DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31198 and Erap1

DIOPT Version :9

Sequence 1:	NP_732654.1	Gene:	CG31198 / 318622	FlyBaseID:	FBgn0051198	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_109636.1	Gene:	Erap1 / 80898	MGIID:	1933403	Length:	930	Species:	Mus musculus

Alignment Length:	926	Identity:	260/926 - (28%)
Similarity:	453/926 - (48%)	Gaps:	95/926 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 NEYRLAEHITPVNYNITLRPYLLETDGNKRFTFDGEVWIEVISNQTTNDIYLHSKNLTYSVREYW 103
            |..||.|::||::|::.:...|      ...||.|:..:|:|:::.|:.|.:||.:|..|
Mouse    39 NNMRLPEYMTPIHYDLMIHANL------STLTFWGKTEVEIIASRPTSTIIMHSHHLQIS----- 92

  Fly   104 QKPTTEVANPTVIQISATNTTNYDT-DIVKLTASTALTANTTYILHFVYTGLMEDDMHGFYRSSY 167
             |.|.......::.........|.. :.|.|.|:..|.|.:.|.:...|...:.:..||||:|:|
Mouse    93 -KATLRRGAGEMLSEEPLKVLEYPAHEQVALLAAQPLLAGSLYTVIIDYAANLSESFHGFYKSTY 156

  Fly   168 VDDNNVTKWLGSTQFQTHHARRAFPSFDEPQFKATFDVTLKRHRTFNSVSNTRLISSYPSTEEGI 232
            .......:.|.:|||:...||.|||.||||..||:|.:.:||.....::||..|:.|. :..||:
Mouse   157 RTQEGEMRILAATQFEPTAARMAFPCFDEPALKASFSIKIKRDPRHLAISNMPLVKSV-NVAEGL 220

  Fly   233 FSDVYKTTPKMSTYLLAFIISEF-----VARKDDDFGVYARPEYYAQTQYPYNVGIQILEEMGQY 292
            ..|.:..|.||||||:|||||:|     :.:......|||.|:...|..|..:..:.:||
Mouse   221 IEDHFDITVKMSTYLVAFIISDFKSVSKMTKSGVKVSVYAVPDKINQADYALDAAVTLLE----- 280

  Fly   293 LDKDYYSMGN--DKMDMAAIPDFSAGAMENWGLLTYRERSLLVDESATTLASRQSIAAVVAHEQA 355
            ..:||:::..  .|.|:||||||.:||||||||.||||.|||.|:..::.:|:..|..:|:||.|
Mouse   281 FYEDYFNIPYPLPKQDLAAIPDFQSGAMENWGLTTYRESSLLYDKEKSSASSKLGITMIVSHELA 345

  Fly   356 HMWFGDLVTCKWWSYTWLNEGFARYFQYFGTAMVEDKWELEKQFVVDQVQSVMAMDSTNATNPLS 420
            |.|||:|||.:||:..|||||||::.::....:...:.::|..| ..:..:.|.:|:.|:::|:|
Mouse   346 HQWFGNLVTMEWWNDLWLNEGFAKFMEFVSVTVTHPELKVEDYF-FGKCFNAMEVDALNSSHPVS 409

  Fly   421 D--ENTYTPAHLSRMFNSISYNKGATFIRMIKHTMGEQQFQKSLQEYLKKYEYQSSLPEYLLGAW 483
            .  ||   ||.:..||:.:||.|||..:.|::..:....|::.:.:||:||.|:::..|.|..:.
Mouse   410 TPVEN---PAQIREMFDDVSYEKGACILNMLRDYLSADTFKRGIVQYLQKYSYKNTKNEDLWNSM 471

  Fly   484 QANWP------------NSSYNESS----------KDIFKSFTEQVGYPLINVTVGNSQVSFTQK 526
            ....|            .|.::.|:          |.:..::|.|.|:|||.:||....|...|:
Mouse   472 MHICPTDGTQTMDGFCSRSQHSSSTSHWRQEVVDVKTMMNTWTLQKGFPLITITVSGRNVHMKQE 536

  Fly   527 RFLLKESDGSDSSLKYTVPISYTTSETNNFLNTTPKFILKPNVTTTVQFNSTIKWIVVNIQQTGY 591
            .::.......::...:.||:::.||::    ::..:|:||.. |..:.....::||..|:...||
Mouse   537 HYMKGSERFPETGYLWHVPLTFITSKS----DSVQRFLLKTK-TDVLILPEAVQWIKFNVGMNGY 596

  Fly   592 YRVTYSDDNWHAIHHALITANWGGIHENNRAQIVDDLFNLARAGYVTYNLTLDVIEYLQTETNYI 656
            |.|.|:||.|.::...|..|: ..|..|:||.::::.|.|.....::....||:..||:.||..:
Mouse   597 YIVHYADDGWASLSGLLKEAH-TTISSNDRASLINNAFQLVSIEKLSIEKALDLTLYLKNETEIM 660

  Fly   657 PWTSAFNGFNYL-----------TIRLGNDTADFNYYIQTLTNKAYNQLGFNEASNDTALDIYLR 710
            |   .|...|.|           .|.:.....||  .::.|.:....|...:|.|....:   ||
Mouse   661 P---IFQALNELIPMYKLMEKRDMIEVETQFKDF--LLKLLKDLIDKQTWTDEGSVSERM---LR 717

  Fly   711 TKILSWACRYGSSDCISQAQGYFQSL------ATVPKNIRATVYCVGLREGGEAEFQALYNKFKN 769
            :::|..||......|:.:|:.||:..      .::|.::...|:.||.:.....:|  ||:|:::
Mouse   718 SQLLLLACVRNYQPCVQRAERYFREWKSSNGNMSIPIDVTLAVFAVGAQNTEGWDF--LYSKYQS 780

  Fly   770 ETVATEETLLQNSFGCVKTQSLIEKVFDLIISDEIRRQDKSSVLATLYTENNENVSPVFALVTQK 834
            ...:||::.::.|....|....::.:.|.....||.:..:...:.||...|.......:..:.:.
Mouse   781 SLSSTEKSQIEFSLCTSKDPEKLQWLLDQSFKGEIIKTQEFPHILTLIGRNPVGYPLAWKFLREN 845

  Fly   835 YEELAEAMG-GYSAVATVISNIAARFTTNQQLTDLENF---NKANGAKFGSSQATLTAAEATVKE 895
            :.:|.:... |.|::|.::.....:|:|..:|.:::.|   .|.||::....|.|:    .|::|
Mouse   846 WNKLVQKFELGSSSIAHMVMGTTDQFSTRARLEEVKGFFSSLKENGSQLRCVQQTI----ETIEE 906

  Fly   896 NLEWATAKLGVFRSYL 911
            |:.|........|.:|
Mouse   907 NIRWMDKNFDKIRLWL 922

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31198	NP_732654.1	Peptidase_M1	42..442	CDD:279741	143/409 (35%)
		M1_APN_2	50..510	CDD:189008	157/491 (32%)
		ERAP1_C	582..898	CDD:288671	78/336 (23%)
Erap1	NP_109636.1	M1_APN-Q_like	50..515	CDD:341064	154/486 (32%)
		Substrate binding. /evidence=ECO:0000250	306..310		3/3 (100%)
		ERAP1_C	586..905	CDD:403137	77/333 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920