DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31198 and ERAP2

DIOPT Version :9

Sequence 1:	NP_732654.1	Gene:	CG31198 / 318622	FlyBaseID:	FBgn0051198	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_001123612.1	Gene:	ERAP2 / 64167	HGNCID:	29499	Length:	960	Species:	Homo sapiens

Alignment Length:	1012	Identity:	271/1012 - (26%)
Similarity:	449/1012 - (44%)	Gaps:	175/1012 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 AVLLVACVSLASAGTRQLSVD-----VQPPATLATELN-------EYRLAEHITPVNYNITLRPY 59
            |:|...|:      ..|.||.     .:.|.......|       |.||...:.|::|::.:.|.
Human    27 AILPQICI------CSQFSVPSSYHFTEDPGAFPVATNGERFPWQELRLPSVVIPLHYDLFVHPN 85

  Fly    60 LLETDGNKRFTFDGEVWIEVISNQTTNDIYLHSK-----NLTYSVRE--YWQKPTTE---VANPT 114
            |...|      |.....|||:.:..|..|.||||     |.|....|  .:.||..|   ::.|.
Human    86 LTSLD------FVASEKIEVLVSNATQFIILHSKDLEITNATLQSEEDSRYMKPGKELKVLSYPA 144

  Fly   115 VIQISATNTTNYDTDIVKLTASTALTANTTYILHFVYTGLMEDDMHGFYRSSYVDDNNVTKWLGS 179
            ..||:             |.....||.:..|.:...:...:.|...|||:|:|......|:.|..
Human   145 HEQIA-------------LLVPEKLTPHLKYYVAMDFQAKLGDGFEGFYKSTYRTLGGETRILAV 196

  Fly   180 TQFQTHHARRAFPSFDEPQFKATFDVTLKRHRTFNSVSNTRLISSYPSTEEGIFSDVYKTTPKMS 244
            |.|:...||.|||.||||.|||.|.:.::|.....::||...:.:. ..|.|:..|.::||.|||
Human   197 TDFEPTQARMAFPCFDEPLFKANFSIKIRRESRHIALSNMPKVKTI-ELEGGLLEDHFETTVKMS 260

  Fly   245 TYLLAFIISEF-----VARKDDDFGVYARPEYYAQTQYPYNVGIQILEEMGQYLDKDYYSMGNDK 304
            |||:|:|:.:|     .........:||.|:...||.|.....:::|:...:|.| .||.:  .|
Human   261 TYLVAYIVCDFHSLSGFTSSGVKVSIYASPDKRNQTHYALQASLKLLDFYEKYFD-IYYPL--SK 322

  Fly   305 MDMAAIPDFSAGAMENWGLLTYRERSLLVDESATTLASRQSIAAVVAHEQAHMWFGDLVTCKWWS 369
            :|:.|||||:.||||||||:||||.|||.|...::.:.:..:..|:|||.||.|||:|||.:||:
Human   323 LDLIAIPDFAPGAMENWGLITYRETSLLFDPKTSSASDKLWVTRVIAHELAHQWFGNLVTMEWWN 387

  Fly   370 YTWLNEGFARYFQYFGTAMVEDKWELEKQFVVDQVQSVMAMDSTNATNPLSDENTYTPAHLSRMF 434
            ..||.||||:|.:.........:.:.:..| ::....|:..||.|::.|:| :...||..:..||
Human   388 DIWLKEGFAKYMELIAVNATYPELQFDDYF-LNVCFEVITKDSLNSSRPIS-KPAETPTQIQEMF 450

  Fly   435 NSISYNKGATFIRMIKHTMGEQQFQKSLQEYLKKYEYQSSLPEYLLGAWQANWPNSSY------- 492
            :.:||||||..:.|:|..:||::|||.:.:||||:.|:::..:.|..:...:...|.:
Human   451 DEVSYNKGACILNMLKDFLGEEKFQKGIIQYLKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCH 515

  Fly   493 ---------------NESSKDIFKSFTEQVGYPLINVTVGNSQVSFTQKRFL--LKESDGSDSSL 540
                           |...|::..::|.|.|.||:.|......:...|:|||  :.:.|....:|
Human   516 SDPKMTSNMLAFLGENAEVKEMMTTWTLQKGIPLLVVKQDGCSLRLQQERFLQGVFQEDPEWRAL 580

  Fly   541 K----YTVPISYTTSETNNFLNTTPKFILKPNVTTTVQFNSTIKWIVVNIQQTGYYRVTYSDDNW 601
            :    :.:|::|:||.:    |...:.||| :.|.|:.......|:..|:...|||.|.|....|
Human   581 QERYLWHIPLTYSTSSS----NVIHRHILK-SKTDTLDLPEKTSWVKFNVDSNGYYIVHYEGHGW 640

  Fly   602 HAI------HHALITANWGGIHENNRAQIVDDLFNLARAGYVTYNLTLDVIEYLQTETNYIPWTS 660
            ..:      :|.|       :...:|..::.|:|.|..||.:|.:..||:..|||.||:.   .:
Human   641 DQLITQLNQNHTL-------LRPKDRVGLIHDVFQLVGAGRLTLDKALDMTYYLQHETSS---PA 695

  Fly   661 AFNGFNYLTI-------RLGNDTAD------FNYYIQTLTNKAYNQLGFNEASNDTALDIYLRTK 712
            ...|.:||..       |..:|.::      ..|:...:..::::..|       :..|..||:.
Human   696 LLEGLSYLESFYHMMDRRNISDISENLKRYLLQYFKPVIDRQSWSDKG-------SVWDRMLRSA 753

  Fly   713 ILSWACRYGSSDCISQAQGYF------QSLATVPKNIRATVYCVGLREGGEAEFQALYNKFKNET 771
            :|..||....:.||.:|...|      .....:|.::...||.||.:.  .|.:..|..:::...
Human   754 LLKLACDLNHAPCIQKAAELFSQWMESSGKLNIPTDVLKIVYSVGAQT--TAGWNYLLEQYELSM 816

  Fly   772 VATEETLLQNSFGCVKTQSLIEKVFDL-----IISDE--------IRRQDKSSVLATLYTENNEN 823
            .:.|:..:..:....|.|..:.|:.:|     :|..:        |.|:.|...||..:...|
Human   817 SSAEQNKILYALSTSKHQEKLLKLIELGMEGKVIKTQNLAALLHAIARRPKGQQLAWDFVREN-- 879

  Fly   824 VSPVFALVTQKYEELAEAMGGYSAVATVISNIAARFTTNQQLTDLENF---NKANGAKFGSSQAT 885
                :..:.:|::     :|.|. :..:||...|.|::..:|.:::.|   .:|.|:.....|..
Human   880 ----WTHLLKKFD-----LGSYD-IRMIISGTTAHFSSKDKLQEVKLFFESLEAQGSHLDIFQTV 934

  Fly   886 LTAAEATVKENLEWATAKLGVFRSYLANYRSGSAMVN 922
            |    .|:.:|::|....|...|::|        |||
Human   935 L----ETITKNIKWLEKNLPTLRTWL--------MVN 959

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31198	NP_732654.1	Peptidase_M1	42..442	CDD:279741	139/414 (34%)
		M1_APN_2	50..510	CDD:189008	158/496 (32%)
		ERAP1_C	582..898	CDD:288671	74/356 (21%)
ERAP2	NP_001123612.1	Peptidase_M1	68..458	CDD:279741	139/414 (34%)
		M1_APN_2	76..548	CDD:189008	158/496 (32%)
		Substrate binding	334..338		3/3 (100%)
		ERAP1_C	621..938	CDD:288671	72/351 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920