Protein Alignment CG31198 and AOPEP

DIOPT Version :10

• Sequence 1: NP_732654.1
• Gene: CG31198 / 318622
• FlyBaseID: FBgn0051198
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: NP_001372995.1
• Gene: AOPEP / 84909
• HGNCID: 1361
• Length: 859
• Species: Homo sapiens
• Alignment Length: 542
• Identity: 113/542 - (20%)
• Similarity: 192/542 - (35%)
• Gaps: 145/542 - (26%)

  Fly    65 GNKRFTFDGEVWIEVISNQTTNDIYLHSKNLTYSVREY-------WQKPTTEVANPTVIQISATN 122
            |.::||...|  :.|:|.:..|.|          |||.       |::.....|..:  |.....
Human   166 GLEKFTRSPE--LTVVSEEFRNQI----------VRELVTLPANRWREQLDYYARCS--QAPGCG 216

  Fly   123 TTNYDTDIVKLTASTALTANTTYILHFVYTGLM--EDDMHG---FYRSSYVDDNNVTKWLGS--- 179
            ...:|||              |:.|....||..  .|..|.   :|::. .:..:|| |...
Human   217 ELLFDTD--------------TWSLQIRKTGAQTATDFPHAIRIWYKTK-PEGRSVT-WTSDQSG 265

  Fly   180 -----TQFQTHHARRAFPSFDEPQFKATFDVTLKRHRTF-------NSVSNTRLISSYPSTEEGI 232
                 |.....:.|..||..:.|...:|:..|::...:|       ||...|:|      .||..
Human   266 RPCVYTVGSPINNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGENSAKPTQL------WEECS 324

  Fly   233 FSDVYKTTP-KMSTYLLA----------------------FIISEFVARKDDDFGVYARPEY--- 271
            ....|.|.| ..||:.:|                      |..||...|   ..||.:..||
Human   325 SWYYYVTMPMPASTFTIAVGCWTEMKMETWSSNDLATERPFSPSEANFR---HVGVCSHMEYPCR 386

  Fly   272 ----YAQTQ--YPYNVGIQI----------LEEMGQYLDKDYYSMGN---DKMDMAAIP-DFSAG 316
                .|.||  .|:.|...:          |..:...|...:..:|.   .::|:..:| :|.:.
Human   387 FQNASATTQEIIPHRVFAPVCLTGACQETLLRLIPPCLSAAHSVLGAHPFSRLDVLIVPANFPSL 451

  Fly   317 AMENWGLLTYRERSLLVDESATTLASRQSIAAVVAHEQAHMWFGDLVTCKWWSYTWLNEGFARYF 381
            .|.:..:: :..:|:|.       .........:.||.||.|||..:..:.|:..||:||||.:.
Human   452 GMASPHIM-FLSQSILT-------GGNHLCGTRLCHEIAHAWFGLAIGARDWTEEWLSEGFATHL 508

  Fly   382 Q--YFGTAM------VEDKWEL-----------EKQFVVDQVQSVMAMDSTNATNPLSDENTYTP 427
            :  ::.||.      ..::.||           |.|...:::|  :...|.:.|...||......
Human   509 EDVFWATAQQLAPYEAREQQELRACLRWRRLQDEMQCSPEEMQ--VLRPSKDKTGHTSDSGASVI 571

  Fly   428 AH---LSRMFNSISYNKGATFIRMIKHTMGEQQFQKSLQEYLKKYEYQSSLPEYLLGAWQANWPN 489
            .|   ..::|..:.|.||...:|.:...:|::.:...|::::..:..|..|.:..|.....|.|.
Human   572 KHGLNPEKIFMQVHYLKGYFLLRFLAKRLGDETYFSFLRKFVHTFHGQLILSQDFLQMLLENIPE 636

  Fly   490 SSYNE-SSKDIFKSFTEQVGYP 510
            ....| |.::|::.:.|..|.|
Human   637 EKRLELSVENIYQDWLESSGIP 658

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31198	NP_732654.1	M1_APN-Q_like	50..505	CDD:341064	110/535 (21%)
		ERAP1_C	581..898	CDD:463368
AOPEP	NP_001372995.1	GluZincin	<244..652	CDD:472708	87/428 (20%)
		Nucleolar localization signal. /evidence=ECO:0000250|UniProtKB:Q8BXQ6	689..699
		Leuk-A4-hydro_C	721..>771	CDD:462686