSLITEFNWTRFIFLYESA---EYLNILNELTTMLGKS---GTVITVLRYDMQLNGNYKQVLR 206
            .:.:::.|::|  :||...:.   .|.:..|::.:.:..|   ..:..|:..||.|:.|..::..
 Frog   151 VMLNIMEEYDW--YIFSIVTTYFPGYQDFENKVRSTIENSFVGWELEEVIHLDMSLDDNDSKIQN 213

  Fly   207 RVRKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIGNLDFHSFDLEEYKYSEANITGLRL 271
            :::|.....|::..:.|........|..||:....|.:|:.:|.....|....::.    |||..
 Frog   214 QLKKLQSPVILLYCTKEEATYIFEVAHSVGLTGYGYTWIVPSLVAGDTDTVPAEFP----TGLIS 274

  Fly   272 FS--------PEKMAVKELLMKLGYPTDQDEFRN-----GSCPITVEMALTYDAVQLFAQTLKNL 323
            .|        |.::.....::.....|...|..:     .|| ..::.:..|:| .:..:.|.|:
 Frog   275 VSYDEWDYDLPARVRDGIAIITTAASTMLSEHNSIPQSKSSC-YNIQESRVYEA-HMLKRYLINV 337

  Fly   324 PFKPMPQNCSQRTESVRDDG------------SSFKNYMRTLRLTDRLLTGPIY----FE----G 368
            .|:       .|..|..:||            :..:.:.|..:..||.|....|    ||    .
 Frog   338 TFE-------GRNLSFSEDGYQMHPKLVIILLNQQRKWERVGKYKDRSLKMKYYVWPVFELYPNS 395

  Fly   369 NVRKGYHLDVIELQPSGIVKVGTWDEDRQYRPQRLAPTTAQFDSVDNSLANKTFIILLSVPNKPY 433
            ...|..||.::.|:.:..|.|    ||              .|.:..:....|.         |.
 Frog   396 EEHKDEHLSIVTLEEAPFVIV----ED--------------VDPLSGTCMRNTV---------PC 433

  Fly   434 AQLVETYKQLEGNSQY-----EGYGVDLIKELADKLGFNFTFVNGGNDYGSYNKSTNES-TGMLR 492
            .:.:.|..:.|....|     :|:.:|::|::|..:.|.:......|  |.:.|..|.: .||:.
 Frog   434 RKQIRTENRTEEGGNYIKRCCKGFCIDILKKIAKTVKFTYDLYLVTN--GKHGKKINGTWNGMIG 496

  Fly   493 EIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLG 557
            |::|.||.:|:..|||..||.:.:||::||:..||::: :.....|.....|::|||.:||..:.
 Frog   497 EVVTKRAYMAVGSLTINEERSEVVDFSVPFIETGISVM-VSRSNGTVSPSAFLEPFSADVWVMMF 560

  Fly   558 FSFLGVS-LSFFILGRLSPSEWDNPYPCIEEPEELEN-QFTLGNSIWFTTGALLQQGSEI-GPKA 619
            ...|.|| ::.|:....||..::.   |:.:..|... .||:|.:||...|.:......: .||.
 Frog   561 VMLLIVSAVAVFVFEYFSPVGYNR---CLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKG 622

  Fly   620 LSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNK--------DGVVYGAKK 676
            .:::.:.|.|.||.:|.::|||||||||:..|:   .::.|..|:|.|        ....:|...
 Frog   623 TTSKIMVSVWAFFAVIFLASYTANLAAFMIQEE---YVDQVSGLSDKKFQRPNDFSPAFRFGTVP 684

  Fly   677 TGST-RNFFMTSAEERYKKMNKFMSENPQYLTEDNMEGVNRVKTNTHYAFLMESTSIEYNTKRE- 739
            .||| ||.     ...|.:|:.:|.:..|...:|   .:..:||....||:.::..:.|...|:
 Frog   685 NGSTERNI-----RNNYLEMHSYMVKFNQRSVQD---ALLSLKTGKLDAFIYDAAVLNYMAGRDE 741

  Fly   740 -CNLKKIGD--ALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTGICATKE 801
             |.|..||.  .....|||||::||...:.:.:.|:|:|...|.:|:::..|.    ||||..::
 Frog   742 GCKLVTIGSGKVFATTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWL----TGICHNEK 802

  Fly   802 DAPDATPLDMNNLEGVFFVLLVGSCCALLYGIISWVLFVMKKAHHYRVPLRDALKEEFQFVIDFN 866
            :...::.||::|:.|||::|.....       :|.:.|:|:....::      |:..|..|....
 Frog   803 NEVMSSQLDIDNMAGVFYMLAAAMA-------LSLITFIMEHLFFWQ------LRHCFMGVCSGK 854

  Fly   867 NYVRVLKNSASIYS-------RSRQSSMSVASVAQES 896
            ..| |...|..|||       ..|||:|:..|....:
 Frog   855 PGV-VFSISRGIYSCIHGVPIEDRQSAMNSPSATMNN 890

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	75/404 (19%)
		ANF_receptor	51..382	CDD:279440	69/381 (18%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	108/392 (28%)
		Lig_chan	551..824	CDD:278489	82/288 (28%)
grin2b	XP_017948700.2	PBP1_iGluR_NMDA_NR2	28..383	CDD:380601	68/376 (18%)
		PBP2_iGluR_NMDA_Nr2	400..800	CDD:270436	120/447 (27%)
		NMDAR2_C	837..1449	CDD:402274	14/61 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910