DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31198 and NPEPPS

DIOPT Version :9

Sequence 1:	NP_732654.1	Gene:	CG31198 / 318622	FlyBaseID:	FBgn0051198	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	XP_016880861.1	Gene:	NPEPPS / 9520	HGNCID:	7900	Length:	924	Species:	Homo sapiens

Alignment Length:	896	Identity:	261/896 - (29%)
Similarity:	426/896 - (47%)	Gaps:	100/896 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 RLAEHITPVNYNITLRPYLLETDGNKRFTFDGEVWIEVISNQTTNDIYLHSKNLTYSVREYWQKP 106
            ||...::|:||::.|:|.||:      |||:|::.......|.||.|.::..::......|..:.
Human    53 RLPADVSPINYSLCLKPDLLD------FTFEGKLEAAAQVRQATNQIVMNCADIDIITASYAPEG 111

  Fly   107 TTEVANPTVIQISATNTTNYDTDIVKLTASTALTANT-TYILHFVYTGLMEDDMHGFYRSSYVDD 170
            ..|        |.||. .||..:..|:|.|...|..| |..|...:.|.:.|.|.|||||.|...
Human   112 DEE--------IHATG-FNYQNEDEKVTLSFPSTLQTGTGTLKIDFVGELNDKMKGFYRSKYTTP 167

  Fly   171 NNVTKWLGSTQFQTHHARRAFPSFDEPQFKATFDVTLKRHRTFNSVSNTRLI--SSYPSTEEGIF 233
            :...::...|||:...||||||.:|||..|||||::|...:...::||..:|  ..||. :|.:.
Human   168 SGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPD-DENLV 231

  Fly   234 SDVYKTTPKMSTYLLAFIISE--FVARKDDD---FGVYARPEYYAQTQYPYNVGIQILEEMGQYL 293
            ...:..||.|||||:||::.|  ||..:..|   ..||.......|.::...|..:.|.     .
Human   232 EVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGKFALEVAAKTLP-----F 291

  Fly   294 DKDYYSMGN--DKMDMAAIPDFSAGAMENWGLLTYRERSLLVDESATTLASRQSIAAVVAHEQAH 356
            .|||:::..  .|:|:.||.||:|||||||||:||||.:||:|...:..:|||.:|.||.||.||
Human   292 YKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHELAH 356

  Fly   357 MWFGDLVTCKWWSYTWLNEGFARYFQYFGTAMVEDKWELEKQFVVDQVQSVMAMDSTNATNPLSD 421
            .|||:|||.:||::.|||||||.:.:|........::::..|||.........:|:.:.::|: :
Human   357 QWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALDNSHPI-E 420

  Fly   422 ENTYTPAHLSRMFNSISYNKGATFIRMIKHTMGEQQFQKSLQEYLKKYEYQSSLPEYLLGAWQAN 486
            .:...|:.:..:|::|||:|||:.|||:...:|::.|:|.:..||.|::.:::..|.|   |:
Human   421 VSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAATEDL---WE-- 480

  Fly   487 WPNSSYNESSKDI---FKSFTEQVGYPLINVTVGNSQ----VSFTQKRFLLKESDGSDSSLKYTV 544
               |..|.|.|.|   ..::|:|:|:|||.|.....:    :..:||:|....|...:...::.|
Human   481 ---SLENASGKPIAAVMNTWTKQMGFPLIYVEAEQVEDDRLLRLSQKKFCAGGSYVGEDCPQWMV 542

  Fly   545 PISYTTSETNNFLNTTPKFIL-KPNVTTTVQFNSTIKWIVVNIQQTGYYRVTYSDDNWHAIHHAL 608
            ||:.:|||..|  ....|.:: ||.:...::.....:|:.:|:...|:||..||.        |:
Human   543 PITISTSEDPN--QAKLKILMDKPEMNVVLKNVKPDQWVKLNLGTVGFYRTQYSS--------AM 597

  Fly   609 ITANWGGIHE-----NNRAQIVDDLFNLARAGYVTYNLTLDVIEYLQTETNYIPWTSAFNGFNYL 668
            :.:...||.:     .:|..:.:|||:|||||.::....|.|:|....|.||..|:........|
Human   598 LESLLPGIRDLSLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLGIL 662

  Fly   669 TIRLGNDTADFNYYIQTLTNKAYN----QLGFNEASNDTALDIYLRTKILSWACRYGSSDCISQA 729
            :..|.:  .||...||......::    :||::....:..||..||..:|....:.|....:.:|
Human   663 STLLSH--TDFYEEIQEFVKDVFSPIGERLGWDPKPGEGHLDALLRGLVLGKLGKAGHKATLEEA 725

  Fly   730 QGYF----QSLATVPKNIRATVYCVGLREGGEAEFQALYNKFKNETVATEETLLQNSFGCVKTQS 790
            :..|    :....:..::|:.||...|:.|.......:....|...:..|:..::...|......
Human   726 RRRFKDHVEGKQILSADLRSPVYLTVLKHGDGTTLDIMLKLHKQADMQEEKNRIERVLGATLLPD 790

  Fly   791 LIEKVFDLIISDEIRRQDKSSVLATLYTENNENVSPVFALVTQKYEELAEA-MGGYSAVATVISN 854
            ||:||....:|:|:|.||..||:..:...:.......:..:...:|||... .||:
Human   791 LIQKVLTFALSEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELYNRYQGGF--------- 846

  Fly   855 IAARFTTNQQLTD----LENFNKANGAKFGSSQATLTAAEATVKENLEWAT 901
            :.:|....|.||.    |.:.......:.|||:             |.|.|
Human   847 LISRLIKVQWLTPVIPALWDAEVGRSPEVGSSR-------------LSWPT 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31198	NP_732654.1	Peptidase_M1	42..442	CDD:279741	143/409 (35%)
		M1_APN_2	50..510	CDD:189008	163/472 (35%)
		ERAP1_C	582..898	CDD:288671	73/333 (22%)
NPEPPS	XP_016880861.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820