DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31198 and ERAP1

DIOPT Version :9

Sequence 1:	NP_732654.1	Gene:	CG31198 / 318622	FlyBaseID:	FBgn0051198	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	XP_005272072.1	Gene:	ERAP1 / 51752	HGNCID:	18173	Length:	951	Species:	Homo sapiens

Alignment Length:	968	Identity:	281/968 - (29%)
Similarity:	480/968 - (49%)	Gaps:	109/968 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VAVLLVACVSLASAGTRQ--LSVDVQPPATLATEL--NEYRLAEHITPVNYNITLRPYLLETDGN 66
            ::.||.:.::|.:..|..  .|.:..|..:..|..  |:.||.|::.||:|::.:...|
Human    13 MSFLLSSLLALLTVSTPSWCQSTEASPKRSDGTPFPWNKIRLPEYVIPVHYDLLIHANL------ 71

  Fly    67 KRFTFDGEVWIEVISNQTTNDIYLHSKNLTYSVREYWQKPTTEVANPTVIQISATNTTNYDTDIV 131
            ...||.|...:|:.::|.|:.|.|||.:|..| |...:|...|..:...:|:    ..:...:.:
Human    72 TTLTFWGTTKVEITASQPTSTIILHSHHLQIS-RATLRKGAGERLSEEPLQV----LEHPRQEQI 131

  Fly   132 KLTASTALTANTTYILHFVYTGLMEDDMHGFYRSSYVDDNNVTKWLGSTQFQTHHARRAFPSFDE 196
            .|.|...|.....|.:...|.|.:.:..||||:|:|.......:.|.||||:...||.|||.|||
Human   132 ALLAPEPLLVGLPYTVVIHYAGNLSETFHGFYKSTYRTKEGELRILASTQFEPTAARMAFPCFDE 196

  Fly   197 PQFKATFDVTLKRHRTFNSVSNTRLISSYPSTEEGIFSDVYKTTPKMSTYLLAFIISEF-----V 256
            |.|||:|.:.::|.....::||..|:.|. :..||:..|.:..|.||||||:|||||:|     :
Human   197 PAFKASFSIKIRREPRHLAISNMPLVKSV-TVAEGLIEDHFDVTVKMSTYLVAFIISDFESVSKI 260

  Fly   257 ARKDDDFGVYARPEYYAQTQYPYNVGIQILEEMGQYLDKDYYSMGN--DKMDMAAIPDFSAGAME 319
            .:......|||.|:...|..|..:..:.:||     ..:||:|:..  .|.|:||||||.:||||
Human   261 TKSGVKVSVYAVPDKINQADYALDAAVTLLE-----FYEDYFSIPYPLPKQDLAAIPDFQSGAME 320

  Fly   320 NWGLLTYRERSLLVDESATTLASRQSIAAVVAHEQAHMWFGDLVTCKWWSYTWLNEGFARYFQYF 384
            ||||.||||.:||.|...::.:|:..|...||||.||.|||:|||.:||:..|||||||::.::.
Human   321 NWGLTTYRESALLFDAEKSSASSKLGITMTVAHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEFV 385

  Fly   385 GTAMVEDKWELEKQFVVDQVQSVMAMDSTNATNPLSD--ENTYTPAHLSRMFNSISYNKGATFIR 447
            ..::...:.::...| ..:....|.:|:.|:::|:|.  ||   ||.:..||:.:||:|||..:.
Human   386 SVSVTHPELKVGDYF-FGKCFDAMEVDALNSSHPVSTPVEN---PAQIREMFDDVSYDKGACILN 446

  Fly   448 MIKHTMGEQQFQKSLQEYLKKYEYQSSLPEYLLGAWQANWP------------NSSYNESS---- 496
            |::..:....|:..:.:||:|:.|:::..|.|..:..:..|            .|.::.||
Human   447 MLREYLSADAFKSGIVQYLQKHSYKNTKNEDLWDSMASICPTDGVKGMDGFCSRSQHSSSSSHWH 511

  Fly   497 ------KDIFKSFTEQVGYPLINVTVGNSQVSFTQKRFLLKESDGS-DSSLKYTVPISYTTSETN 554
                  |.:..::|.|.|:|||.:||....|...|:.: :|.|||: |:...:.||:::.||::
Human   512 QEGVDVKTMMNTWTLQKGFPLITITVRGRNVHMKQEHY-MKGSDGAPDTGYLWHVPLTFITSKS- 574

  Fly   555 NFLNTTPKFILKPNVTTTVQFNSTIKWIVVNIQQTGYYRVTYSDDNWHAIHHALITANWGGIHEN 619
               :...:|:||.. |..:.....::||..|:...|||.|.|.||.|.:: ..|:......:..|
Human   575 ---DMVHRFLLKTK-TDVLILPEEVEWIKFNVGMNGYYIVHYEDDGWDSL-TGLLKGTHTAVSSN 634

  Fly   620 NRAQIVDDLFNLARAGYVTYNLTLDVIEYLQTETNYIPWTSAFNGFNYL--TIRLGNDTADFN-- 680
            :||.::::.|.|...|.::....||:..||:.||..:|   .|.|.|.|  ..:| .:..|.|
Human   635 DRASLINNAFQLVSIGKLSIEKALDLSLYLKHETEIMP---VFQGLNELIPMYKL-MEKRDMNEV 695

  Fly   681 ------YYIQTLTNKAYNQLGFNEASNDTALDIYLRTKILSWACRYGSSDCISQAQGYFQSL--- 736
                  :.|:.|.:....|...:|.|....:   ||:::|..||.:....|:.:|:|||:..
Human   696 ETQFKAFLIRLLRDLIDKQTWTDEGSVSERM---LRSQLLLLACVHNYQPCVQRAEGYFRKWKES 757

  Fly   737 ---ATVPKNIRATVYCVGLREGGEAEFQALYNKFKNETVATEETLLQNSFGCVKTQS------LI 792
               .::|.::...|:.||.:.....:|  ||:|::....:||::  |..|...:||:      |:
Human   758 NGNLSLPVDVTLAVFAVGAQSTEGWDF--LYSKYQFSLSSTEKS--QIEFALCRTQNKEKLQWLL 818

  Fly   793 EKVFDLIISDEIRRQDKSSVLATLYTENNENVSPVFALVTQKYEELAEAMG-GYSAVATVISNIA 856
            ::.|.   .|:|:.|:...:| ||...|.......:..:.:.:.:|.:... |.|::|.::....
Human   819 DESFK---GDKIKTQEFPQIL-TLIGRNPVGYPLAWQFLRKNWNKLVQKFELGSSSIAHMVMGTT 879

  Fly   857 ARFTTNQQLTDLENF---NKANGAKFGSSQATLTAAEATVKENLEWATAKLGVFRSYL 911
            .:|:|..:|.:::.|   .|.||::....|.|:    .|::||:.|........|.:|
Human   880 NQFSTRTRLEEVKGFFSSLKENGSQLRCVQQTI----ETIEENIGWMDKNFDKIRVWL 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31198	NP_732654.1	Peptidase_M1	42..442	CDD:279741	145/408 (36%)
		M1_APN_2	50..510	CDD:189008	160/490 (33%)
		ERAP1_C	582..898	CDD:288671	85/341 (25%)
ERAP1	XP_005272072.1	M1_APN_2	61..531	CDD:189008	160/490 (33%)
ERAP1	XP_005272072.1	ERAP1_C	597..916	CDD:314669	84/338 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920