DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31198 and Enpep

DIOPT Version :9

Sequence 1:	NP_732654.1	Gene:	CG31198 / 318622	FlyBaseID:	FBgn0051198	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_071587.2	Gene:	Enpep / 64017	RGDID:	621228	Length:	945	Species:	Rattus norvegicus

Alignment Length:	906	Identity:	264/906 - (29%)
Similarity:	447/906 - (49%)	Gaps:	98/906 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 ELNEYRLAEHITPVNYNITLRPYLLETDGNKRFTFDGEVWIEVISNQTTNDIYLHSKNLTYSVRE 101
            |...:||.:.|.||:|::.:: .|:|.|   |:|  |.|.|.|..::.|.|::||       :||
  Rat    79 EWKNFRLPDFIQPVHYDLEVK-VLMEED---RYT--GIVSISVNLSKDTRDLWLH-------IRE 130

  Fly   102 YWQKPTTEVANPTVIQISATNTTNY-DTDIVKLTASTALTA---NTTYILHFVYTGLMEDDMHGF 162
            .......|:..|:..|:.......| ..:.|.:.|...|.|   ::.|.|...:.|.:...:.||
  Rat   131 TRITKLPELRRPSGEQVPIRRCFEYKKQEYVVIQAEEDLAATSGDSVYRLTIEFEGWLNGSLVGF 195

  Fly   163 YRSSYVDDNNVTKWLGSTQFQTHHARRAFPSFDEPQFKATFDVTLKRHRTFNSVSNTRLISSYPS 227
            ||::|.:|.. ||.:.:|..:...||::||.||||..|||::::|...:.::::||..:     .
  Rat   196 YRTTYTEDGQ-TKSIAATDHEPTDARKSFPCFDEPNKKATYNISLIHPKEYSALSNMPV-----E 254

  Fly   228 TEEGIFSDVYKTT----PKMSTYLLAFIISEF-----VARKDDDFGVYARPEYYAQTQYPYNVGI 283
            .||.:.:|..|||    ..|||||:.|.:.:|     .:|......||.:|......:|..|:..
  Rat   255 KEETLDNDWKKTTFMKSVPMSTYLVCFAVHQFTSIQRTSRSGKPLTVYVQPNQKQTAEYAANITK 319

  Fly   284 QILEEMGQYLDKDYYSM--GNDKMDMAAIPDFSAGAMENWGLLTYRERSLLVDESATTLASRQSI 346
            .:.:     ..:||::|  ...|:|..|||||..||||||||:||||.:||.|...:..:::|.:
  Rat   320 AVFD-----FFEDYFAMEYSLPKLDKIAIPDFGTGAMENWGLVTYRETNLLYDPLLSASSNQQRV 379

  Fly   347 AAVVAHEQAHMWFGDLVTCKWWSYTWLNEGFARYFQYFGTAMVEDKWELEKQFVVDQVQSVMAMD 411
            |:|||||..|.|||::||..||...|||||||.:|::.|....|..|::..|.:::.|..|...|
  Rat   380 ASVVAHELVHQWFGNIVTMDWWDDLWLNEGFASFFEFLGVNHAEADWQMLSQVLLEDVLPVQEDD 444

  Fly   412 STNATNPLSDENTYTPAHLSRMFNSISYNKGATFIRMIKHTMGEQQFQKSLQEYLKKYEYQSSLP 476
            |..:::|:. ....|||.::.:|:.|||:|||:.:||::..:..::|||..|.||:.::::::..
  Rat   445 SLMSSHPVV-VTVSTPAEITSVFDGISYSKGASILRMLQDWITPEKFQKGCQIYLENFKFKNAKT 508

  Fly   477 EYLLGAWQANWPNSSYNESSKDIFKSFTEQVGYPLINVTVGNSQVSFTQKRFLLK-ESDGSD--S 538
            .   ..|.:  ...:.|:..|::..::|.|:|||:  |||...| :.|||||||. ::|.|.  |
  Rat   509 S---DFWDS--LEKASNQPVKEVMDTWTSQMGYPV--VTVSGKQ-NVTQKRFLLDYKADPSQPPS 565

  Fly   539 SLKYT--VPISYTTSETNNFLNTTPKFILKPNVTTTVQFNSTIKWIV------------VNIQQT 589
            :|.||  :||.:|.:..:|.               ||.:.|..:.|.            :|....
  Rat   566 ALGYTWNIPIKWTENGNSNI---------------TVYYRSNREGITLNANLSGDGFLKINPDHI 615

  Fly   590 GYYRVTYSDDNWHAIHHALITANWGGIHENNRAQIVDDLFNLARAGYVTYNLTLDVIEYLQTETN 654
            |:|||.|..:.|..|...| ::|.......:|:..:||.|.||||..:.|...|::..||.:|.:
  Rat   616 GFYRVNYEAETWDWIAETL-SSNHMNFSSADRSSFIDDAFALARAQLLDYEKALNLTRYLTSEKD 679

  Fly   655 YIPWTSAFNGFNYLTIRLGNDTADFNYYIQTLTNKAYNQLGFNEASNDTALDI--YLRTKILSWA 717
            ::||....:..:|: |.:..|..:....|:|........:..:....||...|  .||..:|.:|
  Rat   680 FLPWERVISAVSYI-ISMFEDDRELYPLIETYFRSQVKPIADSLGWQDTGSHITKLLRASVLGFA 743

  Fly   718 CRYGSSDCISQAQGYFQSL----ATVPKNIRATVYCVGLR-EGGEAEFQALYNKFKNETVATEET 777
            |:.|:.:.:..|...|::.    .::|.|:|..||..|:: .|.||.:.....:::..::|.|:.
  Rat   744 CKMGAGEALGNASQLFEAWLKGNESIPVNLRLLVYRYGMQNSGNEAAWNYTLEQYQKTSLAQEKE 808

  Fly   778 LLQNSFGCVKTQSLIEKVFDLIISDE-IRRQDKSSVLATLYTENNENVSPVFALVTQKYEELAEA 841
            .|......||..:|:.:..:::.... |:.||..:|:..: :.|:...|..:..:...::.|...
  Rat   809 KLLYGLASVKDVTLLARYLEMLKDPNIIKTQDVFTVIRYI-SYNSYGKSMAWNWIQLNWDYLVNR 872

  Fly   842 MGGYSAVATVISNIAARFTTNQQLTDLENFNKANGAKFGSSQATLTAAE---ATVKENLEW 899
            ..........|..||..|.|..||..:::|    .||:.::.|.....|   .|||.|:||
  Rat   873 FTINDRYLGRIVTIAEPFNTELQLWQMQSF----FAKYPNAGAGAKPREQVLETVKNNIEW 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31198	NP_732654.1	Peptidase_M1	42..442	CDD:279741	138/414 (33%)
		M1_APN_2	50..510	CDD:189008	151/474 (32%)
		ERAP1_C	582..898	CDD:288671	80/338 (24%)
Enpep	NP_071587.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..77
		Peptidase_M1	84..474	CDD:279741	138/414 (33%)
		M1_APN_2	92..537	CDD:189008	151/474 (32%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q07075	349..353		3/3 (100%)
		ERAP1_C	608..922	CDD:288671	75/320 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.020