DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31198 and CG31233

DIOPT Version :9

Sequence 1:	NP_732654.1	Gene:	CG31198 / 318622	FlyBaseID:	FBgn0051198	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_001303538.1	Gene:	CG31233 / 42557	FlyBaseID:	FBgn0051233	Length:	952	Species:	Drosophila melanogaster

Alignment Length:	965	Identity:	293/965 - (30%)
Similarity:	487/965 - (50%)	Gaps:	61/965 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VLLVACVSLASAGTRQLSV-----DVQPP-----ATLATELNEYRLAEHITPVNYNITLRPYLLE 62
            |||:|..:..:|..||..:     .::.|     ..||.|.| |||.....|.:|.::|...:..
  Fly    14 VLLLAISATQAAVVRQYPILDHLQHLENPMQRLVVPLADEDN-YRLPYDTIPSHYAVSLSTNVHT 77

  Fly    63 TDGNKRFTFDGEVWIEVISNQTTNDIYLHSKNLTYSVREYWQKPTTE-VANPTVIQISATNTTNY 126
            .|    ..|:|.|.|.:....||..|.:|::.|........|:..|| ||...|.:        |
  Fly    78 GD----TVFNGTVAITLSVLNTTTKIVVHARQLENFTASIIQQGVTEAVAQELVYE--------Y 130

  Fly   127 DTDIVKLTAS-TALT--ANTTYILHFVYTGLMEDDMHGFYRSSYVDDNNVTKWLGSTQFQTHHAR 188
            :.:...||.| |.||  .:||:||...|.|.:..|..|||.|:|.|:...||:|.:|||::..||
  Fly   131 EAEREFLTFSKTGLTFPEDTTWILTINYQGHLRTDNGGFYLSTYTDEEGNTKYLATTQFESTDAR 195

  Fly   189 RAFPSFDEPQFKATFDVTLKRHRTFNSVSNTRLISSYPSTEEGIFSDVYKTTPKMSTYLLAFIIS 253
            .|||.:|||..:|.|.:|:|...::|::||..:.||..|   |:  .|::.|..|.:||:|||:|
  Fly   196 HAFPCYDEPSKRAEFTITIKHDPSYNAISNMPVDSSSTS---GV--TVFQKTVNMPSYLVAFIVS 255

  Fly   254 EFVARKDDDFG----VYARPEYYAQTQYPYNVGIQILEEMGQYLDKDYYSMGNDKMDMAAIPDFS 314
            |||..:.:..|    |::|.....:.::....|:.:.:.:..|.|..:   ...|:|.|.||||:
  Fly   256 EFVFSEGELNGLPQRVFSRNGTEHEQEWALTTGMLVEKRLSGYFDVPF---ALPKLDQAGIPDFA 317

  Fly   315 AGAMENWGLLTYRERSLLVDESATTLASRQSIAAVVAHEQAHMWFGDLVTCKWWSYTWLNEGFAR 379
            |||||||||.||||..||.:...:|.:::.:||.:.|||.|||||||||..:|||:.||.||||.
  Fly   318 AGAMENWGLATYREEYLLYNTENSTTSTQTNIATIEAHEDAHMWFGDLVAIEWWSFLWLKEGFAT 382

  Fly   380 YFQYFGTAMVEDKWELEKQFVVDQVQSVMAMDSTNATNPLSDENTYTPAHLSRMFNSISYNKGAT 444
            .|:.....:...:|::.:.|.....||.:..|::....|:| .....|:.::.:::|:||.|..:
  Fly   383 LFENLAVDLAYPEWDIFQTFHAGSYQSALVNDASANARPMS-HFVQKPSEIALLYDSVSYAKAGS 446

  Fly   445 FIRMIKHTMGEQQFQKSLQEYLKKYEYQSSLPEYLLGAWQANWPNSSYNESS--KDIFKSFTEQV 507
            .:.|.:|.:....||:.|..||...::.::.|..|..|........:|...:  .|:..|:|.|.
  Fly   447 VLDMWRHALTNTVFQRGLHNYLVDNQFTAANPSKLFEAIAKAAVEENYEVKATVPDMMGSWTNQG 511

  Fly   508 GYPLINVTVGNSQVSFTQKRFL-LKESDGSDSSLKYTVPISYTTSETNNFLNT-TPKFILKPNVT 570
            |.||:.||......|||.|:.: ..:.|.::..|.| |||:|..|:..:|.|| ...::|..:..
  Fly   512 GVPLLTVTRNYDNGSFTVKQSVYTNDKDYTNDKLWY-VPINYAESKNPDFRNTEATHYLLNQSEI 575

  Fly   571 TTVQFNSTIKWIVVNIQQTGYYRVTYSDDNWHAIHHALITANWGGIHENNRAQIVDDLFNLARAG 635
            |.........|:::|.:.||||||.|...|:..|..||||.. ..|...||||:::||:..|.:|
  Fly   576 TIYSDLDQTNWLILNKKSTGYYRVLYDAQNYQLITSALITRP-HKIDPRNRAQLINDLYRFATSG 639

  Fly   636 YVTYNLTLDVIEYLQTETNYIPWTSAFNGFNYLTIRLGNDT--ADFNYYIQTLTNKAYNQLGFNE 698
            .|.:...|:::.||..|..|.||::.......|...|..|.  .:|.:|::.|.:..:::.|.|:
  Fly   640 RVPHATLLELLTYLPQEDQYSPWSATNTVITLLNRYLSGDADYGNFQFYVRELVSLQFDKFGVND 704

  Fly   699 ASNDTALDIYLRTKILSWACRYGSSDCISQAQGYFQSL----ATVPKNIRATVYCVGLREGGEAE 759
            ...|..|..:.|..:::.||..|..:|:::......:|    ..:..|:::.|||.||::..:..
  Fly   705 NKGDHHLVPFTRNVLINLACLAGLENCLTETTAKLTALVEEGTKIEPNLQSQVYCNGLKQADDKT 769

  Fly   760 FQALYNKFKNETVATEETLLQNSFGCVKTQSLIEK-VFDLIISDEIRRQDKSSVLATLYTENNEN 823
            |..::||..|.|...|..||.::.||.:..:.:|| |:..|..:.:|.|::.:||:.:|:.....
  Fly   770 FDFVFNKLLNSTDQAERRLLISALGCSQNTAQLEKFVYSSIEPEGLRDQERITVLSPVYSRGEVG 834

  Fly   824 VSPVFALVTQKYEELAEAMGGYSAVATVISNIA--ARFTTNQQLTDL--ENFNKANGAKFGSSQA 884
            :......:.:.:|:..:...|:..|..:.|:|.  :.:|.|.:..|.  |..:...|:::..|
  Fly   835 LLVAIEFLQKNWEKYGQLNSGFGGVNPLYSDIVGISAYTVNDKQKDALQELVDTVKGSEYVPS-- 897

  Fly   885 TL-TAAEATVKENLEWATAKLGVFRSYLANYRSGSAMVNAFSAISLLMVALVTML 938
            || .:.::.|..|..|..:......:::|.:||||:.:|| |.:::|...|...|
  Fly   898 TLQDSVDSNVNANYAWLASNRDPLMTWVAGFRSGSSALNA-SILAILACLLAAKL 951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31198	NP_732654.1	Peptidase_M1	42..442	CDD:279741	142/407 (35%)
		M1_APN_2	50..510	CDD:189008	156/469 (33%)
		ERAP1_C	582..898	CDD:288671	87/327 (27%)
CG31233	NP_001303538.1	Peptidase_M1	57..443	CDD:279741	142/406 (35%)
		M1_APN_2	65..514	CDD:189008	156/469 (33%)
		ERAP1_C	587..905	CDD:288671	85/320 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	6	6.010