DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31198 and Lta4h

DIOPT Version :9

Sequence 1:	NP_732654.1	Gene:	CG31198 / 318622	FlyBaseID:	FBgn0051198	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_001025202.1	Gene:	Lta4h / 299732	RGDID:	1311333	Length:	611	Species:	Rattus norvegicus

Alignment Length:	543	Identity:	112/543 - (20%)
Similarity:	210/543 - (38%)	Gaps:	146/543 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 ISNQTTN--DIYLHSKNLTYSVREYWQKPTTEVANPTVIQISATNTTNYDTDIVKLTASTALTAN 142
            :.:|..|  .:.|.:|:||..         ..|.|...::.:...:..|....::::...||:.|
  Rat    43 VQSQEDNLRSLTLDTKDLTIE---------KVVINGQEVKYTLGESQGYKGSPMEISLPIALSKN 98

  Fly   143 TTYILHFVYTGLMEDDMHGFYRSSYVDDNNVTKWLGS------------TQFQTHHARRAFPSFD 195
            ...::..           .|..|   ..::..:||..            :|.|..|.|...|..|
  Rat    99 QEVVIEI-----------SFETS---PKSSALQWLTPEQTSGKQHPYLFSQCQAIHCRAILPCQD 149

  Fly   196 EPQFKATF--DVTLKRHRTFNSVSNTRLISSYPSTEEGIFSD-------VYKTTPK--MSTYLLA 249
            .|..|.|:  :|::.:          .|::...:..:|...|       :|:...:  :..||:|
  Rat   150 TPSVKLTYTAEVSVPK----------ELVALMSAIRDGEAPDPEDPSRKIYRFNQRVPIPCYLIA 204

  Fly   250 FIISEFVARKDDDFG----VYARPEYYAQTQYPYNVG---IQILEEM-GQYLDKDYYSMGNDKMD 306
            .::....:|:   .|    |::..|...::.|.::..   ::|.|:: |.|:...|        |
  Rat   205 LVVGALESRQ---IGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQY--------D 258

  Fly   307 MAAI-PDFSAGAMENWGLLTYRERSLLVDESATTLASRQSIAAVVAHEQAHMWFGDLVTCKWWSY 370
            :..: |.|..|.||| ..||:        .:.|.||..:|::.|:|||.:|.|.|:|||.|.|.:
  Rat   259 LLVLPPSFPYGGMEN-PCLTF--------VTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDH 314

  Fly   371 TWLNEG-------------FARYFQYFGTAMVEDKW-ELE---KQFVVDQVQSVMAMDSTNATNP 418
            .|||||             |...|::|...   ..| ||:   |.|......:.:.:|..:....
  Rat   315 FWLNEGHTVYLERHICGRLFGEKFRHFHAL---GGWGELQNTIKTFGESHPFTKLVVDLKDVDPD 376

  Fly   419 LSDENTYTPAHLSRMFNSISYNKGATFIRMIKHTM-GEQQFQKSLQEYLKKYEYQSSLPEYLLGA 482
            ::             ::||.|.||...:..::..: |.:.|...|:.|::|:.|||...:
  Rat   377 VA-------------YSSIPYEKGFALLFYLEQLLGGPEVFLGFLKAYVEKFSYQSVTTD----- 423

  Fly   483 WQANWPNSSYNESSKDIFKSFTEQVGY-------------PLINVTVGNSQVSFTQKRFLLKESD 534
               :|.:..|......:  ....||.:             |..:||:.|:.::.:|:....||.|
  Rat   424 ---DWKSFLYAHFKDKV--DLLNQVDWNAWLYAPGLPPVKPNYDVTLTNACIALSQRWVTAKEED 483

  Fly   535 GSDSSLKYTVPISYTTSETNNFL 557
            .:..|::....:|  :.:.|.||
  Rat   484 LNSFSIEDLKDLS--SHQLNEFL 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31198	NP_732654.1	Peptidase_M1	42..442	CDD:279741	85/412 (21%)
		M1_APN_2	50..510	CDD:189008	99/494 (20%)
		ERAP1_C	582..898	CDD:288671
Lta4h	NP_001025202.1	leuko_A4_hydro	6..608	CDD:274120	112/543 (21%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P09960	135..137		1/1 (100%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P09960	267..272		1/4 (25%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P09960	564..566
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810