DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31198 and LNPEP

DIOPT Version :9

Sequence 1:	NP_732654.1	Gene:	CG31198 / 318622	FlyBaseID:	FBgn0051198	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_005566.2	Gene:	LNPEP / 4012	HGNCID:	6656	Length:	1025	Species:	Homo sapiens

Alignment Length:	969	Identity:	281/969 - (28%)
Similarity:	436/969 - (44%)	Gaps:	193/969 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 VQPPATLATELN-------EYRLAEHITPVNYNITLRPYLLETDGNKRFTFDGEVWIEVISNQTT 85
            :||.||     |       :.||...:.|:.|.::|.|.|..      .||.|.|.|.|.:.|.|
Human   151 IQPFAT-----NGKLFPWAQIRLPTAVVPLRYELSLHPNLTS------MTFRGSVTISVQALQVT 204

  Fly    86 NDIYLHSKNLTYSVREYWQKPTTEVANPTVIQISATNTTNYDTDI--------VKLTASTALTAN 142
            .:|.|||.....|               .|..:||.::.....:|        :.:.|..||.|.
Human   205 WNIILHSTGHNIS---------------RVTFMSAVSSQEKQAEILEYAYHGQIAIVAPEALLAG 254

  Fly   143 TTYILHFVYTGLMEDDMHGFYRSSYVDDNNVTKWLGSTQFQTHHARRAFPSFDEPQFKATFDVTL 207
            ..|.|...|:..:....:|||..||.|::|..|:..:|||:...||.|||.||||.|||||.:.:
Human   255 HNYTLKIEYSANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKI 319

  Fly   208 KRHRTFNSVSNTRLISSYPSTEEGIFSDVYKTTPKMSTYLLAFIISEFVARKDDDFG----VYAR 268
            .|...:.::||....||. ..::|:..|.:..:.||||||:|||:.|......|..|    :||.
Human   320 IRDEQYTALSNMPKKSSV-VLDDGLVQDEFSESVKMSTYLVAFIVGEMKNLSQDVNGTLVSIYAV 383

  Fly   269 PEYYAQTQYPYNVGIQILEEMGQYLDKDYYSMGNDKMDMAAIPDFSAGAMENWGLLTYRERSLLV 333
            ||...|..|.....:::||....|.:..|   ...|:|:.|||||.|||||||||||:||.:||.
Human   384 PEKIGQVHYALETTVKLLEFFQNYFEIQY---PLKKLDLVAIPDFEAGAMENWGLLTFREETLLY 445

  Fly   334 DESATTLASRQSIAAVVAHEQAHMWFGDLVTCKWWSYTWLNEGFARYFQYFGTAMVEDKWELEKQ 398
            |.:.:::|.|:.:..::|||.||.|||:|||.|||:..|||||||.:.:||         .|||.
Human   446 DSNTSSMADRKLVTKIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYF---------SLEKI 501

  Fly   399 F--------VVDQVQSVMAMDSTNATNPLSDENTYTPAHLSRMFNSISYNKGATFIRMIKHTMGE 455
            |        .:|.....|..||.|:::|:| .:..:...:..||:|:||.||::.:.|:|..:.|
Human   502 FKELSSYEDFLDARFKTMKKDSLNSSHPIS-SSVQSSEQIEEMFDSLSYFKGSSLLLMLKTYLSE 565

  Fly   456 QQFQKSLQEYLKKYEYQSSLPEYLLGAWQANWPNSSYNESS------KDIFKSFTEQVGYPLINV 514
            ..||.::..||..:.|.|...:.|       |  .|:||.:      |.:.|::|.|.|:||:.|
Human   566 DVFQHAVVLYLHNHSYASIQSDDL-------W--DSFNEVTNQTLDVKRMMKTWTLQKGFPLVTV 621

  Fly   515 TVGNSQVSFTQKRFLLK---ESDGSDSSLKYTVPISYTTSETNNFLNTTPKFILKPNVTTTVQFN 576
            .....::...|:||.|.   |...||:|..:.:|:||.| |..|:.......:|... :..:...
Human   622 QKKGKELFIQQERFFLNMKPEIQPSDTSYLWHIPLSYVT-EGRNYSKYQSVSLLDKK-SGVINLT 684

  Fly   577 STIKWIVVNIQQTGYYRVTYSDDNWHAIHHALITANWGGIHENNRAQIVDDLFNLARAGYVTYNL 641
            ..:.|:.|||...|||.|.|:||:|.|:.|.| ..|...:.:.:||.:::::|.||..|.|....
Human   685 EEVLWVKVNINMNGYYIVHYADDDWEALIHQL-KINPYVLSDKDRANLINNIFELAGLGKVPLKR 748

  Fly   642 TLDVIEYLQTETNYIPWTSA-------FN-----GFNYLTIRLGNDTADFNYYIQTLTNKAYNQL 694
            ..|:|.||..|.:..|.|.|       :|     |:..|..||      .....:.|.|:...|.
Human   749 AFDLINYLGNENHTAPITEALFQTDLIYNLLEKLGYMDLASRL------VTRVFKLLQNQIQQQT 807

  Fly   695 GFNEASNDTALDIYLRTKILSWACRYGSSDCISQAQGYF---------QSLATVPKNIRATVYCV 750
            ..:|.:....   .||:.:|.:||.:...:|.:.|...|         |||   |.::..||:.|
Human   808 WTDEGTPSMR---ELRSALLEFACTHNLGNCSTTAMKLFDDWMASNGTQSL---PTDVMTTVFKV 866

  Fly   751 GLRE--------------GGEAEFQALYNKFKNETVATEETLLQNSFGCVKTQSLIEKVFDLIIS 801
            |.:.              |.|||    .||......::|:               :.|::.|:.|
Human   867 GAKTDKGWSFLLGKYISIGSEAE----KNKILEALASSED---------------VRKLYWLMKS 912

  Fly   802 ----DEIRRQDKSSVLATL------------YTENNENVSPVFALVTQKYEELAEAMGGYSAVAT 850
                |..|.|..|.::.|:            :.:.|.|      .:.||:     .:|.|: :..
Human   913 SLNGDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWN------KLVQKF-----PLGSYT-IQN 965

  Fly   851 VISNIAARFTTNQQLTDLENFNKANGAKFGSSQAT-----LTAAEATVKENLEWATAKL 904
            :::.....|:|...|::::.|.:      ..|:||     :..|...::.|::|....|
Human   966 IVAGSTYLFSTKTHLSEVQAFFE------NQSEATFRLRCVQEALEVIQLNIQWMEKNL 1018

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31198	NP_732654.1	Peptidase_M1	42..442	CDD:279741	149/419 (36%)
		M1_APN_2	50..510	CDD:189008	167/485 (34%)
		ERAP1_C	582..898	CDD:288671	85/371 (23%)
LNPEP	NP_005566.2	Dileucine internalization motif. /evidence=ECO:0000255	53..54
		Dileucine internalization motif. /evidence=ECO:0000255	76..77
		Tankyrase binding	96..101
		M1_APN_2	175..617	CDD:189008	167/485 (34%)
		Substrate binding. /evidence=ECO:0000250	428..432		3/3 (100%)
		ERAP1_C	689..1009	CDD:314669	85/369 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920