DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31198 and Lvrn

DIOPT Version :9

Sequence 1:	NP_732654.1	Gene:	CG31198 / 318622	FlyBaseID:	FBgn0051198	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	XP_038953134.1	Gene:	Lvrn / 502160	RGDID:	1562779	Length:	993	Species:	Rattus norvegicus

Alignment Length:	1028	Identity:	255/1028 - (24%)
Similarity:	424/1028 - (41%)	Gaps:	212/1028 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFAPRVAVLLVACVSLAS-----AGTRQLSVD--------VQPP-------------ATLATE-- 37
            :.|...||||:|.|.||:     |..:...:|        :.||             :|:.|.
  Rat    18 LLAGLTAVLLLALVVLAALYGSCAHVQSSELDSHLVKDTSLSPPGGQEWTQPTPAHESTVGTSQD 82

  Fly    38 -------LNEYRLAEHITPVNYNITLRPYL----LETDGNKRFTFDGEVWIEVISNQTTNDIYLH 91
                   .:..||...:.|::|::.|.|.|    |.|..   .||.|.|.|.|.....|:.:.||
  Rat    83 WRPPSGPWDHLRLPPWLVPLHYDLELWPRLQPDNLSTPS---LTFTGRVNITVRCTVATSTLLLH 144

  Fly    92 SKNLTYSVREYWQKPTTEVANPTVIQISATNT-TNYDTDIVKLTASTALTANTTYILHFVYTG-L 154
            |..|.|...|.|.....:..|.||.::...|. ...|...|.|....:|...::|.|:|.::| :
  Rat   145 SFFLNYKQVEVWGPLAPDTRNATVGRVPLENVWFALDMQYVVLDLGQSLDPGSSYELNFDFSGQV 209

  Fly   155 MEDDMHGFYRSSYVDDNNVTKWLGSTQFQTHHARRAFPSFDEPQFKATFDVTLKRHRTFNSVSNT 219
            :::...|.:.:.|.|::.: :.|.:||.:...||..||.||||..||||::|:..|..:.::||
  Rat   210 LQEGSEGLFLNLYTDEDQL-RALIATQMEPTFARHVFPCFDEPALKATFNITIIHHPGYVALSN- 272

  Fly   220 RLISSYPSTEEGIFSDV---------YKTTPKMSTYLLAFIISEF--------------VARKDD 261
                 .|...:....||         :.|||:|.|||:|.:|.:|              .|||||
  Rat   273 -----MPQLGQSHRIDVNGSRWTVTSFHTTPRMPTYLVALVICDFDYVSRTERGKEIRVWARKDD 332

  Fly   262 ------DFGVYARPEYYAQTQYPYNVGIQILEEMGQYLDKDYYSMGNDKMDMAAIPDFSAGAMEN 320
                  ||........::..:..:|:...:                 .|.|:.|:|.|..|||||
  Rat   333 IADGYLDFAANHTGPVFSFLEDLFNISYPL-----------------PKTDIIALPTFVNGAMEN 380

  Fly   321 WGLLTYRERSLLVDESATTLASRQSIAAVVAHEQAHMWFGDLVTCKWWSYTWLNEGFARYFQYFG 385
            |||:.: :.|||::........|..|.::::||..|.|||:|||..||:..|||||||.||:...
  Rat   381 WGLMIF-DASLLLELDDDLPEKRAMILSILSHEVGHQWFGNLVTMSWWNNIWLNEGFASYFEVGL 444

  Fly   386 TAMVEDKWELEKQFVVDQVQSVM----AMDSTNATNPLSDENTYTPAHLSRMFNSISYNKGATFI 446
            |.....|......|.:..:..::    :::|...:.|:  ||......::|:|:..:|.|||...
  Rat   445 TNYFYPKVPRNMIFFLTVLHDILEDDHSLESRAVSTPV--ENFTETREINRLFDIYTYKKGACMA 507

  Fly   447 RMIKHTMGEQQFQKSLQEYLKKYEYQSSLPEYLLGAWQANWPN--SSYNESS--------KDIFK 501
            .|:...:.:..|..:|:.||:.:.|.::..:.|       |.:  .:.:|.|        |.|..
  Rat   508 WMLAGFLSQHLFINALKSYLETFSYSNAEQDDL-------WRHIQMAIDEQSIIHLPATVKRIMD 565

  Fly   502 SFTEQVGYPLINVTVGNSQVSFTQKRFLLKESDGSDSSLKYTVPISYTTSETNNFLNTTPKFILK 566
            |:|.|.|:|:|.:......|.  |:.|.|:..:            :.|....|.::  .|.|.:|
  Rat   566 SWTHQSGFPVITLNASTGVVK--QEPFYLERVE------------NQTLLSHNTWI--VPIFWMK 614

  Fly   567 PNVTTTVQF--------------NSTIKWIVVNIQQTGYYRVTYSDDNWHAIHHALITANWGGIH 617
            ..:|..:.:              :|...|:::|...||||||.|....|..::..| ..:...|.
  Rat   615 NGITQPLVWLDKSSMIFPGMKLSDSDSDWVILNFNVTGYYRVNYDKLGWKKLNQQL-EKDPKAIP 678

  Fly   618 ENNRAQIVDDLFNLARAGYVTYNLTLDVIEYLQTETNYIPWTSAFNGFNYLTIRLGNDTADF--- 679
            ..||.|:|.|.|.|::..|:.....||:.:|:..|...:.|      |..| :.|.|....:
  Rat   679 VINRLQLVSDAFALSKNNYIEIETALDLTKYIAKEDEILVW------FEVL-VNLINREVVYDVK 736

  Fly   680 NYYIQTLTNKAYNQ------------LGFNEAS-NDTALDIYLRTKILSWACRYGSSDCISQAQG 731
            |||:..|..|.:.:            :..|.|| .|..|.:....|....||..|..||:..::.
  Rat   737 NYYLYPLLKKYFLKRLNSIWTIYSAIIRENMASLQDNFLSLLPLKKFFETACWLGLEDCLQLSRE 801

  Fly   732 YFQSL-----ATVPKNIRATVYCVGLREGGEAEFQALYNKFKNETVATEETL-LQNSFGCVKTQS 790
            .|:..     ..:|..|...|.|..:..|...::..|:|.:.|:|...|:.. |.::.||.|...
  Rat   802 LFRKWMAHPETAIPPQIEKVVLCNAIALGSNKDWDFLFNLYINKTEEQEDLFHLVHAMGCSKDPR 866

  Fly   791 LIEKVFDLIISDEIRRQDKSSVLATLYTENNENVSPVFALVTQKYEELAEA-MGGYSAVATVISN 854
            .:.:..:..|          :|..:.:.|.|        |:    |.:||: :|.|.|...:|:|
  Rat   867 TLNRFMEYDI----------TVFPSRFNETN--------LI----EVVAESEVGRYVAKDFLINN 909

  Fly   855 IAARFTTNQQLTDLENFNKANGAKFGSSQATLTA-AEATVKENLEWATAKLGV 906
            ..|.:.:......|:.:       |.|...|:.. :...::|:.:..:|..||
  Rat   910 WVAVYESPSLSPLLQQY-------FVSVWTTIAEHSSVHLREDCQHRSAGYGV 955

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31198	NP_732654.1	Peptidase_M1	42..442	CDD:279741	126/438 (29%)
		M1_APN_2	50..510	CDD:189008	142/508 (28%)
		ERAP1_C	582..898	CDD:288671	78/339 (23%)
Lvrn	XP_038953134.1	M1_APN-Q_like	102..569	CDD:341064	139/503 (28%)
Lvrn	XP_038953134.1	ERAP1_C	643..915	CDD:403137	74/301 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020