DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31198 and trhde.2

DIOPT Version :9

Sequence 1:	NP_732654.1	Gene:	CG31198 / 318622	FlyBaseID:	FBgn0051198	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	XP_690889.2	Gene:	trhde.2 / 562409	ZFINID:	ZDB-GENE-070705-89	Length:	994	Species:	Danio rerio

Alignment Length:	929	Identity:	277/929 - (29%)
Similarity:	458/929 - (49%)	Gaps:	104/929 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 SVDVQPPATLATELNEYRLAEHITPVNYNITLRPYLLETDGNKRFTFDGEVWIEVISNQTTNDIY 89
            |.|.|.|      ....||...:.|.:|::.|..::      :.|:|.|||.||.....:|..|.
Zfish    98 SEDGQQP------WRHLRLPATLRPRHYDLRLTVHM------ENFSFSGEVNIEFECVNSTKLIV 150

  Fly    90 LHS------KNLTYSVREYWQKPTTEVANPTVIQISATNTTNYDTDIVKLTA-STALTANTTYIL 147
            |||      |.|.:|        .::.|....||    ...:|....|.:.| ...:....||.:
Zfish   151 LHSDRLELDKVLVFS--------DSKKAGAMRIQ----RRFHYQPKQVYVIALHREMKPLRTYKI 203

  Fly   148 HFVYTGLMEDDMHGFYRSSYVDDNNVTKWLGSTQFQTHHARRAFPSFDEPQFKATFDVTLKRHRT 212
            :..:|..:|.::.||:||||: .|...::|..|||...|||:|||.||||.:||||.|:||...:
Zfish   204 NITFTAHIEHELLGFFRSSYM-LNGERRFLAVTQFSPTHARKAFPCFDEPIYKATFRVSLKHESS 267

  Fly   213 FNSVSNTRLISSYPSTEEGIFSDVYKTTPKMSTYLLAFIISEFVARKD-DDFGV----YARPEYY 272
            :.|:||.. :.:..|.|:|..::.:..||:||||.||:.:..|..::. .|.||    ||||:..
Zfish   268 YQSLSNMP-VEATTSDEDGWVTNHFSRTPRMSTYYLAWAVCNFTYKEAVADNGVLIRLYARPDAI 331

  Fly   273 AQTQYPYNVGIQILEEMGQYLDKDY----YSMGNDKMDMAAIPDFSAGAMENWGLLTYRERSLLV 333
            ......|  .::|.:.:.|:. :||    ||:  .|:|:.|:|.....|||||||..:.|:.:|:
Zfish   332 QSGSGDY--ALRITKRLLQFY-QDYFKVKYSL--PKLDLLAVPKHPYAAMENWGLSVFVEQKILL 391

  Fly   334 DESATTLASRQSIAAVVAHEQAHMWFGDLVTCKWWSYTWLNEGFARYFQYFGTAMVEDKWELEKQ 398
            |...::.:.:..:..||.||..|.|||||||..||...||.||||.||:|.||..:..||.:|||
Zfish   392 DPDVSSFSYQMELTMVVVHEICHQWFGDLVTPVWWEDVWLKEGFAHYFEYIGTDFLFPKWNMEKQ 456

  Fly   399 -FVVDQVQSVMAMDSTNATNPLSDENTYTPAHLSRMFNSISYNKGATFIRMIKHTMGEQQFQKSL 462
             |:.|.:..||.:|...:::|:| :..:....:.|:|:.|:|.|||..|||:.:.||:..||::|
Zfish   457 RFLTDVLHEVMLLDGLASSHPIS-QQVFEATDIDRVFDWIAYKKGAALIRMLANVMGQTLFQRAL 520

  Fly   463 QEYLKKYEYQSSLPEYLLGAWQANWPNSSYNESSKDI-----FKSFTEQVGYPLINVTVGNS--- 519
            .:||..:.|.::..:.|   |  |..:.:.....|||     ...:|.|:|||::.::..:|
Zfish   521 NDYLMTHMYGNAARDDL---W--NKLSEAMQREGKDINITQVMDRWTLQMGYPVVTISKNDSLDN 580

  Fly   520 QVSFTQKRFL------LKESDGSDSSLKYTVPISYTTSETNNFLNTTPKFILKPNVTTTVQFNST 578
            .::.:|:.|:      ::..:..:.|.::.:|::......::....|..::...:....|.....
Zfish   581 SITISQEHFVYDTDAKIQNPELFNKSFQWQIPLTLAVGNASHISTETIIWVTNKSEAHRVGHVVG 645

  Fly   579 IKWIVVNIQQTGYYRVTYSDDNWHAIHHALITANWGGIHENNRAQIVDDLFNLARAGYVTYNLTL 643
            ..|::.||.||||:||.|...||..:...| |.|...|...|||.::||:||||||||:..|:.|
Zfish   646 ETWLLGNINQTGYFRVNYDLHNWKLLIQQL-TRNPTIISVGNRAGLIDDVFNLARAGYLPQNVPL 709

  Fly   644 DVIEYLQTETNYIPWTSAFNGFNYLTIRLGNDTAD---FNYYIQTLTNKAYNQLGFNEASNDTAL 705
            .:|.||..||.::||.:|.... |...:|.:.|.|   |:.|:.......|::||:...|.|.:|
Zfish   710 QMISYLSQETEFLPWHAASRAL-YQLDKLLDRTLDHSLFSDYVLRQVEPKYHKLGWPATSPDGSL 773

  Fly   706 --DIY----LRTKILSWACRYGSSDCISQAQGYFQSLAT-----VPKNIRATVYCVGLREGGEAE 759
              ..|    |:.:::..||.:|:..|..||........:     :|.|:|..|||.|:....|..
Zfish   774 MHSAYQTEELQREVIMLACSFGNKHCHRQAVSLISDWISSNKNRIPPNVRDIVYCTGVSLMDEDV 838

  Fly   760 FQALYNKFKNETVATEETLLQNSFGCVKTQSLIEKVFDL-IISDEIRRQDKSSVLATLYTENNEN 823
            ::.::.||.:.|..:|:.:|..:..|.....|:.::.:| :.||.:..||...|:  ::...|
Zfish   839 WEFIWMKFHSSTAVSEKKVLLEALTCSDNIFLLNRLLNLSLTSDLVPDQDVIDVI--IHVARN-- 899

  Fly   824 VSPV-----FALVTQKYEELAEAMGGYSAV---ATVISNIAARFTTNQQLTDLENFNKANGAKFG 880
              |:     :....:|::.|....|  .|:   :.:||.:.....|..:|.:|:.|...:|   |
Zfish   900 --PLGRHLAWRYFREKWDILNSRYG--EALFMNSKLISGVTEFLNTEAELNELKEFILTSG---G 957

  Fly   881 SSQATLTAAEATVKENLEW 899
            .|......|...|:.|::|
Zfish   958 ESAPAFARAVEIVQANVKW 976

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31198	NP_732654.1	Peptidase_M1	42..442	CDD:279741	142/416 (34%)
		M1_APN_2	50..510	CDD:189008	162/481 (34%)
		ERAP1_C	582..898	CDD:288671	97/338 (29%)
trhde.2	XP_690889.2	Peptidase_M1	109..500	CDD:279741	142/416 (34%)
		M1_APN_2	118..568	CDD:189008	162/480 (34%)
		ERAP1_C	649..968	CDD:288671	95/331 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.010