Protein Alignment GluRIIE and grin2cb

DIOPT Version :10

• Sequence 1: NP_001036733.1
• Gene: GluRIIE / 318623
• FlyBaseID: FBgn0051201
• Length: 897
• Species: Drosophila melanogaster
• Sequence 2: XP_009305071.3
• Gene: grin2cb / 100333648
• ZFINID: ZDB-GENE-100308-2
• Length: 1328
• Species: Danio rerio
• Alignment Length: 859
• Identity: 198/859 - (23%)
• Similarity: 360/859 - (41%)
• Gaps: 173/859 - (20%)

  Fly    98 IAGVFGPSSRHTAVHLMSIC--DAMDIPHIYSYMSENAEGFNLHPHPADL---AKALYSLITEFN 157
            :|.:....|..|::.::.|.  .|:.|||       .|:|.......|.:   ..|::.::.|:|
Zfish   112 VAQILDFVSSQTSIPIVGISGGSAVVIPH-------KADGSTFLQMGASIDQQINAMFKVMEEYN 169

  Fly   158 WTRFIFL------YES-AEYLNILNELTTMLGKSGTVITVLRYDMQLNGNYKQVLRRVRKSVDNR 215
            |..|:.:      ||: .:|:....:.:..|.:   :..||.::|.:..|..:. ||:.:.||::
Zfish   170 WGNFVVITSLYPGYETFVDYIRSFTDTSYFLWE---LQDVLSFEMSVGANDIRT-RRLLQQVDSQ 230

  Fly   216 IVVVGSSETMPEFL-NQAQQVGIINEDYKYIIGNLDFHSFDLEEYKYSEANITGLRLFSPE---- 275
            :.:|..|....::| ..|..||::...|.:|                    :..|.:.:||
Zfish   231 VYLVYCSHEEAQYLFRMASDVGLLGPGYIWI--------------------VPSLAVGNPEAAPP 275

  Fly   276 ---KMAVKELLMKLGYPTDQDEFRNGSCPITVEMALTYDAVQLFAQTLKNLPFKPM-PQNCSQRT 336
               .:.|..::......|.:...|.|       :|:....|..|.   |:..|.|. ..:||...
Zfish   276 ASFPVGVISIITDRWRKTLRQRVREG-------VAIIVKGVHSFH---KHRGFIPEGHSDCSSPV 330

  Fly   337 ESVRDDGSSFKNYM------RTLRL-TDRLLTGPIYFEGNVRKGYHLDVIELQPSGIVKV--GTW 392
            :|..:: |.|::.:      :.|.. :|..||.|......:.:..|.|.:.....||:::  ..|
Zfish   331 KSYANN-SLFRHMLNVSWEHKDLSFNSDGYLTNPSMVIIALDRENHWDKVGSYEGGILQMRYPVW 394

  Fly   393 DEDRQYRPQRLAPTTAQFDSVDNSLANKTFIILLSVP--------------------------NK 431
            .....:    |.|.:........:|..:.|:|:.||.                          .:
Zfish   395 PRYGSF----LEPVSDNRHLTVATLEERPFVIVESVDPATGTCVRNTVPCRRQSNRTESIIGHTE 455

  Fly   432 PYAQLVETYKQLEGNSQYEGYGVDLIKELADKLGFNFTF---VNGGND---YGSYNKSTNESTGM 490
            ||.:|.           .:|:.:|::|:|:..:.|::..   .||.:.   .|.:|       ||
Zfish   456 PYTKLC-----------CKGFCIDILKKLSRTIKFSYDLYLVTNGKHGKMVRGVWN-------GM 502

  Fly   491 LREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWF 555
            :.|:...|||:||..|||..||.:.:||::||:..||:::..: ...|.....|::|:|..||..
Zfish   503 IGEVFYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVAR-SNGTVSPSAFLEPYSPAVWVM 566

  Fly   556 LGFSFLG-VSLSFFILGRLSPSEWDNPYPCIEEPEELENQFTLGNSIWFTTGALLQQGSEI-GPK 618
            :....|. |:::.|:....||..::......:.|.  ...||:|.|:|...|.:......| .||
Zfish   567 MFVMCLTVVAVTVFVFEYFSPVGYNRSLVSAKAPG--GPTFTIGKSVWLLWGIVFNNSVPIENPK 629

  Fly   619 ALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNK--------DGVVYGAK 675
            ..:::.:...|.||.:|.::|||||||||:..|:   .|::|..|:|.|        ....:|..
Zfish   630 GTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQ---YIDTVSGLSDKKFQKPQEHYPPFRFGTV 691

  Fly   676 KTGSTRNFFMTSAEERYKKMNKFMSENPQYLTEDNMEGVNRVKTNTHYAFLMESTSIEYNTKRE- 739
            ..|||.....::..:.:..|.|:..:..:       |.:|.:||....||:.::..:.|...::
Zfish   692 PNGSTERNIRSNYPDMHTHMIKYNQKGVE-------EALNSLKTGKLDAFIYDAAVLNYMAGKDE 749

  Fly   740 -CNLKKIGD--ALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTGICATKE 801
             |.|..||.  .....|||||::||...:...:.|||:....|..::::..|.    :|||..::
Zfish   750 GCKLVTIGSGKVFATTGYGIALQKDSRWKRPIDLALLQFLGDGDTQRLETVWL----SGICQNEK 810

  Fly   802 DAPDATPLDMNNLEGVFFVLLVGSCCALLYGIISWVLFVMKKAHHYRVPLRDALKEEFQFVIDFN 866
            :...::.||::|:.|||::|||....:||  :.:|...:..|..| .|...|.|        ||
Zfish   811 NEVMSSKLDIDNMAGVFYMLLVAMGLSLL--VFAWEHLLYWKLRH-SVHKSDRL--------DF- 863

  Fly   867 NYVRVLKNSASIYS 880
                :|..|..|||
Zfish   864 ----LLAISRGIYS 873

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	40..402	CDD:380605	64/333 (19%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	104/416 (25%)
		Lig_chan	551..824	CDD:459656	76/286 (27%)
grin2cb	XP_009305071.3	None