DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and grin2cb

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	XP_009305071.2	Gene:	grin2cb / 100333648	ZFINID:	ZDB-GENE-100308-2	Length:	1328	Species:	Danio rerio

Alignment Length:	859	Identity:	198/859 - (23%)
Similarity:	360/859 - (41%)	Gaps:	173/859 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 IAGVFGPSSRHTAVHLMSIC--DAMDIPHIYSYMSENAEGFNLHPHPADL---AKALYSLITEFN 157
            :|.:....|..|::.::.|.  .|:.|||       .|:|.......|.:   ..|::.::.|:|
Zfish   112 VAQILDFVSSQTSIPIVGISGGSAVVIPH-------KADGSTFLQMGASIDQQINAMFKVMEEYN 169

  Fly   158 WTRFIFL------YES-AEYLNILNELTTMLGKSGTVITVLRYDMQLNGNYKQVLRRVRKSVDNR 215
            |..|:.:      ||: .:|:....:.:..|.:   :..||.::|.:..|..:. ||:.:.||::
Zfish   170 WGNFVVITSLYPGYETFVDYIRSFTDTSYFLWE---LQDVLSFEMSVGANDIRT-RRLLQQVDSQ 230

  Fly   216 IVVVGSSETMPEFL-NQAQQVGIINEDYKYIIGNLDFHSFDLEEYKYSEANITGLRLFSPE---- 275
            :.:|..|....::| ..|..||::...|.:|                    :..|.:.:||
Zfish   231 VYLVYCSHEEAQYLFRMASDVGLLGPGYIWI--------------------VPSLAVGNPEAAPP 275

  Fly   276 ---KMAVKELLMKLGYPTDQDEFRNGSCPITVEMALTYDAVQLFAQTLKNLPFKPM-PQNCSQRT 336
               .:.|..::......|.:...|.|       :|:....|..|.   |:..|.|. ..:||...
Zfish   276 ASFPVGVISIITDRWRKTLRQRVREG-------VAIIVKGVHSFH---KHRGFIPEGHSDCSSPV 330

  Fly   337 ESVRDDGSSFKNYM------RTLRL-TDRLLTGPIYFEGNVRKGYHLDVIELQPSGIVKV--GTW 392
            :|..:: |.|::.:      :.|.. :|..||.|......:.:..|.|.:.....||:::  ..|
Zfish   331 KSYANN-SLFRHMLNVSWEHKDLSFNSDGYLTNPSMVIIALDRENHWDKVGSYEGGILQMRYPVW 394

  Fly   393 DEDRQYRPQRLAPTTAQFDSVDNSLANKTFIILLSVP--------------------------NK 431
            .....:    |.|.:........:|..:.|:|:.||.                          .:
Zfish   395 PRYGSF----LEPVSDNRHLTVATLEERPFVIVESVDPATGTCVRNTVPCRRQSNRTESIIGHTE 455

  Fly   432 PYAQLVETYKQLEGNSQYEGYGVDLIKELADKLGFNFTF---VNGGND---YGSYNKSTNESTGM 490
            ||.:|.           .:|:.:|::|:|:..:.|::..   .||.:.   .|.:|       ||
Zfish   456 PYTKLC-----------CKGFCIDILKKLSRTIKFSYDLYLVTNGKHGKMVRGVWN-------GM 502

  Fly   491 LREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWF 555
            :.|:...|||:||..|||..||.:.:||::||:..||:::..: ...|.....|::|:|..||..
Zfish   503 IGEVFYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVAR-SNGTVSPSAFLEPYSPAVWVM 566

  Fly   556 LGFSFLG-VSLSFFILGRLSPSEWDNPYPCIEEPEELENQFTLGNSIWFTTGALLQQGSEI-GPK 618
            :....|. |:::.|:....||..::......:.|.  ...||:|.|:|...|.:......| .||
Zfish   567 MFVMCLTVVAVTVFVFEYFSPVGYNRSLVSAKAPG--GPTFTIGKSVWLLWGIVFNNSVPIENPK 629

  Fly   619 ALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNK--------DGVVYGAK 675
            ..:::.:...|.||.:|.::|||||||||:..|:   .|::|..|:|.|        ....:|..
Zfish   630 GTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQ---YIDTVSGLSDKKFQKPQEHYPPFRFGTV 691

  Fly   676 KTGSTRNFFMTSAEERYKKMNKFMSENPQYLTEDNMEGVNRVKTNTHYAFLMESTSIEYNTKRE- 739
            ..|||.....::..:.:..|.|:..:..:       |.:|.:||....||:.::..:.|...::
Zfish   692 PNGSTERNIRSNYPDMHTHMIKYNQKGVE-------EALNSLKTGKLDAFIYDAAVLNYMAGKDE 749

  Fly   740 -CNLKKIGD--ALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTGICATKE 801
             |.|..||.  .....|||||::||...:...:.|||:....|..::::..|.    :|||..::
Zfish   750 GCKLVTIGSGKVFATTGYGIALQKDSRWKRPIDLALLQFLGDGDTQRLETVWL----SGICQNEK 810

  Fly   802 DAPDATPLDMNNLEGVFFVLLVGSCCALLYGIISWVLFVMKKAHHYRVPLRDALKEEFQFVIDFN 866
            :...::.||::|:.|||::|||....:||  :.:|...:..|..| .|...|.|        ||
Zfish   811 NEVMSSKLDIDNMAGVFYMLLVAMGLSLL--VFAWEHLLYWKLRH-SVHKSDRL--------DF- 863

  Fly   867 NYVRVLKNSASIYS 880
                :|..|..|||
Zfish   864 ----LLAISRGIYS 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	64/327 (20%)
		ANF_receptor	51..382	CDD:279440	61/311 (20%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	104/416 (25%)
		Lig_chan	551..824	CDD:278489	76/286 (27%)
grin2cb	XP_009305071.2	PBP1_iGluR_NMDA_NR2	37..396	CDD:107373	64/325 (20%)
		PBP2_iGluR_NMDA_Nr2	407..808	CDD:270436	108/435 (25%)
		NMDAR2_C	845..>932	CDD:313729	12/43 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591321
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740