DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31198 and Anpep

DIOPT Version :9

Sequence 1:	NP_732654.1	Gene:	CG31198 / 318622	FlyBaseID:	FBgn0051198	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_032512.2	Gene:	Anpep / 16790	MGIID:	5000466	Length:	966	Species:	Mus musculus

Alignment Length:	957	Identity:	307/957 - (32%)
Similarity:	477/957 - (49%)	Gaps:	108/957 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ASAGTRQLSVDVQPPATLATELNEYRLAEHITPVNYNITLRPYLLETDGNK-RFTFDGEVWIEVI 80
            |:..|...:||...|      .|:|||.:.:.|.:|.:.|||||  |..|: .:.|.|...:...
Mouse    56 ATTATTTPAVDESKP------WNQYRLPKTLIPDSYRVILRPYL--TPNNQGLYIFQGNSTVRFT 112

  Fly    81 SNQTTNDIYLHSKNLTYSVREYWQKPTTEVANPTVI--QISATNTTNYD-TDIVKLT------AS 136
            .||||:.|.:|||.|.|:::          .|..|:  .:..|...|.| |::|:.|      ..
Mouse   113 CNQTTDVIIIHSKKLNYTLK----------GNHRVVLRTLDGTPAPNIDKTELVERTEYLVVHLQ 167

  Fly   137 TALTANTTYILHFVYTGLMEDDMHGFYRSSYVDDNNVTKWLGSTQFQTHHARRAFPSFDEPQFKA 201
            .:|.....|.:...:.|.:.||:.|||||.|: :.:|.|.:.:||.|...||::||.||||..||
Mouse   168 GSLVEGRQYEMDSQFQGELADDLAGFYRSEYM-EGDVKKVVATTQMQAADARKSFPCFDEPAMKA 231

  Fly   202 TFDVTLKRHRTFNSVSNTRLISSYPSTEE-GIFSDVYKTTPKMSTYLLAFIISEF-----VARKD 260
            .|::||.......::||.....|.|..|: ......:.:||||||||||:|:|||     |:...
Mouse   232 MFNITLIYPNNLIALSNMLPKESKPYPEDPSCTMTEFHSTPKMSTYLLAYIVSEFKNISSVSANG 296

  Fly   261 DDFGVYARPEYY--AQTQYPYNVGIQILEEMGQYLDKDYYSMGNDKMDMAAIPDFSAGAMENWGL 323
            ...|::|||...  .|..|..||...||....|:.:..|   ...|.|..|:|||:|||||||||
Mouse   297 VQIGIWARPSAIDEGQGDYALNVTGPILNFFAQHYNTSY---PLPKSDQIALPDFNAGAMENWGL 358

  Fly   324 LTYRERSLLVDESATTLASRQSIAAVVAHEQAHMWFGDLVTCKWWSYTWLNEGFARYFQYFGTAM 388
            :||||.||:.|..::::::::.:..|:|||.||.|||:|||..||:..|||||||.|.:|.|...
Mouse   359 VTYRESSLVFDSQSSSISNKERVVTVIAHELAHQWFGNLVTVAWWNDLWLNEGFASYVEYLGADY 423

  Fly   389 VEDKWELEKQFVVDQVQSVMAMDSTNATNPLSD--ENTYTPAHLSRMFNSISYNKGATFIRMIKH 451
            .|..|.|:...|::.|..|||:|:..:::|||.  :...||..:..:|:||:|:|||:.|||:..
Mouse   424 AEPTWNLKDLMVLNDVYRVMAVDALASSHPLSSPADEIKTPDQIMELFDSITYSKGASVIRMLSS 488

  Fly   452 TMGEQQFQKSLQEYLKKYEYQSSLPEYLLGAWQANWPNSSYNESS--------KDIFKSFTEQVG 508
            .:.|..|:|.|..||..|:|.:::   .|..|:  ....:.|:.:        :.|...:..|:|
Mouse   489 FLTEDLFKKGLSSYLHTYQYSNTV---YLDLWE--HLQKAVNQQTAVQPPATVRTIMDRWILQMG 548

  Fly   509 YPLINVTVGNSQVSFTQKRFLLKESDG----SDSSLKYTVPISYTTS--ETNNFLNTTPKFILKP 567
            :|:|.|.....::|  ||.|||.....    |:.:..:..||.:..|  |.:.:|:      ::.
Mouse   549 FPVITVNTNTGEIS--QKHFLLDSKSNVTRPSEFNYIWIAPIPFLKSGQEDHYWLD------VEK 605

  Fly   568 NVTTTVQFNSTIKWIVVNIQQTGYYRVTYSDDNWHAIHHALITANWGGIHENNRAQIVDDLFNLA 632
            |.:...|.:|. :||::||..||||.|.|.::||..:.:.|.| :...|...|||||:.|.||||
Mouse   606 NQSAKFQTSSN-EWILLNINVTGYYLVNYDENNWKKLQNQLQT-DLSVIPVINRAQIIHDSFNLA 668

  Fly   633 RAGYVTYNLTLDVIEYLQTETNYIPWTSAFNGFNYLTIR-------------LGNDTADFNYYIQ 684
            .|..:...|.||...:|..|..|:||.:|.:..||.|:.             |........:|.|
Mouse   669 SAKMIPITLALDNTLFLVKEAEYMPWQAALSSLNYFTLMFDRSEVYGPMKRYLKKQVTPLFFYFQ 733

  Fly   685 TLTNKAYNQLGFNEASNDTALDIYLRTKILSWACRYGSSDCIS-QAQGYFQSLA-----TVPKNI 743
            ..||...|:       ..|.::.|.....:|.||..|..:|.. ..:.|.|.:.     |:..|:
Mouse   734 NRTNNWVNR-------PPTLMEQYNEINAISTACSSGLKECRDLVVELYSQWMKNPNNNTIHPNL 791

  Fly   744 RATVYCVGLREGGEAEFQALYNKFKNETVATEETLLQNSFGCVKTQSLIEKVFDLIIS-DEIRRQ 807
            |:||||..:..|||.|:...:.:|:|.|:..|...|:::..|.|...::.:.....:: |.||:|
Mouse   792 RSTVYCNAIAFGGEEEWNFAWEQFRNATLVNEADKLRSALACSKDVWILNRYLSYTLNPDYIRKQ 856

  Fly   808 DKSSVLATLYTENNENVSP---VFALVTQKYEELAEAMGGYS-AVATVISNIAARFTTNQQLTDL 868
            |.:|.:.::.:    ||:.   |:..|...:::|.|..||.| :.|.:|..:..||::..:|..|
Mouse   857 DTTSTIISIAS----NVAGHPLVWDFVRSNWKKLFENYGGGSFSFANLIQGVTRRFSSEFELQQL 917

  Fly   869 ENFNKANGAK-FGSSQATLTAAEATVKENLEWATA-KLGVFRSYLAN 913
            |.|...|.|. ||:....|..|....:.|::|... |..||:.:..|
Mouse   918 EQFKADNSATGFGTGTRALEQALEKTRANIDWVKENKDAVFKWFTEN 964

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31198	NP_732654.1	Peptidase_M1	42..442	CDD:279741	156/419 (37%)
		M1_APN_2	50..510	CDD:189008	173/487 (36%)
		ERAP1_C	582..898	CDD:288671	100/340 (29%)
Anpep	NP_032512.2	Cytosolic Ser/Thr-rich junction	33..68		4/11 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..64		2/7 (29%)
		Metalloprotease	69..966		303/944 (32%)
		M1_APN-Q_like	84..545	CDD:341064	171/481 (36%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P15144	351..355		3/3 (100%)
		ERAP1_C	618..945	CDD:403137	100/338 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920