DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31198 and Rnpepl1

DIOPT Version :9

Sequence 1:	NP_732654.1	Gene:	CG31198 / 318622	FlyBaseID:	FBgn0051198	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_852070.3	Gene:	Rnpepl1 / 108657	MGIID:	1914170	Length:	720	Species:	Mus musculus

Alignment Length:	453	Identity:	110/453 - (24%)
Similarity:	189/453 - (41%)	Gaps:	88/453 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 RRAFPSFDEPQFKATFDVTLKRHRTFNSVSNTRLISSYPST---EEGIFSDVYKTTPKMSTYLLA 249
            |..||.||.|..|.|:...:|.     .:....|:|:..|.   |||::.  :.....:..||:|
Mouse   198 RSFFPCFDTPAVKCTYSAVVKA-----PLGVQVLMSATQSVYVEEEGLYH--FHMEHPVPAYLVA 255

  Fly   250 FIISEFVARKDDDFG----VYARPEYYAQTQYPYNVGIQILEEMGQYL---DKDY--YSMGNDKM 305
            .:..:.   |..|.|    |:|.|..........:..::      |:|   ::.|  |..|  :.
Mouse   256 LVAGDL---KPADIGPRSRVWAEPCLLPTATSKLSGAVE------QWLSAAERLYGPYMWG--RY 309

  Fly   306 DMAAI-PDFSAGAMENWGLLTYRERSLLVDESATTLASRQSIAAVVAHEQAHMWFGDLVTCKWWS 369
            |:..: |.|...|||| ..||:...|:        |.|.:.:...|.||.||.|||:.||...|.
Mouse   310 DIVFLPPSFPIVAMEN-PCLTFIISSI--------LESDEFLVIDVIHEVAHSWFGNAVTNATWE 365

  Fly   370 YTWLNEGFARYFQ------YFGTAMVEDKWELEKQFVVDQVQSVMAM---DSTNATNPLSDENTY 425
            ..||:||.|.|.|      .:|.|..    .||..|.:|.:...|.:   ||..:...:..|...
Mouse   366 EMWLSEGLATYAQRRITTETYGAAFT----CLETAFRLDALHRQMRLLGEDSPVSKLQVKLEPGV 426

  Fly   426 TPAHLSRMFNSISYNKGATFIRMIKHTM-GEQQFQKSLQEYLKKYEYQSSLPEYLLGAWQANWPN 489
            .|:||..:|   :|.||..|:..:.... |.|:|...|:.|::||::.|.:.:.||.::.:.:|
Mouse   427 NPSHLMNLF---TYEKGYCFVYYLSQLCGGPQRFDDFLRAYVEKYKFTSVVAQDLLDSFLSFFP- 487

  Fly   490 SSYNESSKDI-----FKSFTEQVGYPLI--NVTVGNSQVSFTQKRFL------LKESDGSDSSLK 541
             ...|.|.|.     |:.:....|.||.  :::.|:|.....:..|.      |:::..|.|::.
Mouse   488 -ELKEQSVDCRAGLEFERWLNATGPPLAEPDLSQGSSLTRPVEALFQLWTAEPLEQAAASASAID 551

  Fly   542 YTVPISYTTSETNNFL------NTTPKFILK------PNVTTTVQFNSTIKWIVVNIQQTGYY 592
            .:   .:.|.:|..||      :..|:.::.      .::..::.....|:|:.: :.:..||
Mouse   552 IS---KWRTFQTALFLDRLLDGSPLPQEVVMSLSKCYSSLLDSMNAEIRIRWLQI-VVRNDYY 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31198	NP_732654.1	Peptidase_M1	42..442	CDD:279741	74/275 (27%)
		M1_APN_2	50..510	CDD:189008	93/349 (27%)
		ERAP1_C	582..898	CDD:288671	2/11 (18%)
Rnpepl1	NP_852070.3	M1_LTA4H	29..507	CDD:189006	92/344 (27%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P15144	321..325		2/3 (67%)
		Leuk-A4-hydro_C	524..668	CDD:312599	13/91 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..708
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810