DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31198 and npepps

DIOPT Version :9

Sequence 1:	NP_732654.1	Gene:	CG31198 / 318622	FlyBaseID:	FBgn0051198	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_001157499.1	Gene:	npepps / 407726	ZFINID:	ZDB-GENE-060524-3	Length:	872	Species:	Danio rerio

Alignment Length:	913	Identity:	265/913 - (29%)
Similarity:	441/913 - (48%)	Gaps:	100/913 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 RLAEHITPVNYNITLRPYLLETDGNKRFTFDGEVWIEVISNQTTNDIYLHSKNLTYSVREYWQKP 106
            ||...:.||||.:.|:|.|::      |||:|::...|...|.||.|.::..::
Zfish     9 RLPTDVYPVNYGLRLKPDLVD------FTFEGKLEAAVEVTQGTNQIVMNCADI----------- 56

  Fly   107 TTEVANPTVI-----QISAT--NTTNYDTDIVKLTASTALTANTTYILHFVYTGLMEDDMHGFYR 164
              ::...:.:     :|:||  |..|.|..:.....||....:.:..:.||  |.:.|.|.||||
Zfish    57 --DIITASFVPDGGEEINATGFNYQNEDEKVTLCFPSTLQKGSGSLKIDFV--GELNDKMKGFYR 117

  Fly   165 SSYVDDNNVTKWLGSTQFQTHHARRAFPSFDEPQFKATFDVTLKRHRTFNSVSNTRLISSYPSTE 229
            |.|.....| ::...|||:...||||||.:|||..|||||:||...:...::||..::...|..|
Zfish   118 SKYSSSGEV-RYAAVTQFEATDARRAFPCWDEPAIKATFDITLIVPKDRVALSNMNVVDRKPYAE 181

  Fly   230 EGIFSDV-YKTTPKMSTYLLAFIISE--FVARKDDD---FGVYARPEYYAQTQYPYNVGIQILEE 288
            :....:| :.|||.|||||:||:|.|  ||..:..|   ..||.......|.::...|..:.|.
Zfish   182 DQSLVEVKFATTPIMSTYLVAFVIGEYDFVESQSSDGVTVRVYTPVGKAEQGKFALEVATKTLP- 245

  Fly   289 MGQYLDKDYYSMGN--DKMDMAAIPDFSAGAMENWGLLTYRERSLLVDESATTLASRQSIAAVVA 351
                ..|||:|:..  .|:|:.||.||:|||||||||:||||.:||:|...:..:|||.:|.||.
Zfish   246 ----FYKDYFSVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCASSRQWVALVVG 306

  Fly   352 HEQAHMWFGDLVTCKWWSYTWLNEGFARYFQYFGTAMVEDKWELEKQFVVDQVQSVMAMDSTNAT 416
            ||.||.|||:|||.:||::.|||||||.:.:|........::::..|||.......:.:|:.:.:
Zfish   307 HELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRALDLDALDNS 371

  Fly   417 NPLSDENTYTPAHLSRMFNSISYNKGATFIRMIKHTMGEQQFQKSLQEYLKKYEYQSSLPEYLLG 481
            :|: :.:...|:.:..:|::|||:|||:.|||:.:.:|::.|:|.:..||.|::::::..|.|
Zfish   372 HPI-EVDVGHPSEVDEIFDAISYSKGASVIRMLHNYIGDEDFRKGMNAYLLKFQHKNASTEDL-- 433

  Fly   482 AWQANWPNSSYNESSKDI---FKSFTEQVGYPLINVTV---GNSQV-SFTQKRFLLKESDGSDSS 539
             |:.     ....|.|.|   ..|:|:|:|:|:|.|..   |:.:| ..:||:|........:..
Zfish   434 -WEC-----LEQASGKPIAAVMNSWTKQMGFPIIVVDQEQHGSDRVLKISQKKFCASGPRNDEDC 492

  Fly   540 LKYTVPISYTTSETNNFLNTTPKFIL-KPNVTTTVQFNSTIKWIVVNIQQTGYYRVTYSDDNWHA 603
            ..:.||||..|||..:...|  |.:| :|..|..:...:...||.:|....|:||:.||.
Zfish   493 PNWMVPISICTSEDPSCTKT--KILLDQPETTVNITNVAPDHWIKINPGTVGFYRIQYSS----- 550

  Fly   604 IHHALITANWGGIHE-----NNRAQIVDDLFNLARAGYVTYNLTLDVIEYLQTETNYIPWTSAFN 663
               |::.:...||.:     .:|..:.:|||:|||||.::....|.|:|....|.||..|:....
Zfish   551 ---AMLESLLPGIRDLTLLPVDRLGLQNDLFSLARAGMISTVEVLKVMEAFVNEPNYTVWSDLSC 612

  Fly   664 GFNYLTIRLGNDTADFNYYIQTLTNKAYN----QLGFNEASNDTALDIYLRTKILSWACRYGSSD 724
            ....|:..|.:  .||:..||......:.    :||::..:.:..||..||..:|....:.|...
Zfish   613 NLGVLSSLLSH--TDFHEDIQEFIRDLFTPIGMKLGWDSRTGEGHLDALLRGLVLGKLGKAGHKA 675

  Fly   725 CISQAQGYF----QSLATVPKNIRATVYCVGLREGGEAEFQALYNKFKNETVATEETLLQNSFGC 785
            .:.:|:..|    :....:..::|:.||...|:.|.......:....|...:..|:..::...|.
Zfish   676 TLEEARRRFREHVEGKQILSADLRSPVYLTVLKHGDSTTLDTMLKLHKQADMQEEKNRIERVLGA 740

  Fly   786 VKTQSLIEKVFDLIISDEIRRQDKSSVLATLYTENNENVSPVFALVTQKYEELAEAMGGYSAVAT 850
            :....||::|.:..:|:|:|.||..||:..:...:.:.....:..|...:|||.....|...::.
Zfish   741 IPAPDLIQRVLNFALSEEVRPQDTVSVIGGVAGSSKQGRKAAWKFVKDNWEELHNRYQGGFLISR 805

  Fly   851 VISNIAARFTTNQQLTDLENFNKANGAKFGSSQATLTAAEATVKE-------NLEWATAKLGVFR 908
            :|......|..::...::::|.:::.|         .|||.||::       |..|.........
Zfish   806 LIKLTVDGFAIDKMAAEVKSFFESHHA---------PAAERTVQQCCENILLNAAWLKRDADDIH 861

  Fly   909 SYL 911
            .||
Zfish   862 QYL 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31198	NP_732654.1	Peptidase_M1	42..442	CDD:279741	144/414 (35%)
		M1_APN_2	50..510	CDD:189008	163/477 (34%)
		ERAP1_C	582..898	CDD:288671	75/335 (22%)
npepps	NP_001157499.1	Peptidase_M1	9..396	CDD:279741	144/414 (35%)
		M1_APN_2	17..459	CDD:189008	163/477 (34%)
		ERAP1_C	534..845	CDD:288671	74/329 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820