Protein Alignment CG31198 and Lta4h

DIOPT Version :9

• Sequence 1: NP_732654.1
• Gene: CG31198 / 318622
• FlyBaseID: FBgn0051198
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: NP_032543.2
• Gene: Lta4h / 16993
• MGIID: 96836
• Length: 611
• Species: Mus musculus
• Alignment Length: 554
• Identity: 116/554 - (20%)
• Similarity: 212/554 - (38%)
• Gaps: 145/554 - (26%)

  Fly    68 RFTFDGEVWIEVIS-NQTTNDIYLHSKNLTYSVREYWQKPTTEVANPTVIQISATNTTNYDTDIV 131
            |.|..|...:.|.| .:....:.|.:|:||..         ..|.|...::.:...:..|....:
Mouse    32 RRTLTGTAALTVQSQEENLRSLTLDTKDLTIE---------KVVINGQEVKYTLGESQGYKGSPM 87

  Fly   132 KLTASTALTANTTYILHFVYTGLMEDDMHGFYRSSYVDDNNVTKWLGS------------TQFQT 184
            :::...||:.|...::..           .|..|   ..::..:||..            :|.|.
Mouse    88 EISLPIALSKNQEIVIEI-----------SFETS---PKSSALQWLTPEQTSGKQHPYLFSQCQA 138

  Fly   185 HHARRAFPSFDEPQFKATF--DVTLKRHRTFNSVSNTRLISSYPSTEEGIFSD-------VYKTT 240
            .|.|...|..|.|..|.|:  :|::.:          .|::...:..:|...|       :|:..
Mouse   139 IHCRAILPCQDTPSVKLTYTAEVSVPK----------ELVALMSAIRDGEAPDPEDPSRKIYRFN 193

  Fly   241 PK--MSTYLLAFIISEFVARKDDDFG----VYARPEYYAQTQYPYNVG---IQILEEM-GQYLDK 295
            .:  :..||:|.::....:|:   .|    |::..|...::...::..   ::|.|:: |.|:..
Mouse   194 QRVPIPCYLIALVVGALESRQ---IGPRTLVWSEKEQVEKSANEFSETESMLKIAEDLGGPYVWG 255

  Fly   296 DYYSMGNDKMDMAAI-PDFSAGAMENWGLLTYRERSLLVDESATTLASRQSIAAVVAHEQAHMWF 359
            .|        |:..: |.|..|.||| ..||:        .:.|.||..:|::.|:|||.:|.|.
Mouse   256 QY--------DLLVLPPSFPYGGMEN-PCLTF--------VTPTLLAGDKSLSNVIAHEISHSWT 303

  Fly   360 GDLVTCKWWSYTWLNEG-------------FARYFQYFGTAMVEDKW-ELE---KQFVVDQVQSV 407
            |:|||.|.|.:.|||||             |...|::|...   ..| ||:   |.|......:.
Mouse   304 GNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFHAL---GGWGELQNTIKTFGESHPFTK 365

  Fly   408 MAMDSTNATNPLSDENTYTPAHLSRMFNSISYNKGATFIRMIKHTM-GEQQFQKSLQEYLKKYEY 471
            :.:|..:....::             ::||.|.||...:..::..: |.:.|...|:.|:||:.|
Mouse   366 LVVDLKDVDPDVA-------------YSSIPYEKGFALLFYLEQLLGGPEVFLGFLKAYVKKFSY 417

  Fly   472 QSSLPEYLLGAWQANWPNSSYNESSKDIFKSFTEQVGY-------------PLINVTVGNSQVSF 523
            ||...:        :|.:..|:.....:  ....||.:             |..:||:.|:.::.
Mouse   418 QSVTTD--------DWKSFLYSHFKDKV--DLLNQVDWNTWLYAPGLPPVKPNYDVTLTNACIAL 472

  Fly   524 TQKRFLLKESDGSDSSLKYTVPISYTTSETNNFL 557
            :|:....||.|.|..|:.....:|  :.:.|.||
Mouse   473 SQRWVTAKEEDLSSFSIADLKDLS--SHQLNEFL 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31198	NP_732654.1	Peptidase_M1	42..442	CDD:279741	87/423 (21%)
		M1_APN_2	50..510	CDD:189008	102/505 (20%)
		ERAP1_C	582..898	CDD:288671
Lta4h	NP_032543.2	leuko_A4_hydro	6..608	CDD:274120	116/554 (21%)
		M1_LTA4H	6..450	CDD:189006	102/496 (21%)
		Substrate binding. /evidence=ECO:0000250|UniProtKB:P09960	135..137		1/1 (100%)
		Substrate binding. /evidence=ECO:0000250|UniProtKB:P09960	267..272		1/4 (25%)
		Leuk-A4-hydro_C	468..607	CDD:286244	10/39 (26%)
		Substrate binding. /evidence=ECO:0000250|UniProtKB:P09960	564..566

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810