DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31198 and CG46339

DIOPT Version :9

Sequence 1:	NP_732654.1	Gene:	CG31198 / 318622	FlyBaseID:	FBgn0051198	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_001263001.1	Gene:	CG46339 / 44359	FlyBaseID:	FBgn0285963	Length:	1194	Species:	Drosophila melanogaster

Alignment Length:	993	Identity:	264/993 - (26%)
Similarity:	454/993 - (45%)	Gaps:	158/993 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 VDVQPPATLATELN-------EYRLAEHITPVNYNITLRPYLLETDGNKRFTFDGEVWIEV---I 80
            :.|..||....|.|       ..:|.|...|::|::.:.|.:..:..|      |.:.||:   :
  Fly   266 IPVVEPAAGEVEDNTTKPINRPLKLYEGWRPLHYSLLIEPSVATSISN------GSLTIEIERDV 324

  Fly    81 SNQTT-NDIYLHSKNLTYSVREYWQKPTTEVANPTVIQISATNTTN--------YDTD------- 129
            |..|: ..|.|...|::             ::|..||:..|...:|        :|:|
  Fly   325 SKVTSWEPIVLDVHNVS-------------ISNVRVIRALADGASNASEEQDLDFDSDYGEDNAT 376

  Fly   130 -IVKLTASTALTANTTYILHFVYTGLMEDDMHGFYRSSYVD-DNNVTKWLGSTQFQTHHARRAFP 192
             ::.|:.:.|:......:|...:...:.|.:.|.|::||.: |....:|:.||||....||||||
  Fly   377 FVINLSKTLAVETQLRVLLSLDFVSQVTDTLQGIYKTSYTNPDTKNEEWMISTQFSPVDARRAFP 441

  Fly   193 SFDEPQFKATFDVTLKRHRTFNSVSNTRLISSYPST-----EEGIFSDVYKTTPKMSTYLLAFII 252
            .||.|..||.|.:::.|...|...     :|:.|.:     ..|...|.::|||||.|||:|||:
  Fly   442 CFDRPDMKANFSISIVRPMQFKMA-----LSNMPKSGSRRFRRGFIRDDFETTPKMPTYLVAFIV 501

  Fly   253 SEFVARK--DDDFG------VYARPEYYAQTQYPYNVGIQILEEMGQYLDKDYYSMGN--DKMDM 307
            |..|..:  ..|.|      ::.||::...|.|.|.:   :.:.:..|  :|::.:.|  .|:|:
  Fly   502 SNMVDSRLASQDSGLTPRVEIWTRPQFVGMTHYAYKM---VRKFLPYY--EDFFGIKNKLPKIDL 561

  Fly   308 AAIPDFSAGAMENWGLLTYRERSLLVDES---ATTLASRQSIAAVVAHEQAHMWFGDLVTCKWWS 369
            .::|||...|||||||:|:|:.:|||.|.   |::....|.:|.::|||.||.|||:|||.|||.
  Fly   562 VSVPDFGFAAMENWGLITFRDSALLVPEDLQLASSSEHMQVVAGIIAHELAHQWFGNLVTPKWWD 626

  Fly   370 YTWLNEGFARYFQYFGTAMVEDKWELEKQFVVDQVQSVMAMDSTNATNPLSDENTYTPAHLSRMF 434
            ..||.||||.|..|........:::......:.:.:..|..|:.|.::.:|.:...| ..:.|:|
  Fly   627 DLWLKEGFACYMSYKALEHAHPEFQSMDTLTMLEFKESMEHDADNTSHAISFDVRST-NDVRRIF 690

  Fly   435 NSISYNKGATFIRMIKHTMGEQQFQKSLQEYLKKYEY------------------QSSLPEYLLG 481
            :.|||:||...:||:...:|:..|:.:.::.|||:.|                  |.:||:.|
  Fly   691 DPISYSKGTILLRMLNSIVGDVAFRSATRDLLKKFAYGNMDRDDLWAMLTRHGHEQGTLPKDL-- 753

  Fly   482 AWQANWPNSSYNESSKDIFKSFTEQVGYPLINVTVGNSQVSFTQKRFLLKESDGSDSSLKYTVPI 546
                         |.|.|..|:..|.|||::||....:.:...|:|:||...:.:|.| .:.:||
  Fly   754 -------------SVKQIMDSWITQPGYPVVNVERRGADLVLRQERYLLPSKNTADQS-TWFIPI 804

  Fly   547 SYTTSE--------TNNFLNTTPKFILKPNVTTTVQFNSTIKWIVVNIQQTGYYRVTYSDDNWHA 603
            ::.|.|        |:...:...:.::..||......:..:  |.:|:.:.|||||.|...:|.|
  Fly   805 TFETDELRKGDNIPTHWMRSEDEEELIVGNVFAHSSNSDNV--IYLNLNRQGYYRVNYDMTSWLA 867

  Fly   604 IHHALITANWGGIHENNRAQIVDDLFNLARAGYVTYNLTLD-VIEYLQTETNYIPWTSAFNGFNY 667
                 :..|:..:....|||::||..:|::|.|:||::.|. ::|......:.:.|.:|..|.||
  Fly   868 -----LKKNFSTLPRITRAQLLDDALHLSQAEYLTYDIPLTFLMELFDAVDDELLWIAAKPGLNY 927

  Fly   668 LTIRLGNDTA--DFNYYIQTLTNKAYNQLGFNEASNDTALDIYLRTKILSWACRYGSSDCISQAQ 730
            |...|..:.|  .|..:::.:...|::..|.:|..|::.|.:..|..:..:||::....|..:||
  Fly   928 LIYNLKREPAYETFRAFMKFIVRPAFDHYGLHEPDNESHLQLKHRALVAYFACKFNYDRCTQKAQ 992

  Fly   731 GYFQSLATVPK------NIRATVYCVGLREGGEAEFQALYNKFKNETVATEETLLQNSFGCVKTQ 789
            ..|:.....||      |:::.:||..|.||...|:...|.::|..|.|:|:..:..|.||....
  Fly   993 MKFREWMRDPKNNPIKPNLKSVIYCTSLAEGSSPEWYFAYKQYKTTTSASEKEEILTSLGCTTKP 1057

  Fly   790 SLIEKVFDLII--SDEIRRQDKSSVLATLYTENNENVSPVFALVTQKYEELAEAMG-GYSAVATV 851
            .|:.|..::.|  :..|.:||.:.....: ..|.......|..:....:|:.|..| |:|.::.:
  Fly  1058 WLLSKYLNMTINPTSGILKQDGALAFRAV-ASNAIGHEIAFDFLQGNIKEIVEYYGDGFSTLSEM 1121

  Fly   852 ISNIAARFTTN---QQLTDLENFNKANGAKFG--SSQATLTAAEATVKENLEWATAKLGVFRSY- 910
            |.::......:   .||.||    .|...|.|  :.::.:..|...|..|:.|.:      .||
  Fly  1122 IKSLTIYMNKDYHKHQLLDL----AATCRKLGLHAVESAIELALEQVNNNIYWRS------HSYH 1176

  Fly   911 -LANYRSG---SAMVNAF 924
             |.|:..|   ...:|.|
  Fly  1177 SLKNFLEGIVSEFQINIF 1194

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31198	NP_732654.1	Peptidase_M1	42..442	CDD:279741	129/438 (29%)
		M1_APN_2	50..510	CDD:189008	146/516 (28%)
		ERAP1_C	582..898	CDD:288671	85/332 (26%)
CG46339	NP_001263001.1	Peptidase_M1	296..698	CDD:279741	127/431 (29%)
		M1_APN_2	297..769	CDD:189008	146/516 (28%)
		ERAP1_C	846..1138	CDD:288671	75/297 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	6	6.020