DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31198 and CG5849

DIOPT Version :9

Sequence 1:	NP_732654.1	Gene:	CG31198 / 318622	FlyBaseID:	FBgn0051198	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_650979.1	Gene:	CG5849 / 42556	FlyBaseID:	FBgn0038897	Length:	968	Species:	Drosophila melanogaster

Alignment Length:	927	Identity:	235/927 - (25%)
Similarity:	402/927 - (43%)	Gaps:	169/927 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFAPRVAVLLVACVSL---ASAGTRQLSVDVQPPATLATELNEYRLAEHITPVNYNITLRPYLLE 62
            |..|...|:::..:.|   .|.|.|:.|:               ||.....|:.|.:.     :.
  Fly     1 MITPPSGVVVLVTLGLLVSGSMGERERSL---------------RLPNATYPLFYQLH-----IS 45

  Fly    63 TDGNK-RFTFDGEVWIEVISNQTTNDIYLHSKNLT---YSVREYWQKPT------TEVANPTVIQ 117
            :|.:| :..|.|...|:|...|:||:|.||:||||   .:|.....:.:      |...:||...
  Fly    46 SDIHKGQLLFSGNATIDVAIRQSTNEIVLHAKNLTDIQITVHRLMAEGSEIVDDLTHTLHPTAAL 110

  Fly   118 ISATNTTNYDTDIVKLTASTALTANTTYILHFVYTGLMEDDMHGFYRSSYVD-DNNVTKWLGSTQ 181
            :......||.          |......|.|..:||.:|.....|.|...|.| :||.|.::.:||
  Fly   111 LIIHPIENYQ----------AFEEGQQYRLEILYTAIMASRPAGLYYMDYRDEENNHTVYVAATQ 165

  Fly   182 FQTHHARRAFPSFDEPQFKATFDVTLKRHRTFNSVSNTRLISSYPSTEEGIFSDV----YKTTPK 242
            .:..:.|..||.:|||.||:.|.:.:....:.:::||      .|..|.....|:    :.|||.
  Fly   166 CEPTYGRLIFPCYDEPGFKSNFSIKITHGSSHSAISN------MPVKEVLAHGDLKTTSFHTTPP 224

  Fly   243 MSTYLLAFIISEFVARKDDDFG----VYARPEYYAQTQYPYNVGIQILEEMGQYLDKDYYSMGN- 302
            :||||:||:||:|.:..:...|    :|..|....:.|......::.:..:     :||:.:..
  Fly   225 ISTYLVAFVISDFGSISETYRGITQSIYTSPTSKEKGQVALKNAVRTVAAL-----EDYFGVSYP 284

  Fly   303 -DKMDMAAIPDFSAGAMENWGLLTYRERSLLVDESATTLASRQSIAAVVA-HEQAHMWFGDLVTC 365
             .|:|..|:......|||||||:||::.:||.:.|:.  ..::.:..:.. ||.||.|||:||:.
  Fly   285 LPKLDHVALKKNYGAAMENWGLITYKDVNLLKNISSD--GQKRKLDLITQNHEIAHQWFGNLVSP 347

  Fly   366 KWWSYTWLNEGFARYFQYFGTAMVEDKWELEKQFVVDQVQSVMAMDSTNATNPLSDENTYTPAH- 429
            :||:|||:|||||.||.|..|.::....::...|:..:..|..:.:|....:|:|.   |....
  Fly   348 EWWTYTWMNEGFATYFSYVITDLIYPNDKMMDMFMTHEADSAYSYNSFFDVHPMSH---YVEGEK 409

  Fly   430 -LSRMFNSISYNKGATFIRMIKHTMGEQQFQKSLQEYLKKYEYQSSLPEYLLGAWQANWPNSSYN 493
             :..:|:.|||.:||..|:|..|...::.|.:.:..:|:||.|..:....|..|..:...:..|.
  Fly   410 DIMGVFDIISYKRGACVIKMFHHAFRQKLFVRGISHFLEKYRYSVANELNLFDALHSELQDDEYF 474

  Fly   494 ESS------KDIFKSFTEQVGYPLINVT--VGNSQVSFTQKRFLLKESDGSDSSLKYTVPISYTT 550
            ...      ::|..|:|.....|::.||  ..|:.::|||:...:|:.       .:.:||::.|
  Fly   475 SHQPWASRIREIMLSWTHSEWLPILVVTRNYENNTITFTQRSVHMKDE-------LWWIPINFAT 532

  Fly   551 SETNNFLNTTPKFILKPNVTTTVQFN------STIKWIVVNIQQTGYYRVTYSDDNWHAIHHALI 609
            :::.||.:|.....:.|....||...      |...||:||.|.||:|.|.|..||..||...|.
  Fly   533 TQSPNFEDTQVDMFMPPQPQYTVSLEDLNIHVSGRDWIMVNKQHTGFYLVRYDTDNLMAIARQLQ 597

  Fly   610 TANWGGIHENNRAQIVDDLFNLARAGYV-TYNLTLDVIEYLQTETNYIPWTSAFNGFNYLTIRLG 673
            | |...||..||..:..||..|.....: ...:..::::||:.|.:.:.|....:....||..|.
  Fly   598 T-NHSVIHPINRLGLFRDLGPLIEHNEIEQVEVVFELLKYLELEEDVLTWNQLQDTIECLTRNLH 661

  Fly   674 NDTAD--FNYYIQTLT----NKAYNQLGFNEASNDTALDIYLRTKILSWACRYGSSDCISQAQGY 732
            ..::.  ||.:::.|.    .:.|.:.|.|.|.:.      :...||..||.....:|:.    |
  Fly   662 GTSSQSLFNEFVRRLVGPTFRRVYVEQGVNLAEDG------MFRGILEIACSADLPECLE----Y 716

  Fly   733 FQSLATVPKNIRATVYCVGLREGGEAEFQALYNKFKNETVATEETLLQNSFGCVKTQSLIEKVFD 797
            .:.||  .::|...:|   .::|  :::.|:.                :|..|:..:.|.::.|.
  Fly   717 TRRLA--KEHIIDKIY---FKDG--SDYHAII----------------DSVLCMGVRYLSDQDFQ 758

  Fly   798 LIISDEIRRQDKSSV---------------------LATLYTENNENVSPVFALVTQKYEELAEA 841
            .|| |.::..|::||                     |..|..||:.:      :|..::|:|...
  Fly   759 RII-DMMQEIDRASVYYDDIIYALRCTQSHRHLLYYLEGLMGENSTH------MVLSEFEDLMYL 816

  Fly   842 MGGYSAVATVISNIAAR 858
            :..|.      ||:|:|
  Fly   817 LYIYK------SNLASR 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31198	NP_732654.1	Peptidase_M1	42..442	CDD:279741	121/423 (29%)
		M1_APN_2	50..510	CDD:189008	134/489 (27%)
		ERAP1_C	582..898	CDD:288671	71/305 (23%)
CG5849	NP_650979.1	Peptidase_M1	30..423	CDD:279741	121/423 (29%)
		M1_APN_2	38..497	CDD:189008	134/489 (27%)
		ERAP1_C	570..>841	CDD:288671	71/305 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	1	0.900	-	-		E1_COG0308
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	7	6.920