DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31198 and T16G12.1

DIOPT Version :9

Sequence 1:	NP_732654.1	Gene:	CG31198 / 318622	FlyBaseID:	FBgn0051198	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_499230.2	Gene:	T16G12.1 / 176416	WormBaseID:	WBGene00011803	Length:	1890	Species:	Caenorhabditis elegans

Alignment Length:	924	Identity:	240/924 - (25%)
Similarity:	399/924 - (43%)	Gaps:	187/924 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 RLAEHITPVNYNITLRPYL----LETDGNKRFTFDGEVWIEVISNQTTNDIYLHSKNLTYSVREY 102
            ||..::..::|::..:||.    ::....|.|||||...|:|.:...::...|::.|  :.::.|
Worm    80 RLPPNLYAIDYSLWFQPYFPSPGVQYAPEKNFTFDGRASIQVEALVASDRFILNAYN--FKIQSY 142

  Fly   103 WQKPTTEVANPTVIQISATNTTNYDTDIVKLTASTALTANTTYILHFVYTGLMEDDMH-GFYRSS 166
               ...:: :.||:.|::.:..:....:..:|.:..:.|...|.:.|||||::..... |.|.:|
Worm   143 ---KVVDI-DGTVVPINSISQDDTTQQLSLITNANGVVAGQIYNIEFVYTGIINPYTDGGVYYTS 203

  Fly   167 YVDDNNVTKWLGSTQFQTHHARRAFPSFDEPQFKATFDVTLKRHRTFNSVSNTRLISSYPSTEEG 231
            |.|....|.::.:|..:...||:.|||.|||.:||.|.:|::...:..::||  ::.:.|:..:.
Worm   204 YNDPQGNTHYMIATHMEPFSARKVFPSLDEPSYKAKFTITVQYPASQVALSN--MMETEPTKIDN 266

  Fly   232 IFSDV-YKTTPKMSTYLLAFII-----SEFVARKDDDFGVYARP--EYYAQTQYPYNVGIQILEE 288
            |:|.: :..|||||:||:||.:     |::|.:.:.....:..|  |.|.|.. ..|.| :.|.:
Worm   267 IWSTITFPQTPKMSSYLIAFAVGPYVNSQYVNKHNTLTRAWGWPGTEQYLQFA-AQNAG-ECLYQ 329

  Fly   289 MGQYLDKDYYSMGNDKMDMAAIPDFSAGAMENWGLLTYRERSLLVDESATTLASRQSIAAVVAHE 353
            :|:|..   ......|.|...:|:|.|||||||||:.|:.:.:..:.:..|..:.::.|.|:.||
Worm   330 LGEYTG---IKFPLSKADQLGMPEFLAGAMENWGLIIYKYQYIAYNPTTMTTRNMEAAAKVMCHE 391

  Fly   354 QAHMWFGDLVTCKWWSYTWLNEGFARYFQYFGTAMV--EDKWELEKQFVVDQVQSVMAMDSTNAT 416
            .||.|||||||..||...:||||||.||..|....|  :....|:...|:|::|..:..|.....
Worm   392 LAHQWFGDLVTTAWWDDLFLNEGFADYFMTFIQKSVYPQQATYLDTLQVLDELQVGLTADVRYDA 456

  Fly   417 NPLSDENTYT--PAHLSRMFNSISYNKGATFIRMIKHTMGEQQFQKSLQEYLKKYEYQSS----L 475
            :||    .|.  ||     |:.|:|||||:.:||:...:|...|::.::.||:|.:|.::    |
Worm   457 HPL----VYPDGPA-----FDDITYNKGASMLRMLSDVLGADVFKQGIRAYLQKMQYSNANDFDL 512

  Fly   476 PEYLLGAWQAN----WPNSSYNESSKDIFKSFTEQVGYPLI----NVTVGNSQVSFTQKRFLLKE 532
            ...|....::|    |.....|.:  |..:.:..|..:|||    |..:|.|  :|:|:.| |..
Worm   513 FSTLTDTAKSNNILDWCGLPLNVT--DFMQPYIHQTNHPLIRYNNNQKIGGS--TFSQEPF-LDI 572

  Fly   533 SDGSDSSLKYTVPISYTTSE-----------------TNNFLNTTPKFILKPNVTTTVQFNSTIK 580
            ||.:.:...||..|..|::.                 .|...|...:.|.:||       ...::
Worm   573 SDLTATPWNYTWSIPLTSANLRHADPYKQWLPRQQGCANMNENIQEERIKEPN-------KRAVQ 630

  Fly   581 WIVVNIQQTGYYRVTYSDDNWHAIHHALITANWGGIHENNRAQIVDDLFNLARAGYVT------- 638
            |.:.:|....|.|:.|.|..:..|   |.......|::|.:..::.|.:|     |:.
Worm   631 WELTSITSATYGRIIYDDIGFDRI---LKLIKQDDINDNLKLTLLADEYN-----YMLREKKANR 687

  Fly   639 ---YNLTLD---VIEYLQTETNYIPWTSAFNGFNYL---TIRLGNDTADFNY---YIQTLTNKAY 691
               ||..||   ||...|:.||| |....|.....:   ..:|..|..|..:   ..:.....:|
Worm   688 PFGYNRFLDLAKVIFNTQSFTNY-PSYGVFAQAQPVLEQIAQLYRDGIDAEFVPRLYKLFFQNSY 751

  Fly   692 NQLGFNEAS---NDTALDIYLRTKILSWACRYGSSD---------------CISQAQG--YFQSL 736
            |||.:.:.|   .||..:::     |.:|.||...|               ||:...|  :....
Worm   752 NQLKWQDTSIWDTDTFSEVF-----LPFAVRYDIGDVQNRTLNMFANVKSACINSLNGTAWCNPY 811

  Fly   737 ATVPKNIRATVYCVGLREGGEAE---------FQAL--YNK--FKNETVATEETLLQNSFGCVKT 788
            :|   |:|..:||      |.|:         ||.|  |||  ..|.....|...|.....|.::
Worm   812 ST---NLRKAIYC------GAAKYAPATSDYFFQMLHSYNKEVITNPYFYQEYMALLEGMSCTQS 867

  Fly   789 QSLIEKVFDLIISDEIRRQDKSSVLATLYTENNENVSPVFALVTQKYEELAEAMGGYSAVATVIS 853
            .:.::                  ||..|:|.:..|.|.:|..:  ||.         .|.:.|:.
Worm   868 PATLK------------------VLIRLFTTSTLNPSTIFGFL--KYN---------PAASDVLY 903

  Fly   854 NIAARFTTNQQLTD 867
            |.   |..|.||.:
Worm   904 NY---FMANPQLVN 914

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31198	NP_732654.1	Peptidase_M1	42..442	CDD:279741	125/416 (30%)
		M1_APN_2	50..510	CDD:189008	141/484 (29%)
		ERAP1_C	582..898	CDD:288671	75/338 (22%)
T16G12.1	NP_499230.2	M1_APN_2	88..549	CDD:189008	141/484 (29%)
		ERAP1_C	640..931	CDD:314669	74/330 (22%)
		Peptidase_M1	999..1402	CDD:279741
		ERAP1_C	1542..1839	CDD:314669
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920