Protein Alignment CG31198 and RNPEP

DIOPT Version :9

• Sequence 1: NP_732654.1
• Gene: CG31198 / 318622
• FlyBaseID: FBgn0051198
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: NP_064601.3
• Gene: RNPEP / 6051
• HGNCID: 10078
• Length: 650
• Species: Homo sapiens
• Alignment Length: 518
• Identity: 126/518 - (24%)
• Similarity: 202/518 - (38%)
• Gaps: 111/518 - (21%)

  Fly   180 TQFQTHHARRAFPSFDEPQFKATFDVTLKRHRTFNSVSNTRLISSYPSTEEGIFSDVYKTTPKMS 244
            ||.|....|..||.||.|..|..:...::....|     |.::|:....:.|.....::....:.
Human   168 TQGQAVLNRAFFPCFDTPAVKYKYSALIEVPDGF-----TAVMSASTWEKRGPNKFFFQMCQPIP 227

  Fly   245 TYLLAFIISEFVARKDDDFG----VYARPEYYAQTQYPYNVGIQILEEMGQYLDKDYYSMGNDKM 305
            :||:|..|.:.|:.   :.|    |:|.|......:..||..|:.....|:.|...|.....|.:
Human   228 SYLIALAIGDLVSA---EVGPRSRVWAEPCLIDAAKEEYNGVIEEFLATGEKLFGPYVWGRYDLL 289

  Fly   306 DMAAIPDFSAGAMENWGLLTYRERSLLVDESATTLASRQSIAAVVAHEQAHMWFGDLVTCKWWSY 370
            .|.  |.|..|.||| ..||:....|        ||..:|:|.|:.||.:|.|||:|||...|..
Human   290 FMP--PSFPFGGMEN-PCLTFVTPCL--------LAGDRSLADVIIHEISHSWFGNLVTNANWGE 343

  Fly   371 TWLNEGFARYFQ------YFGTAMVEDKWELEKQFVVDQVQSVMA-----MDSTNATNPLS---- 420
            .||||||..|.|      .||.|           :...:..:..|     ||.|...|||:
Human   344 FWLNEGFTMYAQRRISTILFGAA-----------YTCLEAATGRALLRQHMDITGEENPLNKLRV 397

  Fly   421 -------DENTYTPAHLSRMFNSISYNKGATFIRMIKHTMGEQ-QFQKSLQEYLKKYEYQSSLPE 477
                   .::||         |...|.||..|:..:.|.:|:| ||...|:.|:.:::::|.|.:
Human   398 KIEPGVDPDDTY---------NETPYEKGFCFVSYLAHLVGDQDQFDSFLKAYVHEFKFRSILAD 453

  Fly   478 YLLGAWQANWPNSSYNESSKDI-----FKSFTEQVGYP--LINVTVGNSQVSFTQKRFLLKESDG 535
            ..|..:...:|  ...:...||     |..:....|:|  |.:::.|:|.:...::...|..::.
Human   454 DFLDFYLEYFP--ELKKKRVDIIPGFEFDRWLNTPGWPPYLPDLSPGDSLMKPAEELAQLWAAEE 516

  Fly   536 SDSSLKYTVPIS-YTTSETNNFLN-TTPKFILKPNVTTTVQFNSTIKWIVVNIQQTGYYRVTYSD 598
            .|......|.|| :.|.:...||: ...|..|.|.                |:::.|
Human   517 LDMKAIEAVAISPWKTYQLVYFLDKILQKSPLPPG----------------NVKKLG-------- 557

  Fly   599 DNWHAI---HHALITANWGGI-----HENNRAQIVDDLFNLARAGYV--TYNLTLDVIEYLQT 651
            |.:.:|   .:|.:...||.|     |:.:..::.:.|.|..:..|.  .|:..:...|..||
Human   558 DTYPSISNARNAELRLRWGQIVLKNDHQEDFWKVKEFLHNQGKQKYTLPLYHAMMGGSEVAQT 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31198	NP_732654.1	Peptidase_M1	42..442	CDD:279741	77/287 (27%)
		M1_APN_2	50..510	CDD:189008	95/361 (26%)
		ERAP1_C	582..898	CDD:288671	16/80 (20%)
RNPEP	NP_064601.3	leuko_A4_hydro	24..634	CDD:274120	126/518 (24%)
		M1_LTA4H	24..484	CDD:189006	94/356 (26%)
		Substrate binding. /evidence=ECO:0000250	298..302		2/3 (67%)
		Leuk-A4-hydro_C	504..644	CDD:286244	27/141 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1831
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.760