DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31198 and anp-1

DIOPT Version :9

Sequence 1:	NP_732654.1	Gene:	CG31198 / 318622	FlyBaseID:	FBgn0051198	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_001041160.1	Gene:	anp-1 / 179763	WormBaseID:	WBGene00011587	Length:	988	Species:	Caenorhabditis elegans

Alignment Length:	924	Identity:	265/924 - (28%)
Similarity:	438/924 - (47%)	Gaps:	98/924 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 NEYRLAEHITPVNYNITLRPYL----LETDGNKRFTFDGEVWIEVISNQTTNDIYLHSKNLTYSV 99
            :|.||...::|::|.:|::.||    ...|.| ..||:|:|.||:...::...:.|:||:|.|:
Worm    82 SELRLPTSVSPISYQLTVKTYLPGYGYTADKN-NLTFEGQVLIELNITKSIKKVSLNSKDLNYT- 144

  Fly   100 REYWQKPTTEVANPTVIQISATNTTNYDTDIVKLTASTALTANTTYILHFVYTGLMEDDMHGFYR 164
            .|:.:|.:..|...::........:.::.....|..:...|.:.|  |...:...:..||.|.|:
Worm   145 EEFIKKSSILVNGKSIAFTLDDKQSTHEKIFFNLDETVEPTTSAT--LKVAFGAPLRTDMSGLYQ 207

  Fly   165 SSYVDDNNVTKWLGSTQFQTHHARRAFPSFDEPQFKATFDVTLKRHRTFNSVSNTRLISSYPSTE 229
            ::|.:....:|....||.:..:|||..|.||||.:|||:.||:.......:||| .:.......:
Worm   208 TTYTNSKGESKMAAVTQMEPVYARRMVPCFDEPAYKATWTVTVIHPNKTVAVSN-GIEDKVEDGQ 271

  Fly   230 EGIFSDVYKTTPKMSTYLLAFIISEF-----VARKDDDFGVYARPEYYAQTQYPYNVGIQILEEM 289
            .|.....:|.||:||:||||..||||     ..:....|.|::|||....|.|....|::.||
Worm   272 PGFIISTFKPTPRMSSYLLAIFISEFEYNEATTKSGVRFRVWSRPEEKNSTMYAVEAGVKCLE-- 334

  Fly   290 GQYLDKDYY--SMGNDKMDMAAIPDFSAGAMENWGLLTYRERSLLVDESATTLASRQSIAAVVAH 352
              |.:| ||  |....|.||.|:|||||||||||||:||||.:||.|....:.:.::.:|.|:||
Worm   335 --YYEK-YYNISFPLPKQDMVALPDFSAGAMENWGLITYRESALLYDPRIYSGSQKRRVAVVIAH 396

  Fly   353 EQAHMWFGDLVTCKWWSYTWLNEGFARYFQYFGTAMVED-KWELEKQFVVDQVQSVMAMDSTNAT 416
            |.||.|||:|||.|||:..|||||||...:|.||..:.| ...:.:.|.:|.:.|.:|.||..:|
Worm   397 ELAHQWFGNLVTLKWWNDLWLNEGFATLVEYLGTDEISDGNMRMREWFTMDALWSALAADSVAST 461

  Fly   417 NPLSDENTYTPAHLSRMFNSISYNKGATFIRMIKHTMGEQQFQKSLQEYLKKYEYQSSLPEYLLG 481
            :||:.:.......|. .|:|::|:||...:.|::.|:||:.|...:..||.::::.::....||.
Worm   462 HPLTFKIDKAMEVLD-SFDSVTYDKGGAVLAMVRKTIGEENFNTGINHYLTRHQFDNADAGNLLT 525

  Fly   482 AWQANWPNSSYNESS-----KDIFKSFTEQVGYPLINVT-VGNSQVSFTQKRFLL----KESDGS 536
            |.....|:|......     .:....:|:|:||||:|.: :.|:.:...|.||.|    ||.:..
Worm   526 ALGEKIPDSVMGPKGVKLNISEFMDPWTKQLGYPLLNASRINNTHIIVEQSRFKLLATGKEEEKY 590

  Fly   537 DS---SLKYTVPISYT---TSETN-NFLNTTPKFILKPNVTTTVQFNSTIKWIVVNIQQTGYYRV 594
            .:   ..|:.||:.|.   :||.. .::......|:|.:           |.:::|.:..|:||.
Worm   591 SNPVWGFKWDVPVWYQVVGSSELEMKWMKRNEPLIIKSD-----------KNVIINAESNGFYRA 644

  Fly   595 TYSDDNWHAIHHALITANWGGIHENNRAQIVDDLFNLARAGYVTYNLTLDVIEYLQTETNYIPWT 659
            .||...|..|.. ::..|........|.:::||.|.|||||.::|::.|::|.||:.|..|:||:
Worm   645 GYSSGLWKEISE-MLKENHEQFSPQTRVRLIDDSFALARAGLLSYSIPLNLITYLKNEKEYLPWS 708

  Fly   660 SAFNGFNYLTIRLGNDTADFNYYIQTLTNKAYNQLGFN---EASNDTALDIYLRTK--------- 712
            .|......|....|::..      :.:.||....|..|   ..|.|.....||..|
Worm   709 GAIAKIRELIDMYGSNPE------KDIVNKFMIALAENAPARRSIDFVSKNYLDEKKFYEVGAAQ 767

  Fly   713 -ILSWACRYGSSDCIS--------------QAQGYFQSLATVPKNIRATVYCVGLREGGEAEFQA 762
             |:..:|.:|.|.|.:              .|.......:.:|...||..||..:|.|....|:.
Worm   768 QIILNSCGFGDSVCQADMVKMFTEEVLAKCDATRILSECSQIPAPFRAESYCEAVRNGNSDTFEK 832

  Fly   763 LYNKFKNETVATEETLLQNSFGCVKTQSLIEKVFDLIISDE---IRRQDKSSVLATLYTENNENV 824
            :::.:|.|....|:..|..:..|.|....::|:....:..|   .|.||.:::.|.: :.|:...
Worm   833 VFHWYKTERNQVEKLNLMTALTCSKDILTLKKLLLDAMKPEGSSFRLQDCAALFAKI-SSNDATT 896

  Fly   825 SPVFALVTQKYEELAEAMG-GYSAVATVISNIAARFTTNQQLTDLENFNK--ANGAKFG------ 880
            ..:...:..::|::.:.:. .:|..:.|:|:|.....|...|..|..|.|  ...::||
Worm   897 DAMLNFLIDRWEDMQKRLATDHSGFSRVLSSIVNTLKTRGGLDQLRKFRKKAPKASEFGLDKMEE 961

  Fly   881 SSQATLTAAEATVK 894
            |::.|:|..|..:|
Worm   962 SAEVTVTWRETNLK 975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31198	NP_732654.1	Peptidase_M1	42..442	CDD:279741	144/411 (35%)
		M1_APN_2	50..510	CDD:189008	158/476 (33%)
		ERAP1_C	582..898	CDD:288671	83/352 (24%)
anp-1	NP_001041160.1	Peptidase_M1	85..486	CDD:279741	144/411 (35%)
		M1_APN_2	93..559	CDD:189008	158/476 (33%)
		ERAP1_C	632..964	CDD:288671	79/339 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.020