DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31198 and TRHDE

DIOPT Version :9

Sequence 1:	NP_732654.1	Gene:	CG31198 / 318622	FlyBaseID:	FBgn0051198	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_037513.2	Gene:	TRHDE / 29953	HGNCID:	30748	Length:	1069	Species:	Homo sapiens

Alignment Length:	947	Identity:	277/947 - (29%)
Similarity:	466/947 - (49%)	Gaps:	117/947 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LASAGTRQLSVDVQPPATLATE----LNEYRLAEHITPVNYNITLRPYLLETDGNKRFTFDGEVW 76
            :||.||    ...|||:....|    ..:.||:.|:.|::||:.|..::      :.|||.|||.
Human   159 VASPGT----TSAQPPSEEEREPWEPWTQLRLSGHLKPLHYNLMLTAFM------ENFTFSGEVN 213

  Fly    77 IEVISNQTTNDIYLHSKNLTYS--------------VREYWQKPTTEVANPTVIQISATNTTNYD 127
            :|:.....|..:.||:..:...              |..::..|.|:|   .|:.::.|
Human   214 VEIACRNATRYVVLHASRVAVEKVQLAEDRAFGAVPVAGFFLYPQTQV---LVVVLNRT------ 269

  Fly   128 TDIVKLTASTALTANTTYILHFVYTGLMEDDMHGFYRSSYVDDNNVTKWLGSTQFQTHHARRAFP 192
                       |.|...|.|..:|..|:|:::.||:||||| .:...::||.|||...|||:|||
Human   270 -----------LDAQRNYNLKIIYNALIENELLGFFRSSYV-LHGERRFLGVTQFSPTHARKAFP 322

  Fly   193 SFDEPQFKATFDVTLKRHRTFNSVSNTRLISSYPSTEEGIFSDVYKTTPKMSTYLLAFIISEFVA 257
            .||||.:||||.:::|...|:.|:||..:.:|. ..|:|..:|.:..||.||||.||:.|..|..
Human   323 CFDEPIYKATFKISIKHQATYLSLSNMPVETSV-FEEDGWVTDHFSQTPLMSTYYLAWAICNFTY 386

  Fly   258 RK-DDDFGV----YARPEYYAQTQYPYNVGIQILEEMGQYLDKDY----YSMGNDKMDMAAIPDF 313
            |: ....||    ||||:...:....|  .:.|.:.:.::.: ||    ||:  .|:|:.|:|..
Human   387 RETTTKSGVVVRLYARPDAIRRGSGDY--ALHITKRLIEFYE-DYFKVPYSL--PKLDLLAVPKH 446

  Fly   314 SAGAMENWGLLTYRERSLLVDESATTLASRQSIAAVVAHEQAHMWFGDLVTCKWWSYTWLNEGFA 378
            ...|||||||..:.|:.:|:|.|.::::....:..|:.||..|.|||||||..||...||.||||
Human   447 PYAAMENWGLSIFVEQRILLDPSVSSISYLLDVTMVIVHEICHQWFGDLVTPVWWEDVWLKEGFA 511

  Fly   379 RYFQYFGTAMVEDKWELEKQ-FVVDQVQSVMAMDSTNATNPLSDENTYTPAHLSRMFNSISYNKG 442
            .||::.||..:...|.:||| |:.|.:..||.:|...:::|:|.| ......:.|:|:.|:|.||
Human   512 HYFEFVGTDYLYPGWNMEKQRFLTDVLHEVMLLDGLASSHPVSQE-VLQATDIDRVFDWIAYKKG 575

  Fly   443 ATFIRMIKHTMGEQQFQKSLQEYLKKYEYQSSLPEYLLGAW----QANWPNSSYNESSKDIFKSF 503
            |..|||:.:.||...||:.||:||..::|.::....|   |    :|...|..| .:.:::...:
Human   576 AALIRMLANFMGHSVFQRGLQDYLTIHKYGNAARNDL---WNTLSEALKRNGKY-VNIQEVMDQW 636

  Fly   504 TEQVGYPLINV---TVGNSQVSFTQKRFL------LKESDGSDSSLKYTVPISYTTSETNNFLNT 559
            |.|:|||:|.:   |...:::..||:.|:      .|.....::|..:.:|::......::..:.
Human   637 TLQMGYPVITILGNTTAENRIIITQQHFIYDISAKTKALKLQNNSYLWQIPLTIVVGNRSHVSSE 701

  Fly   560 TPKFILKPNVTTTVQFNSTIKWIVVNIQQTGYYRVTYSDDNWHAIHHALITANWGGIHENNRAQI 624
            ...::...:....:.:.....|::.||.||||:||.|...||..:...|| .|...:..:|||.:
Human   702 AIIWVSNKSEHHRITYLDKGSWLLGNINQTGYFRVNYDLRNWRLLIDQLI-RNHEVLSVSNRAGL 765

  Fly   625 VDDLFNLARAGYVTYNLTLDVIEYLQTETNYIPWTSAFNG---FNYLTIRLGNDTADFNYYIQTL 686
            :||.|:||||||:..|:.|::|.||..|.:::||.:|...   .:.|..|:.|... ||.||...
Human   766 IDDAFSLARAGYLPQNIPLEIIRYLSEEKDFLPWHAASRALYPLDKLLDRMENYNI-FNEYILKQ 829

  Fly   687 TNKAYNQLGF--NEASNDTALDIY----LRTKILSWACRYGSSDCISQAQGYFQSLAT-----VP 740
            ....|.:||:  |..:.......|    ||.:::..||.:|:..|..||........:     :|
Human   830 VATTYIKLGWPKNNFNGSLVQASYQHEELRREVIMLACSFGNKHCHQQASTLISDWISSNRNRIP 894

  Fly   741 KNIRATVYCVGLREGGEAEFQALYNKFKNETVATEETLLQNSFGCVKTQSLIEKVFDLIISDEIR 805
            .|:|..|||.|:....|..::.::.||.:.|..:|:.:|..:..|...::|:.::.:|.::.|:
Human   895 LNVRDIVYCTGVSLLDEDVWEFIWMKFHSTTAVSEKKILLEALTCSDDRNLLNRLLNLSLNSEV- 958

  Fly   806 RQDKSSVLATLYTENNENVSPV--------FALVTQKYEELAEAMGGYSAVATVISNIAARFTTN 862
            ..|:.::...::...|.:...:        :.::..:|.| |..|.     :.:||.:.....|.
Human   959 VLDQDAIDVIIHVARNPHGRDLAWKFFRDKWKILNTRYGE-ALFMN-----SKLISGVTEFLNTE 1017

  Fly   863 QQLTDLENFNKANGAKFGSSQATLTAAEATVKENLEW 899
            .:|.:|:||.|...   |.:.|:.:.|..||:.|:.|
Human  1018 GELKELKNFMKNYD---GVAAASFSRAVETVEANVRW 1051

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31198	NP_732654.1	Peptidase_M1	42..442	CDD:279741	142/423 (34%)
		M1_APN_2	50..510	CDD:189008	161/487 (33%)
		ERAP1_C	582..898	CDD:288671	92/337 (27%)
TRHDE	NP_037513.2	M1_APN-Q_like	193..638	CDD:341064	158/482 (33%)
TRHDE	NP_037513.2	ERAP1_C	723..1047	CDD:403137	92/335 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920