DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIIE and si:dkey-183j2.10

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	XP_001923977.1	Gene:	si:dkey-183j2.10 / 100151589	ZFINID:	ZDB-GENE-130530-729	Length:	465	Species:	Danio rerio

Alignment Length:	449	Identity:	141/449 - (31%)
Similarity:	229/449 - (51%)	Gaps:	68/449 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   417 LANKTFIILLSVPNKPYAQLVETYKQLEGNSQYEGYGVDLIKELADKLGFNFT--FVNGGNDYGS 479
            :|.:..:|:.::...||.        :...||.|||.:||:.|||.||||.:.  .|..|: ||.
Zfish    25 IAARQELIVTTIKQDPYT--------MSKGSQLEGYCMDLLTELAKKLGFKYKVHLVKDGS-YGR 80

  Fly   480 YNKSTNESTGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPE--LF 542
            .:::.|.: ||:.|::.|.||||:..||:|:.||:|:..|.|:|..||:|| |:....:.|  .|
Zfish    81 QDENGNWN-GMIGEVVRGEADLAVAPLTLTAAREKAVGMTKPYMQTGISIL-LRKDIVSEEAGFF 143

  Fly   543 TFMDPFSEEVWWFLGFSFLGVSLSFFILGRLSPSEWDNPYPCIEEPEELENQFTLGNSIWFTTGA 607
            .|:.|||.|.|:.:..::...::...|:|||||.||       .:||...|.|||.:|:|:|.||
Zfish   144 DFLSPFSGETWFGILIAYFVTAVCICIVGRLSPCEW-------SQPETEPNHFTLLHSLWYTAGA 201

  Fly   608 LLQQGSEIGPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVY 672
            |..||:...|||:|.|.::..||.|.:::::.|.::|::....:....:|...:||| |:|.:.|
Zfish   202 LSLQGAGPHPKAVSGRVISCTWWLFAVVLLACYFSSLSSTQGSDSAPLMIKGFEDLA-NQDVIEY 265

  Fly   673 GAKKTGSTRNFFMTSAEERYKKMNKFMSENPQYLTEDNMEGVNRVKTNTHYAFLMESTSIEYNTK 737
            |.....||..||..|....|:::.:.|.....:::..: |||.:.|.. :|||:.||.|::....
Zfish   266 GTLAGSSTLAFFKNSNNPSYRRIYEHMERRKSFVSSMD-EGVQKAKEG-NYAFIGESVSLDLAVA 328

  Fly   738 RECNLKKIGDALDEKGY------GIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTGI 796
            |.|.|.:..:.:..:||      |.||.|:      .:.|:|:|.|.|.|..::.|||    ...
Zfish   329 RHCELVRAHEVIGMRGYSIVTPLGSAMLKN------LSVAILQLSEAGELAYLRTKWW----ASS 383

  Fly   797 CATKEDAPDATPLDMNNLEGVFFVLLVG-------------------------SCCALL 830
            |.  .|...|:.|..::::|:|.||.:|                         |||.:|
Zfish   384 CL--PDNAKASSLRAHSMKGIFLVLAIGLGIGVLLSLFELTTKSRSAAGEQKKSCCTVL 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377
		ANF_receptor	51..382	CDD:279440
		PBP2_iGluR_Kainate	419..790	CDD:270432	126/380 (33%)
		Lig_chan	551..824	CDD:278489	85/278 (31%)
si:dkey-183j2.10	XP_001923977.1	PBP2_iGluR_non_NMDA_like	28..381	CDD:270403	127/383 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	5	4.770