DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG31198 and ANPEP

DIOPT Version :9

Sequence 1:NP_732654.1 Gene:CG31198 / 318622 FlyBaseID:FBgn0051198 Length:940 Species:Drosophila melanogaster
Sequence 2:NP_001141.2 Gene:ANPEP / 290 HGNCID:500 Length:967 Species:Homo sapiens


Alignment Length:963 Identity:304/963 - (31%)
Similarity:471/963 - (48%) Gaps:104/963 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 AVLLVACVSLASAGTRQLSVDVQPPATL------------ATEL------NEYRLAEHITPVNYN 53
            ||..:..:|:..:..:..:.:..|.|:.            ||.|      |.|||...:.|.:|.
Human    22 AVCTIIALSVVYSQEKNKNANSSPVASTTPSASATTNPASATTLDQSKAWNRYRLPNTLKPDSYR 86

  Fly    54 ITLRPYLLETDGNKRFTFDGEVWIEVISNQTTNDIYLHSKNLTYSVREYW----------QKP-- 106
            :||||||...| ...:.|.|...:.....:.|:.|.:|||.|.|::.:..          |.|  
Human    87 VTLRPYLTPND-RGLYVFKGSSTVRFTCKEATDVIIIHSKKLNYTLSQGHRVVLRGVGGSQPPDI 150

  Fly   107 -TTEVANPTVIQISATNTTNYDTDIVKLTASTALTANTTYILHFVYTGLMEDDMHGFYRSSYVDD 170
             .||:..||            :..:|.|..|  |..::.|.:...:.|.:.||:.|||||.|: :
Human   151 DKTELVEPT------------EYLVVHLKGS--LVKDSQYEMDSEFEGELADDLAGFYRSEYM-E 200

  Fly   171 NNVTKWLGSTQFQTHHARRAFPSFDEPQFKATFDVTLKRHRTFNSVSNTRLISSYPST---EEGI 232
            .||.|.:.:||.|...||::||.||||..||.|::||...:...::||  ::...|||   |:..
Human   201 GNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTALSN--MLPKGPSTPLPEDPN 263

  Fly   233 FS-DVYKTTPKMSTYLLAFIISEF-VARKDDDFGV----YARPEYYA--QTQYPYNVGIQILEEM 289
            :: ..:.|||||||||||||:||| ...|....||    :|||...|  ...|..||...||...
Human   264 WNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLIRIWARPSAIAAGHGDYALNVTGPILNFF 328

  Fly   290 GQYLDKDYYSMGNDKMDMAAIPDFSAGAMENWGLLTYRERSLLVDESATTLASRQSIAAVVAHEQ 354
            ..:.|..|   ...|.|...:|||:|||||||||:||||.|||.|..:::.::::.:..|:|||.
Human   329 AGHYDTPY---PLPKSDQIGLPDFNAGAMENWGLVTYRENSLLFDPLSSSSSNKERVVTVIAHEL 390

  Fly   355 AHMWFGDLVTCKWWSYTWLNEGFARYFQYFGTAMVEDKWELEKQFVVDQVQSVMAMDSTNATNPL 419
            ||.|||:|||.:||:..|||||||.|.:|.|....|..|.|:...|::.|..|||:|:..:::||
Human   391 AHQWFGNLVTIEWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPL 455

  Fly   420 SD--ENTYTPAHLSRMFNSISYNKGATFIRMIKHTMGEQQFQKSLQEYLKKYEYQSSLPEYLLGA 482
            |.  ....|||.:|.:|::|||:|||:.:||:...:.|..|::.|..||..:.||:::   .|..
Human   456 STPASEINTPAQISELFDAISYSKGASVLRMLSSFLSEDVFKQGLASYLHTFAYQNTI---YLNL 517

  Fly   483 WQ-----ANWPNSSYNESSKDIFKSFTEQVGYPLINVTVGNSQVSFTQKRFLLKESDG----SDS 538
            |.     .|..:.....:.:||...:|.|:|:|:|  ||..|..:.:|:.|||.....    |:.
Human   518 WDHLQEAVNNRSIQLPTTVRDIMNRWTLQMGFPVI--TVDTSTGTLSQEHFLLDPDSNVTRPSEF 580

  Fly   539 SLKYTVPISYTTSETNNFLNTTPKFILKPNVTTTVQFNSTIKWIVVNIQQTGYYRVTYSDDNWHA 603
            :..:.|||    :...:.......:::.......:...|..:|:::|:..||||||.|.::||..
Human   581 NYVWIVPI----TSIRDGRQQQDYWLIDVRAQNDLFSTSGNEWVLLNLNVTGYYRVNYDEENWRK 641

  Fly   604 IHHALITANWGGIHENNRAQIVDDLFNLARAGYVTYNLTLDVIEYLQTETNYIPWTSAFNGFNYL 668
            |...| ..:...|...|||||::|.||||.|..|...|.|:...:|..|..|:||.:|.:..:| 
Human   642 IQTQL-QRDHSAIPVINRAQIINDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLSY- 704

  Fly   669 TIRLGNDTADFNYYIQTLTNKAYNQLGFNEASN--------DTALDIYLRTKILSWACRYGSSDC 725
             .:|..|.::....::....|....|..:..:|        :..:|.|.....:|.||..|..:|
Human   705 -FKLMFDRSEVYGPMKNYLKKQVTPLFIHFRNNTNNWREIPENLMDQYSEVNAISTACSNGVPEC 768

  Fly   726 ISQAQGYFQSLATVPK------NIRATVYCVGLREGGEAEFQALYNKFKNETVATEETLLQNSFG 784
            .....|.|:.....|.      |:|:||||..:.:|||.|:...:.:|:|.|:..|...|:.:..
Human   769 EEMVSGLFKQWMENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFRNATLVNEADKLRAALA 833

  Fly   785 CVKTQSLIEKVFDLIIS-DEIRRQDKSSVLATLYTENNENVSPVFALVTQKYEELAEAMGGYS-A 847
            |.|...::.:.....:: |.||:||.:|.:.:: |.|......|:..|...:::|....||.| :
Human   834 CSKELWILNRYLSYTLNPDLIRKQDATSTIISI-TNNVIGQGLVWDFVQSNWKKLFNDYGGGSFS 897

  Fly   848 VATVISNIAARFTTNQQLTDLENFNKAN-GAKFGSSQATLTAAEATVKENLEW 899
            .:.:|..:..||:|..:|..||.|.|.| ...|||....|..|....|.|::|
Human   898 FSNLIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALEKTKANIKW 950

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31198NP_732654.1 Peptidase_M1 42..442 CDD:279741 161/425 (38%)
M1_APN_2 50..510 CDD:189008 178/490 (36%)
ERAP1_C 582..898 CDD:288671 97/332 (29%)
ANPEPNP_001141.2 Cytosolic Ser/Thr-rich junction 33..68 5/34 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 40..62 2/21 (10%)
Metalloprotease 69..967 296/916 (32%)
M1_APN-Q_like 84..545 CDD:341064 175/484 (36%)
Necessary and sufficient to mediate interaction with HCoV-229E. /evidence=ECO:0000269|PubMed:1350662, ECO:0000269|PubMed:8887485 288..295 1/6 (17%)
Substrate binding. /evidence=ECO:0000269|PubMed:22932899 352..356 3/3 (100%)
ERAP1_C 619..946 CDD:403137 96/330 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0308
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D110058at2759
OrthoFinder 1 1.000 - - FOG0000044
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11533
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X67
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.920

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