DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31198 and erap1a

DIOPT Version :9

Sequence 1:	NP_732654.1	Gene:	CG31198 / 318622	FlyBaseID:	FBgn0051198	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	XP_009303348.1	Gene:	erap1a / 564068	ZFINID:	ZDB-GENE-091113-7	Length:	933	Species:	Danio rerio

Alignment Length:	977	Identity:	271/977 - (27%)
Similarity:	465/977 - (47%)	Gaps:	125/977 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LVACVSLASAGTRQLSVDVQPPATLATELNEYRLAEHITPVNYNITLRPYLLETDGNKRFTFDGE 74
            |||......||...::|: :....|....::.||.|.:.|.:|::.:.|.|..      .||.||
Zfish    12 LVALFCALFAGNHAMTVN-KNKTVLPFPWDKMRLPEIVKPQHYDLLIHPNLTS------LTFTGE 69

  Fly    75 VWIEVISNQTTNDIYLHSKNLTYSVREYWQKPTTEVANPTVIQISATNTTNYDTDIVKLTASTAL 139
            |.|::...|.|..|.||||||..|              ..::..|..:..:.|..|.:..|:..:
Zfish    70 VQIQIEVKQDTRAIILHSKNLQVS--------------KALLLGSRQHHHHQDLQISEFEANEQI 120

  Fly   140 T--------ANTTYILHFVYTGLMEDDMHGFYRSSYVDDNNVTKWLGSTQFQTHHARRAFPSFDE 196
            .        ...::::|..:...:.|..||||:..|..::...:.|.||||:..|||.|||.|||
Zfish   121 ALFSEGFTFEKGSHVVHLEFYANLSDSFHGFYKGQYTTNSGEVRMLASTQFEPTHARAAFPCFDE 185

  Fly   197 PQFKATFDVTLKRHRTFNSVSNTRLISSYPSTEEGIFSDVYKTTPKMSTYLLAFIISEF--VARK 259
            |.|||.|.:.::|.....|:||...:.:. ...:||..|.:.|..||||||:||||.:|  :::|
Zfish   186 PAFKANFTIRVRRESRHISISNMPKLRTV-ELADGILEDQFDTMVKMSTYLVAFIICDFHSISKK 249

  Fly   260 DD---DFGVYARPEYYAQTQYPYNVGIQILEEMGQYLDKDYYSMGNDKMDMAAIPDFSAGAMENW 321
            ..   :..||..||..:|.:|..:..:.:|:...:|.|..|   ...|.|:||||||.:||||||
Zfish   250 SQHGVEISVYTVPEKISQAEYALDTAVTMLDFYDEYFDIPY---PLPKHDLAAIPDFQSGAMENW 311

  Fly   322 GLLTYRERSLLVDESATTLASRQSIAAVVAHEQAHMWFGDLVTCKWWSYTWLNEGFARYFQYFGT 386
            ||.||||..||.|...::.:.:..|..|:|||.||.|||:|||.:||:..|||||||::.:|...
Zfish   312 GLSTYRESGLLFDPEKSSSSDKLGITKVIAHELAHQWFGNLVTMQWWNDLWLNEGFAKFMEYVSV 376

  Fly   387 AMVEDKWELEKQFVVDQVQSVMAMDSTNATNPLSD--ENTYTPAHLSRMFNSISYNKGATFIRMI 449
            .:...:.::...| :::..:.:::||.::::|:|.  ||   ||.:|.||:.:||.|||..:.|:
Zfish   377 NITHPELQVNDYF-LEKCFTALSVDSLSSSHPVSTPVEN---PAEISEMFDDVSYRKGACILNML 437

  Fly   450 KHTMGEQQFQKSLQEYLKKYEYQSSLPEYLLGAWQ--------------------------ANWP 488
            :..:..:.|:..:..||||:.||:::..:|   |:                          |..|
Zfish   438 RDFLTPEVFKYGIINYLKKHSYQNTVNSHL---WESLTNICTSDGLDSGRLKLDGFCSKHTAETP 499

  Fly   489 NSS-YNESSKD---IFKSFTEQVGYPLINVTVGNSQVSFTQKRFLLKESDGSDSSLKYTVPISYT 549
            .|. :.|.|.|   |..::|.|.|:|||.|.|...:|:..|:|||......:.||..:.||::|.
Zfish   500 ASKWFKEDSVDVGAIMDTWTLQEGFPLITVEVKGQEVTLKQERFLKGAESSNSSSFLWQVPLTYI 564

  Fly   550 TSETNNFLNTTPKFILKPNVTTTVQFNSTIKWIVVNIQQTGYYRVTYSDDNWHAI------HHAL 608
            ||.:    |...:|:||.. .........::||..|:...|||.|.|....|..:      :|.:
Zfish   565 TSGS----NAVQRFLLKTE-RDVFYLPEKVEWIKFNVDLRGYYIVHYESGGWDCLIKQLRMNHTV 624

  Fly   609 ITANWGGIHENNRAQIVDDLFNLARAGYVTYNLTLDVIEYLQTETNYIPWTSAFNGFNYLT---- 669
            .::       |:||.::.|:|.|.....|..:..|::..||..|:..:|.|   .||:.|.
Zfish   625 FSS-------NDRASLIHDIFQLVSIEKVPLDKALNLSLYLSKESEIMPVT---QGFSELVPLYK 679

  Fly   670 IRLGNDTADFNYYIQTLTNKAYNQLGFNE--ASNDTALDIYLRTKILSWAC--RYGSSDCISQAQ 730
            :....|..:....:::...|.:..|...:  :.|.:..:..||..:|.:||  ||.|  |:|.|.
Zfish   680 LMEKRDMQELENQLKSHLVKLFQPLIDRQSWSDNGSVSERMLRNYLLLFACVRRYPS--CVSTAT 742

  Fly   731 GYFQSLAT------VPKNIRATVYCVGLREGGEAEFQALYNKFKNETVATEETLLQNSFG----C 785
            ..|.....      :|.::...||..|.|.....:|  |..|:|.....:|:.:::.:..    .
Zfish   743 QLFHKWKESDGKMWLPTDVSLVVYTEGARTDDGWDF--LLEKYKRSVSPSEKWMIKAALSYSPLA 805

  Fly   786 VKTQSLIEKVFDLIISDEIRRQDKSSVLATLYTENNENVSPVFALVTQKYEELAEAMG-GYSAVA 849
            .|.|.|:|:..:   .:.::.||..|:|.:: ::|.:.....:..:...:.:|.:... |.||::
Zfish   806 HKLQWLLERSSE---GEIMKTQDLPSMLISV-SKNPKGFKLAWDFLKSNWGKLVKKFDLGSSAIS 866

  Fly   850 TVISNIAARFTTNQQLTDLENFNKANGAKFGSSQATLTAAEATVKENLEWATAKLGVFRSYLANY 914
            .|:..:..:::|.:.|.::|.|..:.....||...::..|...:::|:.|....:.:.:::|.::
Zfish   867 RVVVGVTDQYSTKEMLDEVELFFGSLAQDQGSGLRSIQQALEKIQQNILWMDRNVPLLKAWLDHH 931

  Fly   915 RS 916
            .|
Zfish   932 TS 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31198	NP_732654.1	Peptidase_M1	42..442	CDD:279741	143/414 (35%)
		M1_APN_2	50..510	CDD:189008	162/504 (32%)
		ERAP1_C	582..898	CDD:288671	73/340 (21%)
erap1a	XP_009303348.1	Peptidase_M1	43..430	CDD:279741	143/414 (35%)
		M1_APN_2	52..525	CDD:189008	162/503 (32%)
		ERAP1_C	592..909	CDD:288671	72/334 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I12102
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.920