DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31198 and Lnpep

DIOPT Version :9

Sequence 1:	NP_732654.1	Gene:	CG31198 / 318622	FlyBaseID:	FBgn0051198	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_001106874.1	Gene:	Lnpep / 171105	RGDID:	621752	Length:	1025	Species:	Rattus norvegicus

Alignment Length:	969	Identity:	290/969 - (29%)
Similarity:	461/969 - (47%)	Gaps:	133/969 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VAVLLVACVSLASAG---TRQLSVDVQPPATLATEL--NEYRLAEHITPVNYNITLRPYLLETDG 65
            |..||..| :....|   |.|.:..:||.||.....  .:.||...|.|..|.::|.|.|..
  Rat   127 VIYLLPRC-TFTKEGCHKTNQSAELIQPIATNGKVFPWAQIRLPTAIIPQRYELSLHPNLTS--- 187

  Fly    66 NKRFTFDGEVWIEVISNQTTNDIYLHSKNLTYSVREYWQKPTTEVANPTVIQISATNTTNYDTDI 130
               .||.|.|.|.:.:.|.|.||.|||.....|               :|..:||.::.....:|
  Rat   188 ---MTFRGSVTISLQALQDTRDIILHSTGHNIS---------------SVTFMSAVSSQEKQVEI 234

  Fly   131 --------VKLTASTALTANTTYILHFVYTGLMEDDMHGFYRSSYVDDNNVTKWLGSTQFQTHHA 187
                    :.:.|..:|.....|.|...|:..:.:..:|||..:|.|.:|..|...:|||:...|
  Rat   235 LEYPYHEQIAVVAPESLLTGHNYTLKIEYSANISNSYYGFYGITYTDKSNEKKNFAATQFEPLAA 299

  Fly   188 RRAFPSFDEPQFKATFDVTLKRHRTFNSVSNTRLISSYPSTEEGIFSDVYKTTPKMSTYLLAFII 252
            |.|||.||||.|||||.:.:.|.....::||....||.| ||||:..|.:..:.||||||:|||:
  Rat   300 RSAFPCFDEPAFKATFIIKITRDEHHTALSNMPKKSSVP-TEEGLIQDEFSESVKMSTYLVAFIV 363

  Fly   253 SEFVARKDDDFG----VYARPEYYAQTQYPYNVGIQILEEMGQYLDKDYYSMGNDKMDMAAIPDF 313
            .|......|..|    |||.||...|..:..:..:::||....|.:..|   ...|:|:.|||||
  Rat   364 GEMRNLSQDVNGTLVSVYAVPEKIDQVYHALDTTVKLLEFYQNYFEIQY---PLKKLDLVAIPDF 425

  Fly   314 SAGAMENWGLLTYRERSLLVDESATTLASRQSIAAVVAHEQAHMWFGDLVTCKWWSYTWLNEGFA 378
            .|||||||||||:||.:||.|.:.:::|.|:.:..::|||.||.|||:|||.:||:..|||||||
  Rat   426 EAGAMENWGLLTFREETLLYDNATSSVADRKLVTKIIAHELAHQWFGNLVTMQWWNDLWLNEGFA 490

  Fly   379 RYFQYFGTAMVEDKWELEKQFVVDQVQSVMAMDSTNATNPLSDENTYTPAHLSRMFNSISYNKGA 443
            .:.:||....:..:....:.| :|.....|..||.|:::|:| .:..:...:..||:|:||.|||
  Rat   491 TFMEYFSVEKIFKELNSYEDF-LDARFKTMRKDSLNSSHPIS-SSVQSSEQIEEMFDSLSYFKGA 553

  Fly   444 TFIRMIKHTMGEQQFQKSLQEYLKKYEYQSSLPEYLLGAWQANWPNSSYNESS------KDIFKS 502
            :.:.|:|..:.|..||.::..||..:.|.:...:.|       |  .|:||.:      |.:.|:
  Rat   554 SLLLMLKSYLSEDVFQHAIILYLHNHSYAAIQSDDL-------W--DSFNEVTGKTLDVKKMMKT 609

  Fly   503 FTEQVGYPLINVTVGNSQVSFTQKRF---LLKESDGSDSSLKYTVPISYTTSETN-------NFL 557
            :|.|.|:||:.|....:::...|:||   :..|...||:|..:.:||||.|...|       :.|
  Rat   610 WTLQKGFPLVTVQRKGTELLLQQERFFPSMQPEIQDSDTSHLWHIPISYVTDGRNYSEYRSVSLL 674

  Fly   558 NTTPKFILKPNVTTTVQFNSTIKWIVVNIQQTGYYRVTYSDDNWHAIHHALITANWGGIHENNRA 622
            :.....|   |:|..||      |:.||...||||.|.|:.|.|.|:.:.| ..|...:.:.:||
  Rat   675 DKKSDVI---NLTEQVQ------WVKVNTNMTGYYIVHYAHDGWAALINQL-KRNPYVLSDKDRA 729

  Fly   623 QIVDDLFNLARAGYVTYNLTLDVIEYLQTETNYIPWTSA-------FNGFNYLTIRLGNDTADFN 680
            .:::::|.||..|.|...:..|:|:||:.||:..|.|.|       :|    |..:||:  .|.:
  Rat   730 NLINNIFELAGLGKVPLQMAFDLIDYLRNETHTAPITEALFQTDLIYN----LLEKLGH--MDLS 788

  Fly   681 YYIQTLTNKAYNQLGFNEASNDTALD------IYLRTKILSWACRYGSSDCISQA----QGYFQS 735
            ..:.|..:|...    |:....|..|      ..||:.:|.:||.:...:|.:.|    .|:..|
  Rat   789 SRLVTRVHKLLQ----NQIQQQTWTDEGTPSMRELRSALLEFACAHSLENCTTMATKLFDGWMAS 849

  Fly   736 LAT--VPKNIRATVYCVGLR-EGGEAEFQALYNKFKNETVATEETLLQ---NSFGCVKTQSLIEK 794
            ..|  :|.::..||:.||.| |.|.....::|:...:|  |.::.:|:   :|....|...|::.
  Rat   850 NGTQSLPTDVMTTVFKVGARTEKGWLFLFSMYSSMGSE--AEKDKILEALASSADAHKLYWLMKS 912

  Fly   795 VFDLIISDEIRRQDKSSVLATLYTENNENVSPVFALVTQKYEELAEA--MGGYSAVATVISNIAA 857
            ..|   .|.||.|..|.::.|:..:...::. .:..|.:.:.:|...  :|.|: :.::::....
  Rat   913 SLD---GDIIRTQKLSLIIRTVGRQFPGHLL-AWDFVKENWNKLVHKFHLGSYT-IQSIVAGSTH 972

  Fly   858 RFTTNQQLTDLENFNKANGAKFGSSQATL-----TAAEATVKENLEWATAKLGVFRSYL 911
            .|:|...|::::.|.:      ..|:|||     ..|...::.|::|....|.....:|
  Rat   973 LFSTKTHLSEVQEFFE------NQSEATLQLRCVQEAFEVIELNIQWMARNLKTLTLWL 1025

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31198	NP_732654.1	Peptidase_M1	42..442	CDD:279741	147/411 (36%)
		M1_APN_2	50..510	CDD:189008	164/477 (34%)
		ERAP1_C	582..898	CDD:288671	85/345 (25%)
Lnpep	NP_001106874.1	Dileucine internalization motif. /evidence=ECO:0000255	53..54
		Dileucine internalization motif. /evidence=ECO:0000255	76..77
		Tankyrase binding. /evidence=ECO:0000250	96..101
		Peptidase_M1	167..552	CDD:279741	147/411 (36%)
		M1_APN_2	176..617	CDD:189008	164/476 (34%)
		Substrate binding. /evidence=ECO:0000250	428..432		3/3 (100%)
		ERAP1_C	690..1005	CDD:288671	84/338 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920