DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31198 and Erap1

DIOPT Version :9

Sequence 1:	NP_732654.1	Gene:	CG31198 / 318622	FlyBaseID:	FBgn0051198	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	XP_006231762.1	Gene:	Erap1 / 80897	RGDID:	708542	Length:	954	Species:	Rattus norvegicus

Alignment Length:	1004	Identity:	280/1004 - (27%)
Similarity:	478/1004 - (47%)	Gaps:	147/1004 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PRVAVLLVACVSLASAGTRQLSVDVQPPATLATEL--NEYRLAEHITPVNYNITLRPYLLETDGN 66
            |.:..|::..::::|....|.|....|.|:.....  |..||.|:|||::|::.:...|
  Rat     2 PSLLSLVLTFLAVSSPSCCQNSDTASPKASNGASFLWNNMRLPEYITPIHYDLMIHANL------ 60

  Fly    67 KRFTFDGEVWIEVISNQTTNDIYLHSKNLTYSVREYWQKPTTEVANPTVIQISATNTTNYDT-DI 130
            ...||.|:..:|:..:|.|:.|.:||..|..|      |.|.......::.........|.. :.
  Rat    61 STLTFWGKTEVEITVSQPTSTIIMHSHQLQIS------KATLRRGAEEMLPEEPLKLMEYSAHEQ 119

  Fly   131 VKLTASTALTANTTYILHFVYTGLMEDDMHGFYRSSYVDDNNVTKWLGSTQFQTHHARRAFPSFD 195
            |.|..:..|.|.:.|.:...|...:.::.||||:|:|.......:.|.:|||:...||.|||.||
  Rat   120 VALLTAQPLLAGSVYTVIITYAANLSENFHGFYKSTYRTQEGERRILAATQFEPTAARMAFPCFD 184

  Fly   196 EPQFKATFDVTLKRHRTFNSVSNTRLISSYPSTEEGIFSDVYKTTPKMSTYLLAFIISEF----- 255
            ||..||:|.:.:||.....::||..|:.|. :..||:..|.:..|.||||||:|||||:|
  Rat   185 EPALKASFSIKIKRDPRHLAISNMPLVKSV-TVAEGLIEDHFDITVKMSTYLVAFIISDFKSVSK 248

  Fly   256 VARKDDDFGVYARPEYYAQTQYPYNVGIQILEEMGQYLDKDYYSMGN--DKMDMAAIPDFSAGAM 318
            :.:......|||.|:...|..|..:..:.:||     ..:||:|:..  .|.|:||||||.:|||
  Rat   249 MTKSGVKVSVYAVPDKINQADYALDAAVTLLE-----FYEDYFSIPYPLPKQDLAAIPDFQSGAM 308

  Fly   319 ENWGLLTYRERSLLVDESATTLASRQSIAAVVAHEQAHMWFGDLVTCKWWSYTWLNEGFARYFQY 383
            |||||.||||.:||.|:..::.:|:..|...|:||.||.|||:|||.:||:..|||||||::.::
  Rat   309 ENWGLTTYRESALLYDKEKSSASSKLGITMTVSHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEF 373

  Fly   384 FGTAMVEDKWEL-----------------------EKQFVVDQVQSVMAMDSTNATNPLSD--EN 423
            ....:...:.::                       |:::...:..:.|.:|:.|:::|:|.  ||
  Rat   374 VSVTVTHPELKVMQILTANHQNEPEDLSGRAMERTEEEYFFGKCFNAMEVDALNSSHPVSTPVEN 438

  Fly   424 TYTPAHLSRMFNSISYNKGATFIRMIKHTMGEQQFQKSLQEYLKKYEYQSSLPEYLLGAWQANWP 488
               ||.:..||:.:||.|||..:.|::..:....|::.:.:||:||.|:::..|.|..:.....|
  Rat   439 ---PAQIREMFDEVSYEKGACILNMLRDYLSADTFKRGIVQYLQKYSYKNTKNEDLWNSMMHICP 500

  Fly   489 NS---------SYNESS-------------KDIFKSFTEQVGYPLINVTVGNSQVSFTQKRFLLK 531
            ..         |.|:.|             |.:..::|.|.|:|||.:||....|...|:.::..
  Rat   501 TDGTQTMDGFCSRNQHSSSTSHWRQEVIDIKSMMNTWTLQKGFPLITITVRGRNVHLKQEHYMKG 565

  Fly   532 ESDGSDSSLKYTVPISYTTSETNNFLNTTPKFILKPNVTTTVQFNSTIKWIVVNIQQTGYYRVTY 596
            .....::...:.||:::.||::    ::..:|:||.. |..:.....::||..|:...|||.|.|
  Rat   566 SECFPETGSLWHVPLTFITSKS----DSVQRFLLKTK-TDVIILPEAVEWIKFNVGMNGYYIVHY 625

  Fly   597 SDDNWHAIHHALITANWGGIHENNRAQIVDDLFNLARAGYVTYNLTLDVIEYLQTETNYIPWTSA 661
            .||.|.:::..|..|: ..|..|:||.::::.|.|...|.::....||:|.||:.||..:|   .
  Rat   626 GDDGWASLNGLLKEAH-TTISSNDRASLINNAFQLVSIGKLSIEKALDLILYLKNETEIMP---I 686

  Fly   662 FNGFNYL-----------TIRLGNDTADFNY-YIQTLTNKAYNQLGFNEASNDTALDIYLRTKIL 714
            |.|.|.|           .:.:.....||.. .::.|.||   |...:|.|....:   ||:::|
  Rat   687 FQGLNELIPMYKLMEKRDMVEVETQFKDFLLRLLKDLINK---QTWTDEGSVSERM---LRSQLL 745

  Fly   715 SWACRYGSSDCISQAQGYFQSL------ATVPKNIRATVYCVGLREGGEAEFQALYNKFKNETVA 773
            ..||.:....|:.:|:.||:..      .::|.::...|:.||.:.....:|  ||:|:::...:
  Rat   746 LLACVHRYQLCVQRAERYFREWKASNGNMSLPIDVTLAVFAVGAQNTEGWDF--LYSKYQSSLSS 808

  Fly   774 TEETLLQNSFGCV-----KTQSLIEKVF--DLIISDE-------IRRQDKSSVLATLYTENNENV 824
            ||::.::.|. |:     |.|.|:::.|  ::|.:.|       |.|......||..:.:.|.|
  Rat   809 TEKSQIEFSL-CISQDPEKLQWLLDQSFKGEIIKTQEFPHILTLIGRNPVGYPLAWKFLKENWN- 871

  Fly   825 SPVFALVTQKYEELAEAMGGYSAVATVISNIAARFTTNQQLTDLENF---NKANGAKFGSSQATL 886
                 .:.||:|.      |.|::|.::.....:|:|..:|.:::.|   .|.||::....|.|:
  Rat   872 -----KIVQKFEL------GSSSIAHMVMGTTNQFSTRARLEEVKGFFSSLKKNGSQLRCVQQTI 925

  Fly   887 TAAEATVKENLEWATAKLGVFRSYLANYR 915
                .|::||:.|........|.:|...|
  Rat   926 ----ETIEENIRWMDKNFDKIRLWLQKER 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31198	NP_732654.1	Peptidase_M1	42..442	CDD:279741	142/432 (33%)
		M1_APN_2	50..510	CDD:189008	156/514 (30%)
		ERAP1_C	582..898	CDD:288671	90/350 (26%)
Erap1	XP_006231762.1	Peptidase_M1	42..454	CDD:279741	142/432 (33%)
		M1_APN_2	50..544	CDD:189008	156/514 (30%)
		ERAP1_C	611..927	CDD:288671	87/344 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920