DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31198 and AAP1

DIOPT Version :9

Sequence 1:	NP_732654.1	Gene:	CG31198 / 318622	FlyBaseID:	FBgn0051198	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_011913.1	Gene:	AAP1 / 856443	SGDID:	S000001089	Length:	856	Species:	Saccharomyces cerevisiae

Alignment Length:	908	Identity:	243/908 - (26%)
Similarity:	443/908 - (48%)	Gaps:	97/908 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 LAEHITPVNYNITLRPYLLETDGNKRFTFDGEVWIEVISNQTTNDIYLHSKNLTYSVREYWQKPT 107
            |..::||::|:|||.|..      :.|||:|.:.|::    ..||..::|..:.|...::   .:
Yeast     6 LPNNVTPLHYDITLEPNF------RAFTFEGSLKIDL----QINDHSINSVQINYLEIDF---HS 57

  Fly   108 TEVANPTVIQISATNTTNYDTDIVKLTASTALTANTTY-------ILHFVYTGLMEDDMHGFYRS 165
            ..:.....|:::......         .:|.:..|.|:       .|..:::|::.|.|.||||:
Yeast    58 ARIEGVNAIEVNKNENQQ---------KATLVFPNGTFENLGPSAKLEIIFSGILNDQMAGFYRA 113

  Fly   166 SYVDD-NNVTKWLGSTQFQTHHARRAFPSFDEPQFKATFDVTLKRHRTFNSVSNTRLISSYPSTE 229
            .|.|. ...||::.:||.:...||||||.||||..||||.|||........:||..:.:.  :.:
Yeast   114 KYTDKVTGETKYMATTQMEATDARRAFPCFDEPNLKATFAVTLVSESFLTHLSNMDVRNE--TIK 176

  Fly   230 EGIFSDVYKTTPKMSTYLLAFIISEFVARKDDDF----GVYARPEYYAQTQYPYNVGIQILEEMG 290
            ||.....:.|||||||||:|||:::....:.::|    .||:.|......|:..|:..:.|....
Yeast   177 EGKKYTTFNTTPKMSTYLVAFIVADLRYVESNNFRIPVRVYSTPGDEKFGQFAANLAARTLRFFE 241

  Fly   291 QYLDKDYYSMGNDKMDMAAIPDFSAGAMENWGLLTYRERSLLVDESATTLASRQSIAAVVAHEQA 355
            ...:.:|   ...||||.|:.:|||||||||||:|||...||:|...::|...|.:|.|:.||.|
Yeast   242 DTFNIEY---PLPKMDMVAVHEFSAGAMENWGLVTYRVIDLLLDIENSSLDRIQRVAEVIQHELA 303

  Fly   356 HMWFGDLVTCKWWSYTWLNEGFARYFQYFGTAMVEDKWELEKQFVVDQVQSVMAMDSTNATNPL- 419
            |.|||:|||..||...|||||||.:..::.....:.:|::.:|:|.|.:|..:.:||..:::|:
Yeast   304 HQWFGNLVTMDWWEGLWLNEGFATWMSWYSCNKFQPEWKVWEQYVTDNLQRALNLDSLRSSHPIE 368

  Fly   420 -----SDENTYTPAHLSRMFNSISYNKGATFIRMIKHTMGEQQFQKSLQEYLKKYEYQSSLPEYL 479
                 :||       ::::|::|||:||::.:|||...:||:.|.|.:.:||.|::|.::....|
Yeast   369 VPVNNADE-------INQIFDAISYSKGSSLLRMISKWLGEETFIKGVSQYLNKFKYGNAKTGDL 426

  Fly   480 LGAWQANWPNSSYNESSKD---IFKSFTEQVGYPLINVTVGNSQVSFTQKRFL----LKESDGSD 537
               |.|     ..:.|.||   :...:|::||:|:::|....::::.||.|:|    :||.:  |
Yeast   427 ---WDA-----LADASGKDVCSVMNIWTKRVGFPVLSVKEHKNKITLTQHRYLSTGDVKEEE--D 481

  Fly   538 SSLKYTVPISYTTSETNNFLNTTPKFILKPNVTTTVQFNSTIKWIVVNIQQTGYYRVTYSDDNWH 602
            :::   .||.....::....||   .:|.....|....|.  ::..:|..|:|.:..:|||:.|
Yeast   482 TTI---YPILLALKDSTGIDNT---LVLNEKSATFELKNE--EFFKINGDQSGIFITSYSDERW- 537

  Fly   603 AIHHALITANWGGIHENNRAQIVDDLFNLARAGYVTYNLTLDVIEYLQTETNYIPWTSAFNGFNY 667
                |.::.....:...:|..:|.|...|:.:||.:....|::|...:.|.:::.|....|..:.
Yeast   538 ----AKLSKQANLLSVEDRVGLVADAKALSASGYTSTTNFLNLISNWKNEDSFVVWEQIINSLSA 598

  Fly   668 LTIRLGNDTADF-----NYYIQTLTNKAYNQLGFNEASNDTALDIYLRTKILSWACRYGSSDCIS 727
            |......:..|.     .:.:..:.|| .::||:|...:|:.....|:..:.|.||..|:....|
Yeast   599 LKSTWVFEPEDILNALDKFTLDLVLNK-LSELGWNIGEDDSFAIQRLKVTLFSAACTSGNEKMQS 662

  Fly   728 QAQGYFQSLA-----TVPKNIRATVYCVGLREGGEAEFQALYNKFKNETVATEETLLQNSFGCVK 787
            .|...|:..|     .:|...:|.|:....|.|||..::.::|.::|...:.|:.:...:.|..:
Yeast   663 IAVEMFEEYANGNKQAIPALFKAVVFNTVARLGGENNYEKIFNIYQNPVSSEEKIIALRALGRFE 727

  Fly   788 TQSLIEKVFDLIISDEIRRQDKSSVLATLYTENNENVSPVFALVTQKYEELAEAM-GGYSAVATV 851
            .:.|:|:....::...:..||....:..:.. :.:.:..::|.:.:.::|:|:.: .|...:..|
Yeast   728 DKELLERTLSYLLDGTVLNQDFYIPMQGIRV-HKKGIERLWAWMQEHWDEIAKRLQPGSPVLGGV 791

  Fly   852 ISNIAARFTTNQQLTDLENFNKANGAKFGSSQATLTAAEATVKENLEWATAKLGVFRSYLANY 914
            ::.....||:.:.|..:..|......| |..| ||..|..|::...:|.:....:..:||..:
Yeast   792 LTLGLTNFTSFEALEKISAFYSRKVTK-GFDQ-TLAQALDTIRSKAQWVSRDREIVATYLREH 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31198	NP_732654.1	Peptidase_M1	42..442	CDD:279741	135/416 (32%)
		M1_APN_2	50..510	CDD:189008	154/480 (32%)
		ERAP1_C	582..898	CDD:288671	67/326 (21%)
AAP1	NP_011913.1	PepN	2..844	CDD:223385	241/898 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
TreeFam	0	0.000	Not matched by this tool.
	5	4.910