DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31198 and LVRN

DIOPT Version :9

Sequence 1:	NP_732654.1	Gene:	CG31198 / 318622	FlyBaseID:	FBgn0051198	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_776161.3	Gene:	LVRN / 206338	HGNCID:	26904	Length:	990	Species:	Homo sapiens

Alignment Length:	969	Identity:	253/969 - (26%)
Similarity:	423/969 - (43%)	Gaps:	136/969 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFAPRVAVLLVACVSLAS-------------AGTRQLSVDVQPP----------ATLATEL---- 38
            :.|..||.||:|...||:             .|.|.|..:..||          .:.|.||
Human    18 LLAGLVAALLLALAVLAALYGHCERVPPSELPGLRDLEAESSPPLRQKPTPTPKPSSARELAVTT 82

  Fly    39 -----------NEYRLAEHITPVNYNITLRPYLLETD---GNKRFTFDGEVWIEVISNQTTNDIY 89
                       ::.||...:.|::|::.|.|.|...:   |:..||  |.|.|.|.....|:.:.
Human    83 TPSNWRPPGPWDQLRLPPWLVPLHYDLELWPQLRPDELPAGSLPFT--GRVNITVRCTVATSRLL 145

  Fly    90 LHSKNLTYSVREYWQKPTTEVANPTVIQISATNT-TNYDTDIVKLTASTALTANTTYILHFVYTG 153
            |||........|.....:....|.||.::...:. ...||:.:.|..|..|...::|.|...::|
Human   146 LHSLFQDCERAEVRGPLSPGTGNATVGRVPVDDVWFALDTEYMVLELSEPLKPGSSYELQLSFSG 210

  Fly   154 LMEDDM-HGFYRSSYVDDNNVTKWLGSTQFQTHHARRAFPSFDEPQFKATFDVTLKRHRTFNSVS 217
            |:::|: .|.:.:.|.|.......|.| |.:...||..||.||||..||||::|:..|.::.::|
Human   211 LVKEDLREGLFLNVYTDQGERRALLAS-QLEPTFARYVFPCFDEPALKATFNITMIHHPSYVALS 274

  Fly   218 NTRLISSYPSTEEGIFSD-----VYKTTPKMSTYLLAFIISEF--VAR--KDDDFGVYARPEYYA 273
            |...:..  |.:|.:...     .:.|||.|.|||:||:|.::  |.|  :..:..::||.:..|
Human   275 NMPKLGQ--SEKEDVNGSKWTVTTFSTTPHMPTYLVAFVICDYDHVNRTERGKEIRIWARKDAIA 337

  Fly   274 QTQYPYNVGI-----QILEEMGQYLDKDYYSMGNDKMDMAAIPDFSAGAMENWGLLTYRERSLLV 333
            .....:.:.|     ..||:    |....||:  .|.|:.|:|.|...|||||||:.:.|..||:
Human   338 NGSADFALNITGPIFSFLED----LFNISYSL--PKTDIIALPSFDNHAMENWGLMIFDESGLLL 396

  Fly   334 DESATTLASRQSIAAVVAHEQAHMWFGDLVTCKWWSYTWLNEGFARYFQYFGTAMVEDKWELEKQ 398
            :........:..|:.||:||..|.|||:|||..||:..|||||||.||::........|....:.
Human   397 EPKDQLTEKKTLISYVVSHEIGHQWFGNLVTMNWWNNIWLNEGFASYFEFEVINYFNPKLPRNEI 461

  Fly   399 FVVDQVQSVMAMDSTNATNPLSDE-NTYTPAHLSRMFNSISYNKGATFIRMIKHTMGEQQFQKSL 462
            |..:.:.:::..|....|..::.: ..:..:.:..:|:..:|:|||:..||:...:.|..|..:|
Human   462 FFSNILHNILREDHALVTRAVAMKVENFKTSEIQELFDIFTYSKGASMARMLSCFLNEHLFVSAL 526

  Fly   463 QEYLKKYEYQSSLPEYLLGAWQANWPNSS---YNESSKDIFKSFTEQVGYPLI--NVTVG-NSQV 521
            :.|||.:.|.::..:.|...:|....:.|   ...:.|:|..|:|.|.|:|:|  ||:.| ..|.
Human   527 KSYLKTFSYSNAEQDDLWRHFQMAIDDQSTVILPATIKNIMDSWTHQSGFPVITLNVSTGVMKQE 591

  Fly   522 SF----TQKRFLLKESDGSDSSLKYTVPISYTTSETNN---FLNTTPKFILKPNVTTTVQFNSTI 579
            .|    .:.|.||..:|      .:.|||.:..:.|..   :|:.:.|...:..|:     :|..
Human   592 PFYLENIKNRTLLTSND------TWIVPILWIKNGTTQPLVWLDQSSKVFPEMQVS-----DSDH 645

  Fly   580 KWIVVNIQQTGYYRVTYSDDNWHAIHHALITANWGGIHENNRAQIVDDLFNLARAGYVTYNLTLD 644
            .|:::|:..||||||.|....|..::..| ..:...|...:|.|::||.|:|::..|:.....|:
Human   646 DWVILNLNMTGYYRVNYDKLGWKKLNQQL-EKDPKAIPVIHRLQLIDDAFSLSKNNYIEIETALE 709

  Fly   645 VIEYLQTETNYIPWTSAFNGFNYLTIRLGNDTADFNY------YIQTLTNKAYNQLGFNEASNDT 703
            :.:||..|...|.|.:..  .|.:|..|.::...::.      |:....|..:|........|..
Human   710 LTKYLAEEDEIIVWHTVL--VNLVTRDLVSEVNIYDIYSLLKRYLLKRLNLIWNIYSTIIRENVL 772

  Fly   704 AL-DIYLR----TKILSWACRYGSSDCISQAQGYFQSLATVPKN-----IRATVYCVGLREGGEA 758
            || |.||.    .|:...||..|..||:..::..|......|:|     |:..|.|.|:..|.:.
Human   773 ALQDDYLALISLEKLFVTACWLGLEDCLQLSKELFAKWVDHPENEIPYPIKDVVLCYGIALGSDK 837

  Fly   759 EFQALYNKFKNETVATEETLLQNSFGCVKTQSLIEKVFDLIISDEIRRQDKSSVLATLYTENNEN 823
            |:..|.|.:.|.|...|:..|..:..|.|...::.:..:..||            .:.:|.|..|
Human   838 EWDILLNTYTNTTNKEEKIQLAYAMSCSKDPWILNRYMEYAIS------------TSPFTSNETN 890

  Fly   824 VSPVFA-----------LVTQKYEELAEAMGGYSAVATVISNIAARFTTNQQLTDLENF 871
            :..|.|           .:...::.:::..|..|.: .:|..|....||:.|:.:|:.|
Human   891 IIEVVASSEVGRYVAKDFLVNNWQAVSKRYGTQSLI-NLIYTIGRTVTTDLQIVELQQF 948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31198	NP_732654.1	Peptidase_M1	42..442	CDD:279741	121/419 (29%)
		M1_APN_2	50..510	CDD:189008	139/482 (29%)
		ERAP1_C	582..898	CDD:288671	75/317 (24%)
LVRN	NP_776161.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..91		8/42 (19%)
		Peptidase_M1	97..506	CDD:279741	121/419 (29%)
		M1_APN_2	105..577	CDD:189008	139/482 (29%)
		Substrate binding. /evidence=ECO:0000250	379..383		2/3 (67%)
		ERAP1_C	648..951	CDD:288671	75/317 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920