DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31198 and rnpep

DIOPT Version :9

Sequence 1:	NP_732654.1	Gene:	CG31198 / 318622	FlyBaseID:	FBgn0051198	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_001002741.1	Gene:	rnpep / 437014	ZFINID:	ZDB-GENE-040718-241	Length:	626	Species:	Danio rerio

Alignment Length:	693	Identity:	153/693 - (22%)
Similarity:	260/693 - (37%)	Gaps:	153/693 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 TRQLSVDVQPPATLATELNEYRLAEHITPVNYNITLRPYLLETDGNKRFTFDGEVWIEVISNQTT 85
            |..|..|.......::...:::: ||     :::.|:...|:.      :..|...||:...|.:
Zfish     6 TLTLYSDKAEDVATSSSFRQFKI-EH-----FHLDLKVDFLQK------SISGTETIELQCIQDS 58

  Fly    86 N-----DIY----LHSKNLTYSVREYWQKPTTEVANPTVIQISATNTTNYDTDIVKLTASTALTA 141
            .     ||:    :|...|:.:.|::           |..:....:.|:|.|.:: :...||.::
Zfish    59 QSELQLDIHPSLSVHEITLSQNARDW-----------TRTEFLTQDFTSYGTTLL-VKFPTAFSS 111

  Fly   142 NTTYILHFVYTGL-------MEDDMHGFYRSSYVDDNNVTKWLGSTQFQTHHARRAFPSFDEPQF 199
            :....|...||..       :|.:........||          .||.|....|..||.||.|..
Zfish   112 DDKLQLAIRYTATDGPGVCWLEPEQTAGKLKPYV----------FTQGQAVLNRSCFPCFDTPAV 166

  Fly   200 KATFDVTLKRHRTFNSVSNTRLISSYPSTEEGIFSDVYKTTPKMSTYLLAFIISEFVARKDDDFG 264
            |:|:...::....|.:|.:........:  :|.|  ::.....:..||:|..:.:.   :..:.|
Zfish   167 KSTYSAAVQVPDGFTAVMSANKWEQRKA--DGAF--LFTMEHPIPAYLVALAVGDL---QSAEVG 224

  Fly   265 ----VYARPEYYAQTQYPYNVGIQILEEMGQYLDKDYYSMGNDKMDMAAIPDFSAGAMENWGLLT 325
                |:..|......:..|:..|:....:|:.|...|.....|.:.|.  |.|..|.||| ..||
Zfish   225 PRTRVWTEPCLLQAAKQEYDNVIEDFLSVGEKLFGPYVWGRYDVLFMP--PSFPFGGMEN-PCLT 286

  Fly   326 YRERSLLVDESATTLASRQSIAAVVAHEQAHMWFGDLVTCKWWSYTWLNEGFARYFQ------YF 384
            :....|        ||..:|:|.|:.||..|.|||:|||...|...||||||..|.|      .:
Zfish   287 FVTPCL--------LAGDRSLADVIVHEICHSWFGNLVTNATWGDFWLNEGFTMYAQRRVCRELY 343

  Fly   385 GTAMVEDKWELEKQFVVDQVQSVMAMDSTNATNPLS-----------DENTYTPAHLSRMFNSIS 438
            |.|....:....|..:...      ||:|...:||:           .::||         |...
Zfish   344 GEAYTCLEAATGKALLRQH------MDNTGEDHPLNKLRVKIEPGVDPDDTY---------NETP 393

  Fly   439 YNKGATFIRMIKHTMGEQ-QFQKSLQEYLKKYEYQSSLPEYLLGAWQANWPNSSYNESSK----D 498
            |.||..|:..:.|..|:| :|...|:.|::|::::|.|.|..|..:...:|........|    |
Zfish   394 YEKGFCFVSYLAHLTGDQSRFDTFLKAYVEKFKFRSVLAEDALEFYLEYFPELKERNVHKIEGLD 458

  Fly   499 IFKSFTEQVGYP--LINVTVGNSQVSFTQKRFLLKE---SDGSD-SSLKYTVPISYTTSETNNFL 557
             |.|:....|:|  :.:::.|.:.:...:   ||.|   |...| .|:..|...|:.|.:|..||
Zfish   459 -FDSWLNVPGWPPYVPDLSAGQTLMKPAE---LLAEKWLSHNLDLESICKTDLKSWKTYQTVYFL 519

  Fly   558 N----TTP-------------KFILKPNVTTTVQFNSTIK--W---IVVNIQQTGYYRVT--YSD 598
            :    .:|             ..|:|.|       |:.:|  |   :..|....|:..:.  .|.
Zfish   520 DRILEKSPLPDGNLKKLEECYSQIIKSN-------NAELKVRWAQIVAKNQYSPGFQHIRDFLSS 577

  Fly   599 DNWHAIHHALITANWGGIHENNRAQIVDDLFNLARAGYVTYNL 641
            .........:..|.|.|..|.....|  ::|: |.:|.:..|:
Zfish   578 QGKQKYTLPVYRALWNGSEETKALAI--EMFS-ATSGQLHVNV 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31198	NP_732654.1	Peptidase_M1	42..442	CDD:279741	97/436 (22%)
		M1_APN_2	50..510	CDD:189008	115/501 (23%)
		ERAP1_C	582..898	CDD:288671	12/62 (19%)
rnpep	NP_001002741.1	leuko_A4_hydro	16..623	CDD:274120	150/683 (22%)
		M1_LTA4H	16..464	CDD:189006	116/515 (23%)
		Leuk-A4-hydro_C	484..624	CDD:286244	31/147 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810